About Journal

The International Journal of Radiation Medicine and Nuclear Medicine is one of the national medical journals which is administered by National Health Commission of the People’s Republic of China and published by Chinese Medical Association and Institute of Radiation Medicine.
Founded in 1977, the journal was formerly known as Foreign Medicine: Radiation Medicine and Nuclear Medicine. In 2006, it was renamed The International Journal of Radiation Medicine and Nuclear Medicine.
The journal takes the scientific research personnel and clinicians engaging in radiation medicine and nuclear medicine or the related areas as the target readers, the original article, review and reports in the international academic conference as the main forms. It particularly reports the new trends, recent developments, up-to-date technologies, and the newly-acquired experience in overseas and mainland in the fields of radiation medicine and nuclear medicine with the domestic situation, emphasizes article’s scientificalness and timeliness. This print specialized in experimental nuclear medicine, clinical nuclear medicine, radiobiology, clinical radiation medicine, radiation does, damage and radiation protection, radioactive labeling of drugs, molecular biology technology, radiation and security and related standards and regulations.

Periodical Information
Superintended by: National Health Commission of the People's Republic of China
Sponsored by:
Chinese Medical Association
Institute of Radiation Medicine, Chinese Academy of Medical Sciences
Editor: Editorial Board of International Journal of Radiation Medicine and Nuclear Medicine
Publisher: Editorial Office of International Journal of Radiation Medicine and Nuclear Medicine
Editor-in-Chief: Fan Saijun
Managing Director: Song Naling
Address: 238 Baidi Road, Nankai, Tianjin
Tel: 86-22-58089989
86-22-85682389
Fax: 86-22-58089989
CSSN: ISSN 1673-4114
CN 12-1381/R
Issue Code: 6-102
Licenses for Advertising Operation: 津工商广字1201044000168
Order: Post Offices of all over the country
Email: gjfh2006@irm-cams.ac.cn
Price: 30 yuan/Issue, 360 yuan/Year
WeChat
QR code
Lung cancer is the second most common cancer in the world and the main cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the predominant type. Epidermal growth factor receptor (EGFR) plays an important role in the development of NSCLC and has become an important target in the treatment of NSCLC. Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have been widely used in the targeted therapy of NSCLC and have been shown to effectively prolong the survival of patients with EGFR mutations, and their efficacy and prognosis are similar to those of EGFR mutations. 18F-deoxyglucose (FDG) PET/CT imaging can non-invasively evaluate NSCLC and is of great significance in predicting EGFR gene mutation status in NSCLC. The author reviews the recent advances in metabolic parameters and radiomics related to 18F-FDG PET/CT and EGFR mutation status.
PET absolute quantitative myocardial blood flow (MBF) imaging has significant clinical incremental value in the diagnosis, risk stratification, and prognosis evaluation of coronary artery disease. Still, it has not been widely used in the clinic due to the limitation of conventional positron myocardial perfusion imaging agents. The successful development of 2-tert-butylchloro-5[4-(2-fluoro-18F-ethoxymethyl) phenyl methoxy]-3(2H)-pyridazine ketone (18F-Flurpiridaz) has pioneered a new field of positron myocardial perfusion imaging agents. It has excellent absolute quantitative property in MBF and myocardial flow reserve (MFR) and has obvious advantages over traditional positron myocardial perfusion imaging agents in physical properties, myocardial extraction rate, and application convenience in the clinic, also, it has entered clinical phase Ⅲ research and has become the most promising 18F-labeled PET myocardial perfusion imaging agents. The authors review the research progress in 18F-Flurpiridaz PET absolute quantitative MBF imaging.
With the advancement of treating methods, the survival rate and survival time of tumor patients have improved significantly, but the cancer therapeutics-related cardiac dysfunction (CTRCD) seriously threatens the health of tumor survivors, among which the cardiotoxicity caused by anthracyclines (ANTs) is extremely common and can lead to irreversible heart damage. Early detection and timely treatment of cardiotoxicity caused by ANTs is essential for the recovery of cardiac function, so early detection of cardiotoxicity is of great clinical importance. This article focuses on new imaging methods that may help to detect cardiotoxicity caused by ANTs early, including myocardial strain imaging by echocardiography, myocardial strain imaging and myocardial tissue quantification imaging by cardiac magnetic resonance (CMR), and PET/CT imaging.
[Abstract]Overexpression of somatostatin receptors (SSTR), especially SSTR2 is a common feature of neuroendocrine neoplasms (NEN) and an ideal target for NEN molecular imaging and radionuclide-targeted therapy. In the past, researchers have been working on radionuclide-labeled SSTR agonists, and have successfully used them for clinical imaging and treatment of NEN. Recent studies have shown that radionuclide-labeled SSTR antagonists have better pharmacokinetic characteristics, higher tumor uptake rates, longer retention time, and higher image contrast obtained than agonists. It is more superior in molecular imaging and radionuclide-targeted therapy of NEN. In this paper, the research progress of radionuclide-labeled SSTR antagonists in the imaging and treatment of NEN is reviewed, in order to provide reference for the clinical diagnosis and treatment of NEN.
Dendrimer materials emerging in recent years have emerged as excellent materials for constructing nano-drug delivery systems due to their controllable structures and unique interactions with cell membranes and various active drug molecules. In this paper, the recently research progress of nano-drug delivery systems based on dendrimer materials for tumor targeted therapy is reviewed.
The impairment of salivary gland function is a common adverse reaction in radiotherapy and chemotherapy of head and neck tumors, which has a serious impact on the quality of life and treatment of patients. The incidence of salivary gland dysfunction increases with the increase of the incidence of head and neck diseases. Clear prevention and treatment methods are urgently needed. At present, a large number of domestic and foreign studies have revealed the possible mechanism of the impaired salivary gland function caused by radiation therapy and provided some prevention and treatment measures for clinical reference. This review focuses on the mechanism, symptoms, diagnosis and prevention of salivary gland dysfunction caused by 131I therapy.
Radioactive iodine (RAI) therapy is one of the critical treatments for differentiated thyroid cancer (DTC). The therapeutic effect is mainly related to the uptake ability of tumor lesions to RAI and radiosensitivity of the tumor cells. The sensitivity to RAI therapy may be improved by the two aforementioned directions in patients who are unsatisfactory in the evaluation of response to RAI therapy. By analyzing the relevant signaling pathways and molecular mechanisms that affect RAI therapy in DTC patients in recent years, the authors summarize the relevant mechanisms affecting RAI uptake, including sodium iodide symporter (NIS) expression and plasma membrane localization, as well as the DNA damage repair mechanisms that affect the radiosensitivity of RAI. It is expected to provide direction for the basic and clinical research of internal irradiation sensitization therapy for DTC patients.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovitis with unknown etiology, which often involves the facet joints of hands and feet, showing symmetrical and invasive arthritis changes, resulting in joint deformities and even loss of function. Different from traditional imaging methods, PET provides an imaging method at the cellular level and is a potential and highly sensitive method for the evaluation of synovitis. In this paper, clinical application and research progress of PET molecular probes in RA were reviewed in order to provide ideas for the diagnosis of RA.
Pancreatic cancer is a malignant tumor with higher malignancy, easy metastasis, rapid progression and poor prognosis, so early diagnosis, accurate staging and timely efficacy evaluation are crucial for patients with pancreatic cancer. As a novel multimodality imaging technology, integrated PET/MRI combines the advantages of high soft-tissue resolution, multi-sequences, multi-parameters of MRI and high sensitivity of PET metabolic imaging, it has potential application value in tumor staging efficacy evaluation, prognosis prediction, and recurrence monitoring of pancreatic cancer. Therefore, this paper reviews the advantages of 18F-fluorodeoxyglucose (FDG) PET/MRI and its clinical application and new progress in pancreatic cancer.
The easy Z-score imaging system (eZIS) is a statistical analysis method based on statistical parametric mapping (SPM) and three-dimensional stereotactic surface projection (3D-SSP) to assist the automatic diagnosis of cerebral blood perfusion SPECT imaging, which can be used in the diagnosis of nervous system diseases such as dementia, Parkinson disease, ataxia and motor neuron disease. Compared with other computer-aided analysis methods, eZIS can provide a normal database, and realize data sharing among different institutions through image conversion program, so that the future multi-center, large sample clinical research is possible. In this review, the clinical application of eZIS in the diagnosis of neurodegenerative dementia by cerebral blood perfusion SPECT is reviewed in order to improve clinicians' understanding of eZIS and promote its application in clinical and scientific research work.
A case of double lung multiple nodular amyloidosis with 18F-fluorodeoxyglucose (FDG) PET/CT imaging was reported. The characteristics of the disease were analyzed from clinical symptoms, imaging manifestations and pathological diagnosis. The understanding of pulmonary amyloidosis was deepened through literature review. The incidence of pulmonary nodular amyloidosis is low, the clinical symptoms are atypical, and it is difficult to differentiate from common lung tumors. It is suggested that the possibility of pulmonary nodular amyloidosis should be considered in the differential diagnosis of pulmonary nodules. Therefore, 18F-FDG PET/CT imaging is very important to evaluate the extent of double lung multiple nodular amyloidosis.
Malignant mesenchymoma(MM) is a a kind of soft tissue sarcoma composed of two or more different types of malignant mesenchymal components with a low incidence. The authors reported a special case of MM, which occurred in lung and was found by 18F-FDG PET/CT examination. The features of MM were analyzed from clinical symptoms, laboratory examination, imaging findings and related literature reports, in order to deepen clinicians' understanding of lung MM.
89Sr is a radiopharmaceutical for the treatment of bone metastasis, especially widespread bone metastasis of the whole body, but its clinical application is limited due to the adverse effect of myelosuppression. In addition to the radiobiological effects of 89Sr itself, high bone tumor burden of skeleton at 89Sr treatment, external radiotherapy before 89Sr treatment, chemotherapy and androgen suppression therapy before 89Sr treatment are the main factors of myelosuppression when using 89Sr to treat bone tumor metastasis. The authors analyzed the related factors of myelosuppression in the treatment of tumor bone metastasis with 89Sr.
Compared with men, women have different anatomical and physiological basis of coronary artery and neurohormone levels, resulting in more often from non-obstructive coronary microvascular dysfunction. Absolute quantitative myocardial perfusion imaging (MPI) is a noninvasive functional examination, which increases diagnosis performance, treatment evaluation, and prognostic evaluation of coronary artery disease (CAD). The change of heart rate and blood pressure in stress test, as the alternative indicator of autonomic nerve function, has a role in predicting blood perfusion parameters and adverse cardiovascular events. This review summarizes the gain value of stress MPI heart rate and blood pressure change on CAD diagnosis and risk assessment, so as to provide a basis for promoting the clinical application of stress MPI and formulating a diagnosis and treatment plan aimed to improving female autonomic nerve function.
With the wide application of PET in clinic, 18F-AlF-labeled peptide biomolecular probes are increasing in the spotlight. The procedure of 18F-AlF labeling of biomolecule conjugates is simple, valid and has tremendous potential. 18F-AlF-biomolecule conjugates PET imaging has high sensitivity and spatial resolution, with ideal quantification properties to trace biological targets of various tumors, so as to provide important information for accurate diagnosis and treatment of tumors. Part of them are in clinical research stage and show a broad scope in future clinical application. In this paper, the authors review the current process of 18F-AlF-labeled peptide molecular probes for PET tumor imaging.
Endometriosis is a common gynecological disease with a high incidence in women of childbearing age and has a wide range of sites in the body. Conventional imaging examinations and laparoscopy cannot effectively detect systemic, small and insidious endometriosis lesions. Radionuclide labeled choline analogs, estrogen analogs and somatostatin analogs have the potential to detect endometriosis lesions, and can provide functional and metabolic information of endometriosis lesions, which have special value for the diagnosis of endometriosis. In this paper, the diagnostic methods of endometriosis are reviewed, and the research progress of molecular imaging diagnosis of endometriosis is disscussed.
Multiple myeloma (MM) is a proliferous plasma cell malignancy. Abnormal proliferation of clonal plasma cells could not only involve skeletal system but also invade extramedullary and cause tissues or organs damage. 18F-fluorodeoxyglucose (FDG) PET/CT has become one of the most primary imaging methods for condition evaluation of MM by monitoring systemic glucose metabolism. The authors review the clinical application of 18F-FDG PET/CT in the diagnosis, staging, efficacy evaluation and prognosis prediction of MM, analyze its limitations, also introduce and prospect the application of new molecular probes in MM, in order to improve the clinicians' understanding of the clinical value of PET/CT in the diagnosis and treatment of MM, and further play the essential role of PET/CT in the clinical decision-making of MM.
Diabetes mellitus is a chronic and metabolic disease affecting more than 400 million people in the world. The pathogenesis of type 1 and type 2 diabetes mellitus is associated with the decrease or functional impairment of pancreatic β cells. With long-term hyperglycemia, diabetic patients will develop cardiovascular disease, neuropathy, diabetic foot and other complications. This paper reviews the application research progress of different types of PET and SPECT molecular imaging in the function monitoring of pancreatic β cells, and early diagnosis of diabetic complications such as coronary artery disease, cardiomyopathy, autonomic neuropathy, brain abnormalities and diabetic foot in diabetic patients.
The incidence rate of prostate cancer (PCa) ranks first among all male tumors, and PCa is prone to bone metastasis, which is characterized by pain, decreased quality of life, fractures, bone functional decline, impairment of hematopoiesis, and reduced survival rate. Bone scan index (BSI) is a method to quantitatively measure the severity of bone diseases. It can not only quantitatively evaluate the degree of bone tumor involvement in PCa patients, but also incorporate fully quantitative assessments of disease burden in associating bone scintigraphy post-treatment changes with clinical examination outcome, to assess progression or remisson of disease. In this paper, BSI, the development of automated BSI and its research in PCa are reviewed to provide reference for clinical practice.
Radiotherapy has become one of the main approaches in cancer treatment. However, tumor have radioresistance and normal tissues have radiation tolerant doses, both seriously affect the effect of cancer radiotherapy. It is of importance to develop radiation sensitizers to improve the radiosensitivity of tumor cells. Nuclear receptors are a kind of transcription factor superfamily, which are abundantly expressed in cells and participates in various pathophysiological processes. Recent studies have suggested that nuclear receptors and their related ligands may play important roles in tumor radioresistanace, which provide novel targets for radiosensitization. In this review, the research progress of nuclear receptors and related ligands in tumor radiosensitization is discussed.
The authors report a case of hepatic paragonimiasis with 18F-fluorodeoxyglucose PET/CT imaging, which is rare in clinic and easily misdiagnosed as hepatocellular carcinoma, cholangiocarcinoma or liver abscess. After entering the human body, paragonimiasis can lead to multi-system and multi-organ lesions. PET/CT as a systemic examination can find more organs involved, so as to make a more accurate diagnosis of liver paragonimiasis, strengthen understanding and reduce misdiagnosis.