About Journal
The International Journal of Radiation Medicine and Nuclear Medicine is one of the national medical journals which is administered by National Health Commission of the People’s Republic of China and published by Chinese Medical Association and Institute of Radiation Medicine.
Founded in 1977, the journal was formerly known as Foreign Medicine: Radiation Medicine and Nuclear Medicine. In 2006, it was renamed The International Journal of Radiation Medicine and Nuclear Medicine.
The journal takes the scientific research personnel and clinicians engaging in radiation medicine and nuclear medicine or the related areas as the target readers, the original article, review and reports in the international academic conference as the main forms. It particularly reports the new trends, recent developments, up-to-date technologies, and the newly-acquired experience in overseas and mainland in the fields of radiation medicine and nuclear medicine with the domestic situation, emphasizes article’s scientificalness and timeliness. This print specialized in experimental nuclear medicine, clinical nuclear medicine, radiobiology, clinical radiation medicine, radiation does, damage and radiation protection, radioactive labeling of drugs, molecular biology technology, radiation and security and related standards and regulations.
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Superintended by: National Health Commission of the People's Republic of China
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Institute of Radiation Medicine, Chinese Academy of Medical Sciences
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, Available online ,
doi: 10.3760/cma.j.cn121381-202309012-00367
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Abstract:
The study of the effects of ionizing radiation on the developing central nervous system and their mechanisms is an important subject for International Commission on Radiological Protection and United Nations Scientific Committee on the Effects of Atomic Radiation. Results from epidemiological investigations on the A-bomb survivors are the main basis for evaluating radiation risk. However, as these results reflect the biological effects of high-dose-rate single acute exposure, they cannot accurately reflect the biological effects of tritium beta particles under low-dose-rate continuous exposure. On the other hand, radiation sensitivity of the central nervous system changes with its developmental stage, resulting in different radiation risks under different exposure situations. This paper reviews the achievements obtained in a series of comprehensive studies led by Dr. Zhou's research group of the former Laboratory of Industrial Hygiene, Ministry of Public Health (now National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention) from 1980s to the present. In these studies, physiological development, neurobehavior, brain pathology, and neurobiochemistry in the prenatally exposed offspring, and electrophysiology and morphological and biochemical changes in brain cells in primary cultures were comprehensively studied using a total of 56 biological endpoints. This is the first time in the world that the same series of experimental systems, from molecules, cells, organs to the whole body, from tissue structure, neurobiochemistry, behavior to learning and memory functions, have been used to evaluate the risk of continuous low-dose tritium beta particle exposure on the developing central nervous system. These important achievements provide the most reliable and authoritative scientific basis for comprehensively and systematically evaluating the radiation risk of tritium beta particles on the developing central nervous system.
The study of the effects of ionizing radiation on the developing central nervous system and their mechanisms is an important subject for International Commission on Radiological Protection and United Nations Scientific Committee on the Effects of Atomic Radiation. Results from epidemiological investigations on the A-bomb survivors are the main basis for evaluating radiation risk. However, as these results reflect the biological effects of high-dose-rate single acute exposure, they cannot accurately reflect the biological effects of tritium beta particles under low-dose-rate continuous exposure. On the other hand, radiation sensitivity of the central nervous system changes with its developmental stage, resulting in different radiation risks under different exposure situations. This paper reviews the achievements obtained in a series of comprehensive studies led by Dr. Zhou's research group of the former Laboratory of Industrial Hygiene, Ministry of Public Health (now National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention) from 1980s to the present. In these studies, physiological development, neurobehavior, brain pathology, and neurobiochemistry in the prenatally exposed offspring, and electrophysiology and morphological and biochemical changes in brain cells in primary cultures were comprehensively studied using a total of 56 biological endpoints. This is the first time in the world that the same series of experimental systems, from molecules, cells, organs to the whole body, from tissue structure, neurobiochemistry, behavior to learning and memory functions, have been used to evaluate the risk of continuous low-dose tritium beta particle exposure on the developing central nervous system. These important achievements provide the most reliable and authoritative scientific basis for comprehensively and systematically evaluating the radiation risk of tritium beta particles on the developing central nervous system.
, Available online ,
doi: 10.3760/cma.j.cn121381-202302004-00364
Abstract:
Ovarian cancer is one of the common malignant tumors of female reproductive system. It is difficult to diagnose early, prone to relapse after initial treatment, and has a poor prognosis, so diagnosis and treatment still face great challenges. Imaging examination is an indispensable part in the diagnosis and treatment of ovarian cancer. Among them, nuclear medicine molecular imaging technology has become a highly potential non-invasive imaging method in the diagnosis and treatment of ovarian cancer. PET/CT has been widely used in the diagnosis, staging, treatment efficacy, prognosis, and recurrence evaluation of ovarian cancer. PET/MRI has shown significant advantages in the diagnosis and treatment of ovarian cancer due to its high soft tissue resolution and low radiation dose. SPECT/CT also plays an important role in the diagnosis and treatment of ovarian cancer due to the development of various new radioactive tracers. The authors review the application and research progress of PET/CT, PET/MRI and SPECT/CT about ovarian cancer, in order to further improve the value of molecular imaging technology in the diagnosis and treatment of ovarian cancer.
Ovarian cancer is one of the common malignant tumors of female reproductive system. It is difficult to diagnose early, prone to relapse after initial treatment, and has a poor prognosis, so diagnosis and treatment still face great challenges. Imaging examination is an indispensable part in the diagnosis and treatment of ovarian cancer. Among them, nuclear medicine molecular imaging technology has become a highly potential non-invasive imaging method in the diagnosis and treatment of ovarian cancer. PET/CT has been widely used in the diagnosis, staging, treatment efficacy, prognosis, and recurrence evaluation of ovarian cancer. PET/MRI has shown significant advantages in the diagnosis and treatment of ovarian cancer due to its high soft tissue resolution and low radiation dose. SPECT/CT also plays an important role in the diagnosis and treatment of ovarian cancer due to the development of various new radioactive tracers. The authors review the application and research progress of PET/CT, PET/MRI and SPECT/CT about ovarian cancer, in order to further improve the value of molecular imaging technology in the diagnosis and treatment of ovarian cancer.
, Available online ,
doi: 10.3760/cma.j.cn121381-202206012-00358
Abstract:
Objective To investigate the effects of long non-coding RNA microRNA503 host gene (LncRNA MIR503HG) on radiosensitivity of colon cancer cells by regulating the expression of miR-224-5pCHSY1. Methods 48 patients with colon cancer treated in our hospital from March 2019 to January 2022 were selected as the study subjects. According to the lesions after radiotherapy, they were divided into the radiation resistance group (n=23) and the radiosensitive group (n=25). The expressions of LncRNA MIR503HG and miR-224-5pCHSY1 in colon cancer tissues and cell lines (CCD841, COLO320, SW480, RKO, HCT116) were detected by qRT-PCR. The radiation-resistant colon cancer cell line HCT116R was constructed and divided into MIR503HG group, mimic-NC group, anti-miR-224-5p group, anti-miR-NC group, MIR503HG+miR-224-5p group and MIR503HG+miR-NC group. The targeting effect of LncRNA MIR503HG and miR-224-5pCHSY1 was verified by double luciferase report, and the cell survival rate and apoptosis rate were detected. The comparison of data between two groups was conducted using t-test, the comparison between multiple groups was conducted using one-way analysis of variance, and the comparison between multiple time points within the group was conducted using repeated measurement analysis of variance. Results Compared with radiosensitive group, the expression level of LncRNA MIR503HG in radiation resistance group was significantly lower (1.40±0.36 vs 0.72±0.17), and the expression level of miR-224-5pCHSY1 was significantly higher (1.06±0.25 vs 1.54±0.27) in radioresistant group. The relative expression of LncRNA MIR503HG in CCD841, COLO320, SW480, RKO, HCT116 and HCT116R cell lines was 2.38±0.06, 1.03±0.05, 0.87±0.03, 0.86±0.02, 0.77±0.04, 0.54 ±0.09 respectively. The expression of miR-224-5pCHSY1 was 0.38±0.06, 0.56±0.01, 0.59±0.02, 0.59±0.05, 0.63±0.04, 0.82±0.06 respectively, Compared with the normal cell line CCD841, the relative expression of LncRNA MIR503HG in colon cancer cell lines COLO320, SW480, RKO and HCT116 decreased significantly (t=2.061, 1.665, 4.058, 6.201, all P<0.01), while the expression of miR-224-5pCHSY1 increased significantly (t=1.238, 1.930, 2.037, 1.742, all P< 0.05). Compared with HCT116 cell line, the relative expression of LncRNA MIR503HG in HCT116R was significantly decreased, while the expression of miR-224-5pCHSY1 was significantly increased (t=5.720, 6.454, both P<0.05). When the irradiation doses were 4 Gy, 6 Gy and 8 Gy, the survival fraction (SF) of HCT116R cells in the MIR503HG group was significantly lower than that in the mimic-NC group (0.59±0.10 vs. 0.79±0.05, 0.40±0.08 vs. 0.60±0.10, 0.18±0.06 vs. 0.38±0.04), and the difference was statistically significant (t=1.064,1.937, 2.650, all P<0.05). After overexpression of LncRNA MIR503HG, the HCT116R SER of MIR503HG group was 1.399. The apoptosis rates of HCT116R cells in mimic-NC group, MIR503HG group, mimic-NC+4 Gy group and MIR503HG+4 Gy group were (8.10±0.23)%, (18.44±1.57)%, (17.33±2.35)% and (29.83±1.89)%, respectively. Compared with mimic-NC group, the apoptosis rate of HCT116R cells in MIR503HG group and mimic-NC+4 Gy group was significantly higher than that in MIR503HG group and mimic-NC+4 Gy group（t=2.003, 1.475, both P<0.05）. Compared with anti-miR-NC group, the luciferase activity of MIR503HG-Wt in anti-miR-224-5p group increased significantly (1.02±0.20 vs. 1.60±0.25), and the difference was statistically significant. After the mutation of miR-224-5pCHSY1 and LncRNA MIR503HG binding site, there was no significant difference in MIR503HG-Mut activity between anti-miR-224-5p group and anti-miR-NC group (0.97±0.25 vs. 1.00±0.22). Compared with mimic-NC group, the expression level of miR-224-5pCHSY1 in MIR503HG group was significantly lower than that in MIR503HG group (1.97±0.13 vs. 1.12±0.12). The expression level of miR-224-5pCHSY1 in anti-miR-224-5p group was significantly lower than that in anti-miR-NC group (1.99±0.19 vs. 0.92±0.18). When the irradiation doses were 4 Gy, 6 Gy and 8 Gy, the SF of HCT116R cells in anti-miR-224-5p group was significantly lower than that in anti-miR-NC group (0.59±0.08 vs. 0.79±0.12, 0.39±0.06 vs. 0.67±0.07, 0.19±0.04 vs. 0.52±0.04). The difference was statistically significant (t=1.281, 2.034, 2.911, all P<0.05). After inhibiting the expression of miR-224-5pCHSY1, the SER of HCT116R cells in anti-miR-224-5p group was 1.566. The apoptosis rates of anti-miR-NC group, anti-miR-224-5p group, anti-miR-NC+4 Gy group and anti-miR-224-5p+4 Gy group were 5.08+0.78, 14.48+1.21, 13.89+1.36 and 23.64+1.03, respectively. Compared with anti-miR-NC group, the apoptosis rates of anti-miR-224-5p group and anti-miR-NC+4 Gy group were significantly higher than those of anti-miR-NC+4 Gy group (t=2.067, 1.934, both P<0.05). Compared with anti-miR-NC+4 Gy group, the apoptosis rate of anti-miR-224-5p+4 Gy group was significantly higher than that of anti-miR-224-5p+4 Gy group (t=4.026, P<0.05). The SF of mimic-NC group, MIR503HG group, MIR503HG+miR-NC group and MIR503HG+miR-224-5p group were 0.82+0.17, 0.53+0.12, 0.54+0.11, 0.78+0.15, when the irradiation dose was 4 Gy, 0.66+0.13, 0.38+0.09, 0.35+0.08, 0.57+0.10 when the radiation dose was 6 Gy, and 0.49+0.10, 0.15+0.06, 0.13+0.05, 0.43+0.11 when the radiation dose was 8 Gy, respectively. Compared with mimic-NC group, the SF of HCT116R cells in MIR503HG group decreased significantly when the irradiation dose was ≥4 Gy (t=1.609, 1.533, 1.927, all P<1.533), and the SF of HCT116R cells in MIR503HG+miR-NC group decreased significantly (t=1.294, 1.490, 1.825, all P<0.05). Compared with MIR503HG+miR-NC group, the SF of HCT116R cells in MIR503HG+miR-224-5p group increased significantly when the irradiation dose was ≥ 4 Gy, and the difference was statistically significant (t=1.573, 1.204, 1.937, all P<0.05). After overexpression of miR-224-5pCHSY1, the SER of HCT116R cells in MIR503HG+miR-224-5p group was 0.824, which was significantly lower than that of MIR503HG. The apoptosis rates of mimic-NC group, MIR503HG group, MIR503HG+miR-NC group and MIR503HG+miR-224-5p group were 11.61±2.10, 24.97±0.91, 24.81±1.27 and 16.15 ±1.10, respectively. Compared with mimic-NC group, the apoptosis rate of HCT116R cells in MIR503HG group and MIR503HG+miR-NC group was significantly higher than that in MIR503HG group and MIR503HG+miR-NC group (t=2.304, 2.159, both P<0.05). Compared with MIR503HG+miR-NC group, the apoptosis rate of HCT116R cells in MIR503HG+miR-224-5p group was significantly lower than that in HCT116R group (t=2.067, P<0.05). Conclusion Overexpression of LncRNA MIR503HG can increase the radiosensitivity of colon cancer cells by inhibiting miR-224-5pCHSY1 expression.
, Available online ,
doi: 10.3760/cma.j.cn121381-202212013-00349
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Objective To explore the differences in ultrasound, MRI and molybdenum target imaging characteristics of different molecular subtypes of breast cancer. Methods A cohort of 212 female patients confirmed of breast cancer in Huizhou municipal central hospital from January 2018 to April 2022 were retrospectively analyzed. According to the results of pathology and immunohistochemistry, patients were grouped into four subtypes, including Luminal A, Luminal B, Her-2 over-expression and triple negative types. Among them, 31 Luminal A breast cancers, aged 31-85 years, with a mean of 49.2±10.8 years; 104 Luminal B breast cancers, aged 28-69 years, with a mean of 46.1±8.9 years; 45 HER-2 over-expression breast cancers, aged 28-68 years, mean of 49.6±10.1 years; 32 triple negative breast cancers, aged 24-64 years, with a mean of 48.5±8.5 years.The clinical and imaging features extracted from ultrasonography, MRI and mammography were recorded and statistically analyzed. Results Features including tumor's margin, the Alder grade of ultrasonography, the enhancement pattern of MRI, calcification in mammography, the axillary lymph node metastasis and patients' menopause status have statistically difference among four subtypes (P<0.05). The tumor's margin and patients' menopause status remained independent risk factors in multinomial logistic regression analysis (P<0.05).The area under the ROC curve of the diagnostic model was 0.635. Luminal A tumors mostly showed uneven internal echo, blurred margins, Alder grade 0/Ⅰ blood flow, heterogeneous MRI enhancement, mostly without calcification, punctate calcification, no menopause and lymph node metastasis at diagnosis. Luminal B tumors mostly showed uneven internal echo, burr marginal angle, Alder grade Ⅱ/Ⅲ blood flow, heterogeneous MRI enhancement, mostly with calcification, punctate calcification, menopause and lymph node metastasis at diagnosis. HER-2 over-expression mostly showed uneven internal echo, burr marginal angulations, Alder grade Ⅱ/Ⅲ blood flow, heterogeneous MRI enhancement, mostly with calcification, pleomorphic or linear-like calcification, unmenopausal and no lymph node metastasis at diagnosis. Triple negative tumors mostly showed uneven internal echo, marginal lobation, Alder grade 0/Ⅰ blood flow, ring-like MRI enhancement, mostly without calcification, pleomorphic or linear-like calcification, no menopause and without lymph node metastasis at diagnosis. There was no statistically difference in terms of patient age, shape, margin, posterior echo, background parenchymal enhancement, enhancement pattern,time intensity curve, DWI and mammographic density between different molecular types of breast cancer (all P>0.05). Conclusions The ultrasound, MRI and molybdenum target imaging characteristics have different molecular types, which can provide reference information for clinical diagnosis.
, Available online ,
doi: 10.3760/cma.j.cn121381-202212011-00348
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Objective To explore the consistency and influencing factors between diffusion-weighted imaging (DWI) and magnetic resonance angiography (MRA) in diagnosing acute cerebral infarct (ACI) patients. Methods 98 suspected ACI patients who received treatment at Laianjianing Hospital from January 2020 to February 2022 were selected as the study subjects and included in the training set. Among them, 58 were males and 40 were females, aged 45-80 (60.5±3.3) years old; Suspected ACI patients (33 cases) diagnosed and treated at Anjianing Hospital from March to October 2022 were selected according to the same criteria and included in the validation set. There were 18 males and 15 females, aged 42~79 (61.1±3.6) years old, for retrospective analysis. Using clinical comprehensive diagnosis as the "gold standard", analyze the diagnostic efficacy, imaging manifestations, and consistency of examination results of DWI and MRA. Two independent sample t-tests were used for inter group comparison of econometric data that conform to normal distribution; The inter group comparison of counting data was conducted using an χ2 test; Using Kappa test with multiple classification data to analyze the consistency between DWI and MRA in diagnosing ACI patients; Multiple Logistic regression analysis was used to screen for independent risk factors with inconsistent results between DWI and MRA examinations. Empower Stats and statistical software package "R" were used to draw a forest map, construct a risk column chart prediction model, and evaluate the model; The discriminability and calibration of the risk prediction model using the receiver operating characteristic (ROC) curve and the Hosmer-Lemeshow goodness-of-fit test; Evaluate the accuracy of the model using clinical decision curve analysis (DCA). Results Among the 74 patients diagnosed with ACI clinically, 73 (98.65%) were positive for DWI and 71 (95.95%) were positive for MRA. The difference in ADC values between the healthy (≤6 h, (1.06±0.24)×10−4 cm2/s; 6-24 h, (1.13±0.26)×10−4 cm2/s; 24-72 h, (1.05±0.17)×10−4 cm2/s) and affected (≤6 h, (0.59±0.11)×10−4 cm2/s; 6-24 h, (0.44±0.10)×10−4 cm2/s; 24-72 h, (0.53±0.09)×10−4 cm2/s) brain tissues of patients was statistically significant (t=10.227, 12.630, 7.646; all P<0.05); Within 24 h after the onset of the disease, the ADC value (≤6 h, (0.59±0.11)×10−4 cm2/s; 6-24 h, (0.44±0.10)×10−4 cm2/s) and rADC (≤6 h, (0.53±0.08); 6-24 h, (0.43±0.05)) in the affected side of the brain first significantly decreased (t=5.410, 5.569; all P<0.05), and then significantly increased (24~72 h, ADC: (0.53±0.09)×10−4 cm2/s, rADC: (0.49±0.06)) (t=2.274, 2.835; all P<0.05). There were 68 patients with consistent results between DWI and MRA (Group A), and 30 patients with inconsistent results (Group B). The consistency between DWI and MRA was good (Kappa=0.654, P<0.05). The results of multivariate Logistic regression analysis showed that onset time≤24 h, posterior circulation, and infarct size<2 cm were independent risk factors for inconsistent results between DWI and MRA diagnosis of ACI patients (OR=1.119, 1.169, 1.567; all P<0.05). The evaluation results of the risk column chart prediction model show that its discrimination [AUC of the training set and validation set were 0.930 (95%CI: 0.899~0.961) and 0.855 (95%CI: 0.812~0.898), respectively], accuracy, and effectiveness are all high. Conclusion DWI can clearly display the location and degree of ischemia of the lesion, while MRA can accurately locate the infarcted blood vessels and their stenosis. The consistency between the two examinations is good, and both are helpful for the diagnosis and evaluation of ACI, and the onset time, posterior circulation, and length of infarct lesion are risk factors that affect the consistency of diagnosis between the two.
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doi: 10.3760/cma.j.cn121381-202308005-00356
Abstract:
The popularization and application of nuclear fusion is an important national energy strategy. With the increase of tritium emission to the environment and the wide application of tritium in many fields, the opportunity for human beings to receive low-dose tritium irradiation also increases. In 2021, the International Commission on Radiological Protection (ICRP) issued No.148 publication on 'RADIATION WEIGHTING FOR REFERENCE ANIMALS AND PLANTS'. In the selected references and the RBE data of tritium β particles that reduce the reproductive function rate, the relevant literature in China and the results of tritium RBE were cited. Based on the No. 148 ICRP publication, this paper summarized the RBE value of low-energy tritium β particles on different biological endpoints, summarizes the contribution of China scholars to tritium research, and prospects the further research of tritium, aiming to promote the in-depth research of tritium and make due contributions to the radiation protection of tritium.
The popularization and application of nuclear fusion is an important national energy strategy. With the increase of tritium emission to the environment and the wide application of tritium in many fields, the opportunity for human beings to receive low-dose tritium irradiation also increases. In 2021, the International Commission on Radiological Protection (ICRP) issued No.148 publication on 'RADIATION WEIGHTING FOR REFERENCE ANIMALS AND PLANTS'. In the selected references and the RBE data of tritium β particles that reduce the reproductive function rate, the relevant literature in China and the results of tritium RBE were cited. Based on the No. 148 ICRP publication, this paper summarized the RBE value of low-energy tritium β particles on different biological endpoints, summarizes the contribution of China scholars to tritium research, and prospects the further research of tritium, aiming to promote the in-depth research of tritium and make due contributions to the radiation protection of tritium.
, Available online ,
doi: 10.3760/cma.j.cn121381-202309011-00366
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The authors summarize the research on the relative biological effectiveness (RBE) of nuclear fusion fuel tritium under low dose irradiation from the perspective of radiation protection. Two tritium irradiation methods, namely exponential decreasing dose rate and constant dose rate, were selected to observe and study the following biological indicators: dominant lethal mutation rate in oocytes, dominant lethal mutation rate in spermatocytes, dominant skeletal mutation rate, survival rate in primary oocytes and spermatogonia, as well as micronucleus cell rate in peripheral blood lymphocytes and polychromatic erythrocytes of fetal liver. The RBE value under the two tritium irradiation methods was calculated, and the factors influencing the RBE value were analyzed. The results showed that under the conditions of cumulative doses of 0.2, 0.3, 0.4, 0.5, and 0.6 Gy/10d, the RBE values under the tritium irradiation methods of exponential decreasing dose rate and constant dose rate were 2.9-4.2. For the purpose of radiation protection, it is recommended to set the RBE values of low linear energy transfer (LET) radiation on the biome to 3.0-3.5. If it is estimated that exposure to tritium β particles or other low LET radiation or closing to the derived reference level (DCRL) , a higher RBE value may be required for evaluation to a more accurate estimation of the radiation risk.
The authors summarize the research on the relative biological effectiveness (RBE) of nuclear fusion fuel tritium under low dose irradiation from the perspective of radiation protection. Two tritium irradiation methods, namely exponential decreasing dose rate and constant dose rate, were selected to observe and study the following biological indicators: dominant lethal mutation rate in oocytes, dominant lethal mutation rate in spermatocytes, dominant skeletal mutation rate, survival rate in primary oocytes and spermatogonia, as well as micronucleus cell rate in peripheral blood lymphocytes and polychromatic erythrocytes of fetal liver. The RBE value under the two tritium irradiation methods was calculated, and the factors influencing the RBE value were analyzed. The results showed that under the conditions of cumulative doses of 0.2, 0.3, 0.4, 0.5, and 0.6 Gy/10d, the RBE values under the tritium irradiation methods of exponential decreasing dose rate and constant dose rate were 2.9-4.2. For the purpose of radiation protection, it is recommended to set the RBE values of low linear energy transfer (LET) radiation on the biome to 3.0-3.5. If it is estimated that exposure to tritium β particles or other low LET radiation or closing to the derived reference level (DCRL) , a higher RBE value may be required for evaluation to a more accurate estimation of the radiation risk.
, Available online ,
doi: 10.3760/cma.j.cn121381-202309016-00362
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Tritium-labeled compounds are widely used in the field of medicine, especially tritium-labeled biomolecules, which can be used to analyze the metabolic processes of various molecules inside and within cells. This article introduces the synthesis methods of tritium-labeled compounds, provides an overview of the achievements and research progress of tritium-labeled biomolecules in the field of radiobiology and medical applications, with a focus on explaining the principles and applications of tritium-labeled thymidine nucleosides in determining DNA synthesis efficiency. Tritium-labeled compounds offer the advantages of simplicity, speed, intuitiveness, and accuracy in studying the distribution and metabolic processes of molecules such as DNA, RNA, and proteins within cells. Further development of analytical methods based on tritium-labeled compounds is of significant importance for a deeper understanding of molecular biology mechanisms.
Tritium-labeled compounds are widely used in the field of medicine, especially tritium-labeled biomolecules, which can be used to analyze the metabolic processes of various molecules inside and within cells. This article introduces the synthesis methods of tritium-labeled compounds, provides an overview of the achievements and research progress of tritium-labeled biomolecules in the field of radiobiology and medical applications, with a focus on explaining the principles and applications of tritium-labeled thymidine nucleosides in determining DNA synthesis efficiency. Tritium-labeled compounds offer the advantages of simplicity, speed, intuitiveness, and accuracy in studying the distribution and metabolic processes of molecules such as DNA, RNA, and proteins within cells. Further development of analytical methods based on tritium-labeled compounds is of significant importance for a deeper understanding of molecular biology mechanisms.
Accepted Manuscript
, Available online ,
doi: 10.3760/cma.j.cn121381-202308027-00350
Abstract:
Objective To study the effects of long-term tritiated water exposure on the growth and development of zebrafish offspring. Methods Embryos produced by wild-type AB strain zebrafish were exposed to 0, 102 Bq/L and 105 Bq/L tritiated water for long-term feeding as parents (F0 generation). After their sexual maturity, they reproduced, and the offspring obtained were recorded as F1 generation. The F1 generation zebrafish continued to be raised in tritiated water concentrations corresponding to the F0 generation. Observing the growth and development of F1 generation zebrafish, detecting autonomous movement and heart rate during embryonic stage, hatching rate, body length, reactive oxygen species (ROS) fluorescence intensity during seedling stage, total superoxide dismutase (T-SOD), malondialdehyde (MDA), total tritium content during juvenile stage, and egg production during adult stage. The t-test was used for inter group comparison of various detection indicators. Results The hatching rate of three groups of zebrafish in F1 generation were (90.66±0.05)%, (85.63±0.10)% and (78.06±0.15)%, respectively. Compared with the control group, there was no statistically significant difference in the hatching rate of F1 zebrafish between the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=0.785,1.370; P=0.462,0.220). The number of autonomous movement of three groups of zebrafish in F1 generation at 24 hours after fertilization was (12.93±2.70), (11.30±0.78) and (10.50±0.80) times/min, respectively. Compared with the control group, there was no statistically significant difference in the number of autonomous movements of F1 generation zebrafish in the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=1.008,1.499; P=0.370, 0.208); the number of autonomous movement of three groups of zebrafish at 36 hours after fertilization was (3.63±1.43), (4.50±1.15) and (5.40±3.55) times/min, respectively. Compared with the control group, there was no statistically significant difference in the number of autonomous movement of F1 generation zebrafish in the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=0.817, 0.799; P=0.460, 0.469); the heart rate of three groups of zebrafish at 48 hours after fertilization were (59.43±6.93), (65.00±3.30) and (61.23±4.55) times/20 s, respectively. Compared with the control group, there was no statistically significant difference in heart rate of F1 generation zebrafish in the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=1.256, 0.376; P=0.278, 0.726); the heart rate of three groups of zebrafish at 60 hours after fertilization were (69.87±2.71), (66.17±6.97) and (69.77±9.08) times/20 s, respectively. Compared with the control group, there was no statistically significant difference in heart rate of F1 generation zebrafish in the 102 Bq/L and 105 Bq/L tritiated water exposure groups(t=0.857, 0.018; P=0.440,0.986); the body length of three groups of zebrafish at 72 h after fertilization were (3.20±0.22), (3.32±0.08) and (3.29±0.06) mm, respectively. Compared with the control group, there was no statistically significant difference in body length of F1 generation zebrafish in the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=0.614,0.178; P=0.525,0.868); the body length of three groups of zebrafish at 84 hours after fertilization were (3.42±0.07), (3.46±0.11) and (3.40±0.04) mm, respectively. Compared with the control group, there was no statistically significant difference in body length of F1 generation zebrafish in the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=0.527,0.496; P=0.626,0.646). The ROS fluorescence intensity of three groups of zebrafish in F1 generation were (21.07±4.74), (23.71±7.73) and (23.19±5.32), respectively. Compared with the control group, there was no statistically significant difference in ROS fluorescence intensity of F1 generation zebrafish seedlings in the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=0.582, 0.593; P=0.582, 0.575). The T-SOD content of three groups of zebrafish in F1 generation at 45 d were (41.84±4.91), (42.30±5.04) and (36.97±5.26) U/mgprot, respectively. Compared with the control group, there was no statistically significant difference in the T-SOD content of F1 generation zebrafish in the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=0.112, 1.171; P=0.916,0.307); the T-SOD content of three groups of zebrafish at 60 d were (36.93±1.91), (34.07±3.02) and (33.54±1.87) U/mgprot, respectively. Compared with the control group, there was no statistically significant difference in the T-SOD content of F1 generation zebrafish in the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=1.397, 2.195; P=0.240,0.093); the MDA content of three groups of zebrafish at 45 d were (3.60±1.56), (3.59±0.44), and (2.95±0.58) nmol/mgprot, respectively. Compared with the control group, there was no statistically significant difference in the MDA content of F1 generation zebrafish in the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=0.007, 0.677; P=0.995, 0.536); the MDA content of three groups of zebrafish at 60 d were (4.00±0.52), (4.19±1.37), and (3.01±0.32) nmol/mgprot, respectively. Compared with the control group, there was no statistically significant difference in MDA content in F1 generation zebrafish exposed to 102 Bq/L tritiated water (t=0.229, P=0.830); the difference in MDA content in F1 generation zebrafish exposed to 105 Bq/L tritiated water was statistically significant (t=2.831, P=0.047). The eggs laid by three groups of zebrafish in F1 generation were (188±88), (204±22) and (220±40), respectively. Compared with the control group, there was no statistically significant difference in the egg production of F1 generation zebrafish in the 102 Bq/L and 105 Bq/L tritiated water exposure groups (t=0.400, 0.757; P=0.700, 0.477). Long term exposure to 105 Bq/L tritiated water can lead to the accumulation of tritium content in F1 generation zebrafish (the tritium content in fish body is (32.23±1.97) Bq/g at 60 d. Conclusion Long term exposure to 105 Bq/L tritiated water can lead to the accumulation of tritium in F1 generation zebrafish.
, Available online ,
doi: 10.3760/cma.j.cn121381-202301006-00360
Abstract:
Objective To explore the effect of melatonin on gut microbiota of a mouse model of γ-ray-induced radiation intestinal injury. Methods C57BL/6J male mice were divided into three groups using a simple random grouping method, namely, the control (without any treatment), irradiation (abdominal irradiation of mice at a dose of 13 Gy), and melatonin+irradiation groups (administration of melatonin to the mice for five consecutive days, followed by abdominal irradiation at a dose of 13 Gy), with five mice in each group. Mouse feces were collected 3 days after radiation, and gut microbiota analysis was conducted via 16S rDNA amplicon sequencing. Operational taxonomic units clustering and species annotation were analyzed using Uparse software. Sample complexity analysis and multisample comparative analysis were completed using the Qiime microbiome analysis platform. Results Pasteurella, Candidatus Arthromitus, and Bacteroides were the most abundant bacteria in the intestines of mice in the melatonin+irradiation group. Compared with the control group, the melatonin+irradiation group showed decreased abundance and diversity of gut microbiota in mice (both P<0.01) and increased community structure (P<0.001). From phylum to species, Proteobacteria phylum/class, Enterobacteriales order/family, Pasteurellales order/family/genus/species and Clostridiales class/order from phylum to species were the most abundant gut microbiota of mice in melatonin+irradiation group. In the construction of a symbiotic network of dominant species in mouse gut microbiota, the dominant interacting species under Proteobacteria, Actinobacteria, Bacteroidetes, and Firmicutes and their interacting relationships were identified. Conclusion The dominant species in the intestines of mice from melatonin+irradiation group might contribute to the relief of γ-ray-induced radiation intestinal injury mediated by melatonin.
, Available online ,
doi: 10.3760/cma.j.cn121381-202301009-00338
Abstract:
Objective To explore the prognostic evaluation of 18F-FDG PET/CT imaging RECIL standard for patients with non-Hodgkin's lymphoma (NHL) after autologous hematopoietic stem cell transplantation (ASCT) and the comparative study with Lugano standard. Methods The clinical data and imaging data of 86 NHL patients diagnosed by histopathological examination in Shanxi Provincial Cancer Hospital from October 2010 to November 2021 were retrospectively analyzed, including 63 male and 23 female, aged 34.0 (22.0, 47.0) years old. All patients underwent 18F-FDG PET/CT imaging before and after ASCT. According to the RECIL , all patients were evaluated for efficacy after ASCT. Based on the results of the patient efficacy evaluation, patients were divided into effective groups: complete response (CR), partial response (PR), and mild response (MiR); Invalid group: disease stability (SD), disease progression (PD). Pearson Chi-squared test and Mann Whitney U test were used to compare the differences in clinical indicators and 18F-FDG PET/CT parameters between the effective group and the ineffective group. Exploring the relevant factors affecting the prognosis of NHL patients after ASCT using univariate and multivariate Cox proportional risk regression analysis. According to the Lugano standard, all patients were evaluated for efficacy after ASCT. The patients were divided into complete remission group (CR), partial remission group (PR), and ineffective group (SD+PD). According to the RECIL , the patients were divided into complete remission group (CR), partial remission group (PR+MiR), and ineffective group (SD+PD). The 3-year overall survival period (OS) of the patients was followed up and analyzed. The Kappa test was used to evaluate the consistency of the two standards in evaluating the efficacy of the patients, Kaplan-Meier survival analysis was used to analyze the difference of 3-year OS rate between RECIL and Lugano standard in complete remission group, partial remission group and ineffective group, and Receiver operating characteristic was used to compare the predictive efficacy of RECIL and Lugano standard for 3-year OS rate. Results There was a statistically significant difference in SUVmax [1.3 (1.0, 2.0), 5.2 (4.8, 8.9)] between the effective group and the ineffective group after transplantation (Z=6.149, P<0.05). Patients in the effective group who received less than 2 chemotherapy regimens before transplantation [65.7% (44/67)] were higher than those in the ineffective group [21.1% (4/19)], and the difference was statistically significant (X2=11.949, P<0.05). Patients in the first-line consolidation treatment group [83.6% (56/67)] were higher than those in the ineffective group [31.6% (6/19)], The difference was statistically significant (X2=19.897, P<0.05). The results of univariate Cox proportional risk regression analysis showed that the RECIL (HR=0.021, 95%CI: 0.003-0.155, P<0.001), post-transplant SUVmax (HR=1.177, 95%CI: 1.087-1.274, P<0.001), number of pre-transplant chemotherapy regimens (HR=6.197, 95%CI: 1.338-28.711, P<0.05), and transplant timing (HR=8.808, 95%CI: 2.289-33.891, P<0.05) were prognostic factors for NHL patients. The results of multivariate Cox proportional risk regression analysis showed that the RECIL (HR=0.040, 95% CI: 0.004-0.439, P<0.05) was an independent risk factor for the prognosis of NHL patients; The RECIL and Lugano standard have good consistency in the efficacy evaluation of NHL patients after ASCT (Kappa=0.77, P<0.001). The Kaplan-Meier survival analysis results showed that there were statistically significant differences in 3-year OS rates between the complete remission group, partial remission group, and ineffective group according to the RECIL and Lugano standard (χ2=42.727, 33.646; both P<0.001). The AUC predicted by the RECIL for a 3-year OS rate is slightly higher than that of the Lugnao standard (0.884 vs. 0.865, all P>0.05). Conclusion The RECIL after ASCT can accurately evaluate the prognosis of NHL patients, and the RECIL and Lugano standard have similar prognostic evaluation effects on NHL patients after ASCT.
Accepted Manuscript
, Available online ,
doi: 10.3760/cma.j.cn121381-202309034-00365
Abstract:
Nuclear energy is an indispensable energy for human beings in the development of the world economy. Both the tritium produced in nuclear fission reactors and the fuel tritium adopted in nuclear fusion reactors are at risk of leakage and release. Therefore, the transfer and monitoring of tritium in the aerosphere, hydrosphere, pedosphere and biosphere is a pioneering and important topic in the field of radiation protection. This paper reviewed the classification of nuclear fusion energy, the source and transfer of fuel tritium in nuclear fusion, the monitoring of tritium in air, the analysis of tritium in water, the monitoring of tritium in soil, the analysis of tritium in food and biological samples, and the monitoring of tritium level in the environment, which can provide important reference for the healthy development of nuclear energy and tritium monitoring.
Nuclear energy is an indispensable energy for human beings in the development of the world economy. Both the tritium produced in nuclear fission reactors and the fuel tritium adopted in nuclear fusion reactors are at risk of leakage and release. Therefore, the transfer and monitoring of tritium in the aerosphere, hydrosphere, pedosphere and biosphere is a pioneering and important topic in the field of radiation protection. This paper reviewed the classification of nuclear fusion energy, the source and transfer of fuel tritium in nuclear fusion, the monitoring of tritium in air, the analysis of tritium in water, the monitoring of tritium in soil, the analysis of tritium in food and biological samples, and the monitoring of tritium level in the environment, which can provide important reference for the healthy development of nuclear energy and tritium monitoring.
, Available online ,
doi: 10.3760/cma.j.cn121381-202309026-00361
Abstract:
Tritium is the main raw material for nuclear fusion reaction, strengthening the research on the impact of tritium on the environment, the harm to living organisms and the radiation protection system has become an urgent issue. This paper mainly introduces the hazard and evaluation of tritium, tritium protection and management, and proposes the main issues of further tritium research.
Tritium is the main raw material for nuclear fusion reaction, strengthening the research on the impact of tritium on the environment, the harm to living organisms and the radiation protection system has become an urgent issue. This paper mainly introduces the hazard and evaluation of tritium, tritium protection and management, and proposes the main issues of further tritium research.
, Available online ,
doi: 10.3760/cma.j.cn121381-202308006-00354
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Tritium, a radionuclide, can enter the human body through various pathways, including the digestive tract, respiratory system, skin surface and wounds, resulting in varying degrees of internal radiation damage to human health. In this paper, the characteristics and radiation hazards of tritium are briefly introduced, and the clinical medical treatment data of internal tritium contamination caused by several accidents at home and abroad are reviewed. The key points of treatment and enlightenment for internal tritium contamination are put forward.
Tritium, a radionuclide, can enter the human body through various pathways, including the digestive tract, respiratory system, skin surface and wounds, resulting in varying degrees of internal radiation damage to human health. In this paper, the characteristics and radiation hazards of tritium are briefly introduced, and the clinical medical treatment data of internal tritium contamination caused by several accidents at home and abroad are reviewed. The key points of treatment and enlightenment for internal tritium contamination are put forward.
, Available online ,
doi: 10.3760/cma.j.cn121381-202302016-00357
Abstract:
Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome with complex mechanisms. The diagnosis of HFpEF is challenging due to the absence of specificity in early signs and symptoms. With the rapid development of related imaging techniques, further progress has been made in the study of the pathogenesis and pathophysiological changes of HFpEF, which opens up a new direction for the early diagnosis and clinical management of HFpEF. The paper reviews the current research status and progress on the imaging of HFpEF in recent years.
Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome with complex mechanisms. The diagnosis of HFpEF is challenging due to the absence of specificity in early signs and symptoms. With the rapid development of related imaging techniques, further progress has been made in the study of the pathogenesis and pathophysiological changes of HFpEF, which opens up a new direction for the early diagnosis and clinical management of HFpEF. The paper reviews the current research status and progress on the imaging of HFpEF in recent years.
, Available online ,
doi: 10.3760/cma.j.cn121381-202308004-00353
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In recent years, the radiation effects of tritium have received widespread attention. Medical emergency response to tritium-related accidents is a task with high requirements for specialized technology, wide coverage and wide impact. China's nuclear and radiation-related laws and regulations for emergency response have a perfect emergency response system and rescue management program. The author combines the characteristics of tritium radiation accidents and the relevant provisions of laws and regulations to analyze the three-level rescue system for medical emergency response to tritium accidents, the medical management of tritium accidents and the psychological assistance of the illuminated personnel, etc., in order to put forward constructive opinions for the medical emergency response and management of tritium-related accidents.
In recent years, the radiation effects of tritium have received widespread attention. Medical emergency response to tritium-related accidents is a task with high requirements for specialized technology, wide coverage and wide impact. China's nuclear and radiation-related laws and regulations for emergency response have a perfect emergency response system and rescue management program. The author combines the characteristics of tritium radiation accidents and the relevant provisions of laws and regulations to analyze the three-level rescue system for medical emergency response to tritium accidents, the medical management of tritium accidents and the psychological assistance of the illuminated personnel, etc., in order to put forward constructive opinions for the medical emergency response and management of tritium-related accidents.
, Available online ,
doi: 10.3760/cma.j.cn121381-202308028-00351
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Objective To study the effect of tritium water radiation dose on zebrafish at early developmental stages and integration with biological effects for the preliminary observation of dose–effect relationships Methods The real experimental conditions were simulated, the physical conditions were modeled, and the absorbed dose rates were calculated for 24 and 96 hour post fertilization (hpf）larvae in three different concentrations of tritium water: 3.7×103, 3.7×10, and 3.7×105 Bq/ml. The embryos or larvae turnover frequency and heartbeats of 24 and 96 hpf were observed and compared with those of the control group. Comparisons between multiple groups were analyzed by one-way ANOVA, and differences between the control and treatment groups were compared for significance using the LSD-t test Results With the extension of development time, the absorbed dose of zebrafish increased in three different concentrations of tritiated water: 24 hpf embryos corresponding to dose rates of 2.15×10, 2.21×102, 2.55×103 μGy/h; 96 hpf larvae corresponding to dose rates of 2.95×10, 3.03×102, 3.47×103 μGy/h. Comparison with control group, the results of 24 hpf embryo flipping showed that the significantly fewer embryos turned over in the tritium water-stained group whith 3.7×103 Bq/ml( t=3.94, P＜0.001); and 96 hpf larvae heart-beats changes significantly with tritium water concentration. Comparison with control group, the 3.7×103 Bq/ml tritium water-treated group had a significant decrease in heart rate(t=2.86, P=0.01), while the 3.7×105 Bq/ml tritium water-treated group had an increase in heart rate (t=−12.12, P<0.001). Conclusions Significant changes in embryonic turnover at 24 hpf and heart rate of larvae at 96 hpf were observed with changes in absorbed dose rate.
, Available online ,
doi: 10.3760/cma.j.cn121381-202308017-00352
Abstract:
Tritium is one of the common radioisotopes in the nuclear power plant. In heavy water reactors, tritium causes the higher internal exposure because of the reactor design. Third Qinshan Nuclear Power Plant (TQNPP) is the only heavy-water-reactor nuclear power plant in China, which has 2 CANDU6 reactors. Since TQNPP were put into commercial operation in 2003, TQNPP strictly performs area and individual tritium radiation monitoring, continuously improves monitoring techniques and personnel protection methods for tritium internal exposure, ensuring the occupational safety and healthy of plant staffs. From 2003~2022, none of incident caused by tritium internal exposure which the effective dose is above the regulatory limits was occurred, the average individual annual tritium internal effective dose is lower than 200 μSv, and the percentage of the average annual tritium internal exposure collective dose is 18.6%, which is lower than the average level of 20%~30% around the global heavy water reactor plants, showing that the management practice of tritium internal exposure monitoring and protection in TQNPP is effective.
Tritium is one of the common radioisotopes in the nuclear power plant. In heavy water reactors, tritium causes the higher internal exposure because of the reactor design. Third Qinshan Nuclear Power Plant (TQNPP) is the only heavy-water-reactor nuclear power plant in China, which has 2 CANDU6 reactors. Since TQNPP were put into commercial operation in 2003, TQNPP strictly performs area and individual tritium radiation monitoring, continuously improves monitoring techniques and personnel protection methods for tritium internal exposure, ensuring the occupational safety and healthy of plant staffs. From 2003~2022, none of incident caused by tritium internal exposure which the effective dose is above the regulatory limits was occurred, the average individual annual tritium internal effective dose is lower than 200 μSv, and the percentage of the average annual tritium internal exposure collective dose is 18.6%, which is lower than the average level of 20%~30% around the global heavy water reactor plants, showing that the management practice of tritium internal exposure monitoring and protection in TQNPP is effective.
, Available online ,
doi: 10.3760/cma.j.cn121381-202211025-00355
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Sclerosing angiomatoid nodular transformation (SANT) of spleen is a rare benign proliferative vascular lesion, histopathology is the "gold standard" for diagnosis. The author reported two cases of splenic SANT with 18F-fluorodeoxyglucose (FDG) PET/CT imaging, and analyzed the clinical, histopathological, therapeutic, and 18F-FDG PET/CT imaging aspects of the disease and deepened the understanding of this disease through literature review. A full understanding of the diagnostic criteria and imaging manifestations of SANT can help to obtain more information and make an accurate diagnosis.
Sclerosing angiomatoid nodular transformation (SANT) of spleen is a rare benign proliferative vascular lesion, histopathology is the "gold standard" for diagnosis. The author reported two cases of splenic SANT with 18F-fluorodeoxyglucose (FDG) PET/CT imaging, and analyzed the clinical, histopathological, therapeutic, and 18F-FDG PET/CT imaging aspects of the disease and deepened the understanding of this disease through literature review. A full understanding of the diagnostic criteria and imaging manifestations of SANT can help to obtain more information and make an accurate diagnosis.
, Available online ,
doi: 10.3760/cma.j.cn121381-202302010-00343
Abstract:
Prostate cancer (PCa) is the most common urinary tumor in men. Prostate specific membrane antigen (PSMA) is specific in PCa expression. Radionuclide labeled PSMA PET has unique advantages in early diagnosis, staging and treatment of PCa. This paper reviews the latest research progress of PSMA PET in the diagnosis and treatment of PCa.
Prostate cancer (PCa) is the most common urinary tumor in men. Prostate specific membrane antigen (PSMA) is specific in PCa expression. Radionuclide labeled PSMA PET has unique advantages in early diagnosis, staging and treatment of PCa. This paper reviews the latest research progress of PSMA PET in the diagnosis and treatment of PCa.
, Available online ,
doi: 10.3760/cma.j.cn121381-202211016-00346
Abstract:
Gastric cancer is one of the most common malignant tumors in China, with significant tumor heterogeneity in biology and genetics. PET is a non-invasive, real-time in vivo examination method. The use of PET imaging for early detection, treatment planning and efficacy monitoring is helpful to assist diagnosis and prognosis, improve the five-year survival rate of gastric cancer, and help clinicians to diagnose and identify its heterogeneity, so as to select individualized treatment plans. Therefore, the research of specific probes for gastric cancer based on PET imaging has been highly valued by researchers. This article summarizes the popular gastric cancer specific targets and their corresponding probes in current research, and describes and analyzes their development history and research results, hoping to provide reference and guidance for the development of new PET imaging probes for gastric cancer.
Gastric cancer is one of the most common malignant tumors in China, with significant tumor heterogeneity in biology and genetics. PET is a non-invasive, real-time in vivo examination method. The use of PET imaging for early detection, treatment planning and efficacy monitoring is helpful to assist diagnosis and prognosis, improve the five-year survival rate of gastric cancer, and help clinicians to diagnose and identify its heterogeneity, so as to select individualized treatment plans. Therefore, the research of specific probes for gastric cancer based on PET imaging has been highly valued by researchers. This article summarizes the popular gastric cancer specific targets and their corresponding probes in current research, and describes and analyzes their development history and research results, hoping to provide reference and guidance for the development of new PET imaging probes for gastric cancer.
Accepted Manuscript
, Available online ,
doi: 10.3760/cma.j.cn121381-202211026-00363
Abstract:
Occult thyroid carcinoma (OTC) is rare in differentiated thyroid carcinoma (DTC), and cases of OTC with extensive systemic metastasis are rarely reported at home and abroad. This paper reported a case of follicular carcinoma of thyroid with extensive metastasis from skeleton, lungs, adrenal gland and other parts of the whole body without primary focus, by analyzing the diagnosis and treatment process, laboratory examination, histopathological examination results and reviewing the relevant literature, the possible causes of OTC and the treatment scheme of extensive metastasis in the whole body were discussed.
Occult thyroid carcinoma (OTC) is rare in differentiated thyroid carcinoma (DTC), and cases of OTC with extensive systemic metastasis are rarely reported at home and abroad. This paper reported a case of follicular carcinoma of thyroid with extensive metastasis from skeleton, lungs, adrenal gland and other parts of the whole body without primary focus, by analyzing the diagnosis and treatment process, laboratory examination, histopathological examination results and reviewing the relevant literature, the possible causes of OTC and the treatment scheme of extensive metastasis in the whole body were discussed.
Accepted Manuscript
, Available online ,
doi: 10.3760/cma.j.cn121381-202304006-00359
Abstract:
Objective To evaluate the efficacy of AI in screening and qualitative diagnosis of pulmonary nodules. Methods Simple random sampling method was used to select the lung CT images of 355 patients (205 females, 150 males, age (55.1±12.2) years) from the pulmonary nodule case bank of Hebei Petro China Hospital from 2020 to 2021 and import them into the AI system. The diagnostic results of AI and 3 physicians with junior professional titles were compared, and 2 physicians with intermediate professional titles reviewed the CT images according to the double-blind principle. The consistent opinions of the two physicians with intermediate professional titles were used as the reference standard for the diagnosis of true nodules.Compare the sensitivity between the AI and junior physicians. On the other hand, 105 patients underwent preoperative CT guided puncture histopathological examination or postoperative histopathological examination after lung tissue resection. The histopathological examination results were used as the "gold standard" to compare the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rate of AI and the deputy chief physician in qualitative diagnosis of pulmonary nodules. Chi-square test or Fisher's exact probability test was used to compare counting data between groups. Results In this study, 355 patients (205 females and 150 males) were randomly selected for chest CT, and a total of 1072 true nodules were detected, among which 44 were incorrectly detected by AI and 9 were missed, the sensitivity was 99.16%(1063/1072). A total of 63 nodules were missed by primary physicians, and the sensitivity was 94.12%(1009/1072). In lung nodule screening, the sensitivity of AI was significantly higher than that of primary physicians (χ2=41.907, P<0.05).88 malignant nodules and 17 benign nodules were confirmed by pathology of 105 patients. Among them, there were 86 true positive nodules, 15 false positive nodules, 2 true negative nodules and 2 false negative nodules in qualitative diagnosis of pulmonary nodules by AI. There were 83 true positive nodules, 1 false positive nodule, 16 true negative nodules and 5 false negative nodules in qualitative diagnosis of pulmonary nodules by deputy chief physician.In terms of specificity and positive predictive value,deputy chief physician was significantly higher than AI (94.12 vs 11.76%, Fisher exact probability test, P<0.05; 98.81% vs 85.15%, χ2=9.172, P<0.05). In terms of sensitivity, deputy chief physician was lower than AI, but the difference was not statistically significant (94.32% vs 97.73%, χ2=0.595, P>0.05). In terms of negative predictive value, deputy chief physician was higher than AI, but the difference was not statistically significant (76.19% vs 50.00%, Fisher exact probability test, P>0.05).the accuracy rate of the qualitative diagnosis of pulmonary nodules by the deputy chief physician is higher than that of AI (94.29% vs 83.81%, χ2=8.796, P<0.05) for benign and malignant nodules. Conclusion AI has high sensitivity in the screening and qualitative diagnosis of pulmonary nodules, but its specificity, positive predictive value, negative predictive value, and accuracy rate are low. At this stage, in clinical work, physicians can use AI's good screening and detection value to help improve work efficiency, but it cannot replace the results of manual analysis as the standard for the diagnosis of pulmonary nodules. AI can be combined with physicians to provide more accurate information for clinical diagnosis and treatment.
Display Method:
2023, 47(9): 523-524.
doi: 10.3760/cma.j.cn121381-202309013-00347
Abstract:
2023, 47(9): 525-530.
doi: 10.3760/cma.j.cn121381-202210024-00340
Abstract:
Objective To investigate the effect of different kidney depth estimation formulas modified using SPECT/CT renal dynamic imaging on the calculation of the glomerular filtration rate (GFR) in living kidney transplant donors. Methods The clinical data of 127 healthy kidney transplant donors who underwent preoperative 99Tcm-diethylene triamine pentoacetic acid (DTPA) renal dynamic imaging in the First Affiliated Hospital of Xi'an Jiaotong University from October 2011 to December 2017 were retrospectively analyzed. Included 36 males and 91 females, aged (49.2±7.3) years. The computed GFR of kidney depth measured via CT was adopted as the standard reference standard. The Tønnesen and Itoh formulas were used to calculate kidney depth and the corresponding GFR and then compare them with the CT results. The measurement data that did not conform to the normal distribution were expressed as M (Q1, Q2), and the Wilcoxon rank sum test was used to compare between the renal depth calculated by each formula. Spearman correlation analysis and linear regression analysis were used to analyze the correlation between renal depth and the corresponding GFR of lelf and right kidney by each formula. Results The depth of the left and right kidneys from 127 healthy kidney transplant donors measured via CT [7.03(6.34, 7.67) cm, 7.21(6.51, 8.13) cm] was significantly higher than those obtained using the Tønnesen formula [5.66(5.30, 6.06) cm, 5.70(5.33, 6.10) cm] and the Itoh formula [6.70(6.33, 7.10) cm, 6.88(6.52, 7.26) cm], and the differences were statistically significant (left kidney: Z=−9.53, −3.77, both P<0.001; right kidney: Z=−9.73, −4.64, both P<0.001). The renal depth measured via CT was positively correlated with the renal depth calculated using the Tønnesen and Itoh formulas (left kidney: r=0.330, 0.331, both P<0.001; right kidney: r=0.359, 0.358, both P<0.001). The GFR of left and right kidneys that corresponded to the renal depth measured via CT [46.4(39.9, 52.0) ml/min, 46.0(40.5, 54.9) ml/min] was higher than those obtained using the Tønnesen formula [36.6(33.0, 41.9) ml/min, 36.2(32.1, 40.1) ml/min] and the Itoh formula [43.2 (39.4, 49.8) ml/min, 43.8 (39.4, 48.7) ml/min], and the differences were statistically significant (left kidney: Z=−9.52, −3.76, both P<0.001; right kidney: Z=−9.73, −4.75, both P<0.001). The CT measurement was positively correlated with the GFR values that corresponded to kidney depth estimates obtained using the Tønnesen and Itoh formulas (left kidney: r=0.476, 0.476, both P<0.001; right kidney: r=0.386, 0.539, both P<0.001). Conclusions The GFR calculated using the Tønnesen and Itoh formulas are suitable for the routine screening and evaluation of kidney diseases. For kidney transplant donors with more stringent requirements for renal GFR, kidney depth measured via CT should be used to correct the GFR calculated using SPECT/CT.
2023, 47(9): 531-537.
doi: 10.3760/cma.j.cn121381-202210002-00341
Abstract:
Objective To explore the imaging characteristics and clinical value of CT angiography (CTA) of the aorta in children with Takayasu arteritis (TA). Method We conducted a retrospective analysis of clinical data, imaging data, and laboratory examination results of 11 children with TA admitted to People’s Hospital of Xinjiang Uygur Autonomous Region from January 2016 to September 2022. The patients comprised 1 male and 10 females (8 adolescent girls). The age was (14.3±3.7) years. The course of the disease was (24.3±37.9) months. All children underwent chest and abdominal CT plain scan, aortic CTA, and post-processing examination, including multi-plane reconstruction, maximum density projection, volume reconstruction, and surface reconstruction. The imaging features of pediatric TA were analyzed, and the Numano classification was determined. Moreover, we observed the extent and degree of involvement of the aorta, branches, and pulmonary arteries, as well as the wall (thickening, calcification, high-density ring sign, low-density ring sign, and uneven enhancement), lumen (stenosis, dilation, and positive remodeling), and perivascular adipose tissue. Result Among the 11 children with TA, 9 were in the active phase (81.8%, 9/11), 10 were complicated with hypertension (90.9%, 10/11), 5 were accompanied with systemic symptoms (45.5%, 5/11), 4 were accompanied with cardiac symptoms (36.4%, 4/11), and 3 were accompanied with central nervous system symptoms (27.3%, 3/11), of which 1 case was complicated with hypertensive encephalopathy (9.1%, 1/11). There were 5 cases of elevated C-reactive protein and 5 cases of decreased hemoglobin (45.5%, 5/11), and there were 4 cases of elevated red blood cell sedimentation rate, white blood cell count, and platelet count (36.4%, 4/11). The most common types of Numano classification were IV and V, with a total of 10 cases (90.9%, 10/11); 11 cases (100%, 11/11) involved the descending aorta, 10 cases (90.9%, 10/11) involved the renal artery, 5 cases (45.5%, 5/11) involved the aortic arch and its branches, and 2 cases (18.2%, 2/11) involved the pulmonary artery. All 11 cases (100%, 11/11) of TA children showed increased wall density on CT plain scan, presenting as a high-density ring sign, and 3 cases (27.3%, 3/11) had wall calcification. Nine cases (81.8%, 9/11) of active children had perivascular adipose tissue opacity. In all 11 cases of CTA, the aorta and its branches were diffusely and multi-segmentally involved, with thickening of the wall (3.1±0.9) mm and uneven enhancement. Eight cases (72.7%, 8/11) showed a low-density ring sign in the inner wall. Renal artery stenosis in the aortic branches had the highest incidence (90.9%, 10/11), with 2 cases (18.3%, 2/11) of pulmonary artery involvement with stenosis and/or occlusion of the lumen and 4 cases of aortic dilation (36.4%, 4/11). Conclusions Aortic CTA can clearly display the aorta and its branches and pulmonary arteries. It can also comprehensively display the situation of affected blood vessels. Analyzing the CTA imaging features of children with TA is of great significance for the screening, diagnosis, and evaluation of the disease.
2023, 47(9): 538-544.
doi: 10.3760/cma.j.cn121381-202209009-00334
Abstract:
Objective To investigate the prophylactic effect of silicone on radiodermatitis during the treatment of keloid by using 90Sr-90Y applicator. Methods The clinical data of 175 patients who received 90Sr-90Y applicator for keloids at the Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2019 to June 2021 were retrospectively analyzed. The patients included 81 males and 94 females, with ages of (27.2±3.7) years. The patients were divided into the control group (57 cases), the 1 mm-thick silicone protection group (55 cases), and the 2 mm-thick silicone protection group (63 cases) by using the envelope random grouping method. All the patients were treated with multiple small-dose radiation therapy by using a 90Sr-90Y applicator. The skin around the lesion was respectively protected with 1 mm- and 2 mm-thick silicone in the 1 mm-thick and 2 mm-thick silicone protection groups. Radidermatitis for the three groups of patients was graded using the radidermatitis grading criteria of the Radiation Therapy Oncology Group. The incidence and severity of radiodermatitis were compared among the groups. The effects of the treatment course and silicone protection on the occurrence of severe radidermatitis were analyzed. Independent sample t-test (equal variances assumed) was used to compare the two groups for the measurement data in accordance with normal distribution. One-way ANOVA was adopted to compare the three groups. The chi-squared test was conducted to compare the count data in the three groups. Lastly, the factors that affected the efficacy of the treatment were analyzed via univariate Logistic regression analysis. Results No statistically significant difference was found in the incidence of radiodermatitis between the 1 mm-thick silicone protection group and the control group (83.6% vs. 89.5%, χ2=0.815, P=0.367). The incidence of radiodermatitis was significantly lower in the 2 mm-thick silicone protection group than in the control group and the 1 mm-thick silicone protection group (89.5% vs. 83.6% vs. 54.0%), and the differences were statistically significant (χ2=18.108, 11.738; both P<0.05). The severity of overall radiodermatitis was lower in the 1-mm thick silicone protection group than in the control group (1.05±0.65 vs. 1.37±0.75), and the difference was statistically significant (t=−2.409, P<0.05). The severity of radiodermatitis in the 2 mm-thick silicone protection group (0.63±0.66) was lower than that in the control group and the 1 mm-thick silicone protection group, and the differences were statistically significant (t=−5.749, −3.473; both P<0.05). The increase in the number of treatment courses augmented the risk of radiodermatitis (OR=2.348, 95%CI: 1.524–3.618, P<0.001). Meanwhile, the use of silicone with different thicknesses can reduce the risk of radiodermatitis (1 mm-thickness silicone: OR=0.273, 95%CI: 0.109–0.685, P<0.01; 2 mm-thickness silicone: OR=0.099, 95%CI: 0.034–0.293, P<0.001). Conclusion During the treatment of keloid with 90Sr-90Y applicator, the use of 2 mm-thick silicone to protect the surrounding normal skin tissue can significantly reduce the incidence and severity of radiodermatitis.
2023, 47(9): 545-554.
doi: 10.3760/cma.j.cn121381-202211010-00345
Abstract:
Objective To investigate the clinical value of a combined model of enhanced CT-based entropy features and traditional imaging features for the differential diagnosis of risk status in patients with thymic epithelial tumor (TET). Methods A retrospective analysis was conducted on the clinical data of 178 TET patients (83 males and 95 females; aged (52.7±12.4) years, ranged from 26 years to 83 years) confirmed by surgical and histopathological results at Jiangmen Central Hospital and the Fifth Affiliated Hospital of Sun Yat-sen University from October 2008 to May 2021 were retrospectively analyzed. They were divided into low-risk (A, AB, and B1 types) and high-risk (B2 and B3 types) groups according to histopathology subtypes. All patients were further divided into a training set (n=86), an internal validation set (n=51), and an external validation set (n=41). The internal and external validation sets were called the total validation set (n=92). The training and validation sets were used for the process construction and performance evaluation of the predictive model, respectively. The clinical characteristics of TET patients were recorded, and the traditional CT features of lesions were analyzed. Entropy features were extracted and selected from enhanced CT venous phase images by using software developed based on MATLAB R2016 platform. Mann-Whitney U test was used to select valuable entropy features. Extreme learning machine classification algorithm was adopted to calculate the different weights of entropy features and entropy signature value. Clinical model, entropy model, and combined model were constructed through Logistic analysis, and receiver operating characteristic curve was used to compare the diagnostic efficacy of the three predictive models. Results A total of 83 cases were included in the low-risk group (38 males and 45 females; aged (52.8±12.4) years, ranged from 26 years to 83 years), whereas 95 cases were in the high-risk group (45 males and 50 females; aged (52.0±12.0) years, ranged from 27 years to 80 years). Univariate analysis showed that the difference in peripheral invasion between the two groups in the training set was statistically significant (χ2=5.108, P=0.024). A total of 1 680 initial entropy features were extracted, and 21 core entropy features were ultimately selected. The entropy signature value of the low-risk group in the training set was 0.519±0.21, which was significantly lower than that of the high-risk group (0.997±0.23). The difference between the two groups was statistically significant (t=−9.747, P<0.001). The area under curve (AUC) of the entropy model in the training set, internal validation set, external validation set, and total validation set were 0.929(95%CI: 0.876–0.983), 0.832(95%CI: 0.723–0.941), 0.802(95%CI: 0.666–0.939), and 0.803(95%CI: 0.715–0.890), respectively. Results of multivariate Logistic regression analysis showed that peripheral invasion (OR=6.343; 95%CI: 1.009−36.604; P=0.039) and entropy signature value (OR=20.145; 95%CI: 5.887−68.936; P<0.001) were independent risk factors for predicting TET risk status. The combined model constructed by the two together had AUCs of 0.941(95%CI: 0.894–0.987), 0.871(95%CI: 0.775–0.968), 0.819(95%CI: 0.689–0.949), and 0.840(95%CI: 0.761–0.919) in the training set, internal validation set, external validation set, and total validation set, respectively. Conclusions The entropy feature based on enhanced chest-CT images can be used to assess the risk status of TET quantitatively. The combined model constructed by peripheral invasion and entropy signature value showed the highest diagnostic efficacy, which can accurately guide the preoperative treatment strategy of TET patients.
2023, 47(9): 555-561.
doi: 10.3760/cma.j.cn121381-202211019-00344
Abstract:
Objective To investigate the value of MRI DWI-based radiomics models for evaluating the treatment response in osteosarcoma after neoadjuvant chemoherapy. Methods A retrospective analysis was conducted on the medical records and imaging data of 41 patients with osteosarcoma (26 males and 15 females; aged (22.0±11.0) years, range of 11–49 years) who underwent MRI examinations before and after receiving neoadjuvant chemotherapy, and confirmed by postoperative histopathological examinations at the Third Hospital of Hebei Medical University from June 2015 to November 2017. In accordance with the postoperative histopathological examination results, patients with a tumor tissue necrosis rate of ≥90% were included in the good-efficacy group, and those with a necrosis rate of <90% were included in the poor-efficacy group. The apparent diffusion coefficient (ADC, denoted as ADC0, ADC1, and ADC2) were measured in all patients before neoadjuvant chemotherapy, within 5 days after the end of the first stage of chemotherapy, and after the completion of the entire chemotherapy. The differences in ADC were compared between the two groups. The region of interest of the lesion was manually delineated on DWI (b=1 000 s/mm2) and ADC images after the end of the first stage of chemotherapy, and the radiomics features were extracted. Data were divided into training set and validation set by using random grouping at 6∶4. The SMOTE algorithm was used to expand the data on the training set. The variance threshold, SelectKBest, and least absolute shrinkage and selection operator (LASSO) algorithm were used to screen the radiomics features. A radiomics model was constructed using a logistic regression classifier. Independent sample t-test or Wilcoxon rank sum test was used to compare the two groups. Receiver operating characteristic (ROC) curves were used to evaluate the predictive efficacy of traditional imaging (ADC) and radiomics models on the efficacy of neoadjuvant chemotherapy for osteosarcoma. Results A total of 10 and 31 cases were included in the good-efficacy and poor-efficacy groups, respectively. No statistically significant difference was found in the ADC0 value between the two groups ((0.95±0.05)×10−3 mm2/s vs. (1.05±0.05)×10−3 mm2/s, t=1.14, P>0.05)). The values of ADC1 and ADC2 in the good-efficacy group were higher than those in the poor-efficacy group, with statistical significance ((1.44±0.10)×10−3 mm2/s vs. (1.10±0.06)×10−3 mm2/s, t=−2.92, P<0.05; 1.68 (1.55, 1.85)×10−3 mm2/s vs. (1.33±0.06)×10−3 mm2/s, Z=−2.61, P<0.01). ROC curve analysis showed that when ADC1 ≥1.34×10−3 mm2/s, the sensitivity for evaluating the efficacy of neoadjuvant chemotherapy in osteosarcoma was 80%, the specificity was 81%, and the area under the curve (AUC) was 0.797 (95%CI: 0.629–0.965). When ADC2 ≥1.51×10−3 mm2/s, the sensitivity for evaluating the efficacy of neoadjuvant chemotherapy in osteosarcoma was 90%, the specificity was 71%, and the AUC was 0.777 (95%CI: 0.588–0.967). A total of 1 409 radiomics features were extracted from the DWI and ADC images after the end of the first stage of chemotherapy. They were randomly divided into training set and validation set at a ratio of 6∶4 (24 (good efficacy: 6, poor efficacy: 18)∶17 (good efficacy: 4, poor efficacy: 13)). The training set data were expanded to 70 (good efficacy: 20, poor efficacy: 50). After the radiomics features were screened, five optimal radiomics features were ultimately obtained, including InterquartileRange, Skewness, Uniformity, Median, and Maximum. Logistic regression classifier was used to construct a radiomics model. The ROC curves showed that in the training set, the AUC of the model for predicting the efficacy of neoadjuvant chemotherapy in osteosarcoma was 0.881 (95%CI: 0.811–0.942), with sensitivity of 90% and specificity of 74%. Meanwhile, in the validation set, the AUC was 0.769 (95%CI: 0.515–0.933), with sensitivity of 75% and specificity of 69%. Conclusion The radiomics model based on MRI DWI outperforms the traditional imaging (ADC) in evaluating the efficacy of neoadjuvant chemotherapy for osteosarcoma, showing great potential in clinical applications.
2023, 47(9): 562-567.
doi: 10.3760/cma.j.cn121381-202304024-00331
Abstract:
Objective To prepare human vascular endothelial growth factor (hVEGF) radioimmunoassay (RIA) and chemiluminescence immunoassay (CLIA) kits and evaluate their clinical value in diagnosis of early lung cancer and colorectal cancer. Methods A detection method was established according to the technical indices of the kits. The techniques for coating magnetic particles and 125iodine and acridine ester labeling with antibody were evaluated. Sensitivity, precision, and recovery of the kits were determined. The sensitivity and specificity of the kits in the diagnosis of early cancers (lung and colorectal cancers) were evaluated by testing cancer and normal serum samples. Independent sample t-test was used for inter-group comparison. Results The optimal ratios were as follows: 1 mL of magnetic particles to 1 mg of the antibody, 55.5 MBq 125iodine to 0.1 mg of the antibody, and 25 μg acridine ester to 0.2 mg of the antibody. The detection sensitivities of RIA and CLIA kits were 17.6 and 9.2 pg/mL respectively. For precision, the CLIA kit had slightly higher intra-batch variability and lower inter-batch variability than the RIA kit. The mean recovery levels of the RIA and CLIA kits were 103.28% and 101.85% respectively, and the latter had higher detection accuracy. The clinical sensitivity and specificity in the diagnosis of lung cancer and colorectal cancer were all above 90%. RIA kit and CLIA kit showed that the specificity of hVEGF in normal serum samples was 98.11% (104/106) and 99.06% (105/106), respectively.. There were significant differences in hVEGF between cancer patients and normal subjects (t=−16.695–−14.920, all P<0.01). Conclusions The technical indices of the hVEGF RIA and CLIA kits were good. The CLIA kit had higher sensitivity and specificity than the RIA kit and has clinical value in screening and auxiliary diagnosis of early lung and colorectal cancers.
2023, 47(9): 568-572.
doi: 10.3760/cma.j.cn121381-202302015-00342
Abstract:
18F-fluorodeoxyglucose (FDG) PET/MRI imaging of viable myocardium has always been concerned by clinicians, especially cardiologists. Both PET and MRI can play a unique value in the diagnosis and prognosis of ischemic cardiomyopathy. Integrated PET/MRI equipment provides a new platform for exploring its integrated value. By reviewing the pathophysiology of ischemic cardiomyopathy, the characteristics of PET myocardial imaging and the clinical application of MRI, and combing the research progress in related fields in the past ten years, the author reviews the characteristics and clinical value of PET/MRI viable myocardial imaging, so as to provide reference for the clinical scientific research of PET/MRI viable myocardial imaging.
18F-fluorodeoxyglucose (FDG) PET/MRI imaging of viable myocardium has always been concerned by clinicians, especially cardiologists. Both PET and MRI can play a unique value in the diagnosis and prognosis of ischemic cardiomyopathy. Integrated PET/MRI equipment provides a new platform for exploring its integrated value. By reviewing the pathophysiology of ischemic cardiomyopathy, the characteristics of PET myocardial imaging and the clinical application of MRI, and combing the research progress in related fields in the past ten years, the author reviews the characteristics and clinical value of PET/MRI viable myocardial imaging, so as to provide reference for the clinical scientific research of PET/MRI viable myocardial imaging.
2023, 47(9): 573-578.
doi: 10.3760/cma.j.cn121381-202301008-00335
Abstract:
Thyroid-associated ophthalmopathy (TAO) leads a significant negative impact on patients' quality of life, mental health and community economy. Treatment in the early active stage of the disease will achieve better efficacy. At present clinical activity score (CAS) is the mainly method of judging disease activity, but it has many shortcomings. Recent studies have suggested that 99Tcm-diethylene triamine pentaacetic acid (DTPA) orbital SPECT/CT shows important value in the early diagnosis, treatment and follow-up of TAO. It can complement with CAS and has a broad application prospect. The authors summarize the current research progress in this field and highlight the need for more research to establish a standardized consensus on collection method and result analysis. Investigating a new tool to judge disease activity which can combine 99Tcm-DTPA orbital SPECT/CT with the artificial intelligence will more accurately and conveniently guide the clinical practice.
Thyroid-associated ophthalmopathy (TAO) leads a significant negative impact on patients' quality of life, mental health and community economy. Treatment in the early active stage of the disease will achieve better efficacy. At present clinical activity score (CAS) is the mainly method of judging disease activity, but it has many shortcomings. Recent studies have suggested that 99Tcm-diethylene triamine pentaacetic acid (DTPA) orbital SPECT/CT shows important value in the early diagnosis, treatment and follow-up of TAO. It can complement with CAS and has a broad application prospect. The authors summarize the current research progress in this field and highlight the need for more research to establish a standardized consensus on collection method and result analysis. Investigating a new tool to judge disease activity which can combine 99Tcm-DTPA orbital SPECT/CT with the artificial intelligence will more accurately and conveniently guide the clinical practice.
2023, 47(9): 579-583.
doi: 10.3760/cma.j.cn121381-202206011-00337
Abstract:
Keloid is a fibroproliferative disease, usually caused by abnormal wound healing, and it is easy to recur after surgical resection. In recent years, the application of radioactive adjuvant therapy has greatly reduced the recurrence rate of keloids after resection. This article reviews several brachytherapy methods commonly used in clinical practice, and provides references for clinicians and researchers in related fields in the treatment of keloids.
Keloid is a fibroproliferative disease, usually caused by abnormal wound healing, and it is easy to recur after surgical resection. In recent years, the application of radioactive adjuvant therapy has greatly reduced the recurrence rate of keloids after resection. This article reviews several brachytherapy methods commonly used in clinical practice, and provides references for clinicians and researchers in related fields in the treatment of keloids.
2023, 47(9): 584-587.
doi: 10.3760/cma.j.cn121381-202209006-00339
Abstract:
The authors reported a case of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes (POEMS) syndrome located in the right iliac bone by 18F-fluorodeoxyglucose (FDG) PET/CT. The authors summarized the diagnostic criteria and 18F-FDG PET/CT imaging manifestations of POEMS syndrome through literature review. Although 18F-FDG PET/CT in POEMS syndrome has been well reported, imaging manifestations involving only the right iliac bone are rare. Understanding the diagnostic criteria, clinical manifestations and laboratory findings of POEMS syndrome can help to obtain more information and make an accurate diagnosis.
The authors reported a case of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes (POEMS) syndrome located in the right iliac bone by 18F-fluorodeoxyglucose (FDG) PET/CT. The authors summarized the diagnostic criteria and 18F-FDG PET/CT imaging manifestations of POEMS syndrome through literature review. Although 18F-FDG PET/CT in POEMS syndrome has been well reported, imaging manifestations involving only the right iliac bone are rare. Understanding the diagnostic criteria, clinical manifestations and laboratory findings of POEMS syndrome can help to obtain more information and make an accurate diagnosis.
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