2009 Vol. 33, No. 6
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2009, 33(6): 321-326.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.001
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Abstract:
Molecular nuclear medicine including PET and SPECT is one of the most important parts of the molecular imaging.The combinations of molecular unclear medicine with CT,MRI,ultrasound or optical imaging and synthesis of muhimodality radiopharmaceuticals are the major trends of the development of nuclear medicine.Molecular nuclear medicine has more and more important value on the monitoring of response to biology involved gene therapy or stem cell therapy and the developments of new drug.
Molecular nuclear medicine including PET and SPECT is one of the most important parts of the molecular imaging.The combinations of molecular unclear medicine with CT,MRI,ultrasound or optical imaging and synthesis of muhimodality radiopharmaceuticals are the major trends of the development of nuclear medicine.Molecular nuclear medicine has more and more important value on the monitoring of response to biology involved gene therapy or stem cell therapy and the developments of new drug.
2009, 33(6): 327-330.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.002
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Objective To investigate the binding characteristics of 18F-fluorodeoxyglucose(18F-FDG) and 18F-fluorodeoxythymidine(18F-FLT) with human lymphoma cell Raji and the differences between them.Methods The binding rates of 18F-FDG and 18F-FLT was measured under different conditions:1×105~107 cells,1.85~29.6 kBq 18F-FDG or 18F-FLT, 0~11.1 mmol/L glucose levels and 20~120 min to measure.Results The binding rate of 18F-FDG was(50.42±1.07) % at the condition of l×107 cells, 3.7 kBq 18F-FDG,0~2.78 mmol/L glucose levels, 100 min, while 18F-FLT was(59.48 ±0.77) % at the same conditions. The difference of binding rates between 18F-FDG and 18F-FLT was significant(F=1192.805, P<0.001).Conclusion The uptake of 18F-FDG and 18F-FLT in human lymphoma Raji cell is high, and at the same condition, the uptake rate of 18F-FLT is higher than 18F-FDG.
Objective To investigate the binding characteristics of 18F-fluorodeoxyglucose(18F-FDG) and 18F-fluorodeoxythymidine(18F-FLT) with human lymphoma cell Raji and the differences between them.Methods The binding rates of 18F-FDG and 18F-FLT was measured under different conditions:1×105~107 cells,1.85~29.6 kBq 18F-FDG or 18F-FLT, 0~11.1 mmol/L glucose levels and 20~120 min to measure.Results The binding rate of 18F-FDG was(50.42±1.07) % at the condition of l×107 cells, 3.7 kBq 18F-FDG,0~2.78 mmol/L glucose levels, 100 min, while 18F-FLT was(59.48 ±0.77) % at the same conditions. The difference of binding rates between 18F-FDG and 18F-FLT was significant(F=1192.805, P<0.001).Conclusion The uptake of 18F-FDG and 18F-FLT in human lymphoma Raji cell is high, and at the same condition, the uptake rate of 18F-FLT is higher than 18F-FDG.
2009, 33(6): 330-334.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.003
Abstract:
Radionuclide labelled somatostatin analogues have been widely used in the detection of neuro-endocrine tumors. Till now, most of somatostatin analogues only have high affinity to somatostatin receptor 2(SSTR2), further clinical applications was limitted. A new generation of somatostatin analogues such as 1,4,7,10-tetraazacyclodocecane-N,N',N",N'"-tetaraacetic acid-Nal3-octertide(DOTA-NOC) etc,binding to somatostatin receptors not only SSTR2 but other subtypes has been used mainly in preclinical study. In this review, we discussed these new somatostatin analogues, chelating agent, and their new labelled compounds, these new radionuclide labelled somatostatin analogues may hold great promise for the receptor-mediated tumor imaging and treatments.
Radionuclide labelled somatostatin analogues have been widely used in the detection of neuro-endocrine tumors. Till now, most of somatostatin analogues only have high affinity to somatostatin receptor 2(SSTR2), further clinical applications was limitted. A new generation of somatostatin analogues such as 1,4,7,10-tetraazacyclodocecane-N,N',N",N'"-tetaraacetic acid-Nal3-octertide(DOTA-NOC) etc,binding to somatostatin receptors not only SSTR2 but other subtypes has been used mainly in preclinical study. In this review, we discussed these new somatostatin analogues, chelating agent, and their new labelled compounds, these new radionuclide labelled somatostatin analogues may hold great promise for the receptor-mediated tumor imaging and treatments.
2009, 33(6): 335-336,375.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.004
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Objective To observe the anti-tumor effect of elemene tricarbonyl rhenium-188 complex(ETRC) on small cell lung cancer(SCLC) bearing nude mice model, and also its biodistribution, tumor targeting features. Methods ETRC was synthesized from β-elemene, which is a active ingredient in Chinese herbal medicine. Twelve SCLC bearing nude mice were infused ETRC through tail vein. The radioactivity of tumor and diferent organs were measured in various time phase. And %ID/g was calculated. All 20 mice models were divided into four groups randomly, concluding ①Physiological saline infusion group;②Elemene infusion group; ③188Re infusion group; ④ETRC infusion group. Twenty four days after infusion, the volume and weight of tumors were measured and analyzed. Results Six hours after infusion of ETRC, the highest radioactive uptake[(6.35±0.33) %ID/g] was found in tumor mass. Ratio of tumor/blood was 2.59, ratio of tumor/liver was 4.07 and ratio of tumor/spleen was 3.87. The volume and weight of tumor in four groups were:groups ①:(2.945±0.567)cm3,(5.438±1.232)g; groups ②:(1.860±0,263)cm3,(4,876±0.621)g; groups ③:(1.861 ±0,896)cm3,(4.691 ±1.595)g; groups ④:(0.601±0.152)cm3,(1.602±0.194)grespectively. There was significant difference between ETRC infusion group and each of other groups. Conclusion ETRC can effectively depress the growth of tumor and it is a promising agent for the treatment of SCLC.
Objective To observe the anti-tumor effect of elemene tricarbonyl rhenium-188 complex(ETRC) on small cell lung cancer(SCLC) bearing nude mice model, and also its biodistribution, tumor targeting features. Methods ETRC was synthesized from β-elemene, which is a active ingredient in Chinese herbal medicine. Twelve SCLC bearing nude mice were infused ETRC through tail vein. The radioactivity of tumor and diferent organs were measured in various time phase. And %ID/g was calculated. All 20 mice models were divided into four groups randomly, concluding ①Physiological saline infusion group;②Elemene infusion group; ③188Re infusion group; ④ETRC infusion group. Twenty four days after infusion, the volume and weight of tumors were measured and analyzed. Results Six hours after infusion of ETRC, the highest radioactive uptake[(6.35±0.33) %ID/g] was found in tumor mass. Ratio of tumor/blood was 2.59, ratio of tumor/liver was 4.07 and ratio of tumor/spleen was 3.87. The volume and weight of tumor in four groups were:groups ①:(2.945±0.567)cm3,(5.438±1.232)g; groups ②:(1.860±0,263)cm3,(4,876±0.621)g; groups ③:(1.861 ±0,896)cm3,(4.691 ±1.595)g; groups ④:(0.601±0.152)cm3,(1.602±0.194)grespectively. There was significant difference between ETRC infusion group and each of other groups. Conclusion ETRC can effectively depress the growth of tumor and it is a promising agent for the treatment of SCLC.
2009, 33(6): 337-340.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.005
Abstract:
Epilepsy is a very complicate and synthetic disease which influence patients intelligence and daily life acutely. But the cure rate of epilepsy is much low. One of the results is precise localization of disease which result in epilepsy. Today the main methods are electroencephalogram, magnetic resonance imaging, magnetic resonance spectroscopy and PET cerebral imaging. PET cerebral imaging can locate epileptic foci of epilepsy from the brain organization metabolism, blood, the bio-chemical, function and oxygen consume, the chemistry pass quality and nerve receptor. It raises the rate of checking the epileptic foci and indicates a direction for the next treatments of epilepsy.
Epilepsy is a very complicate and synthetic disease which influence patients intelligence and daily life acutely. But the cure rate of epilepsy is much low. One of the results is precise localization of disease which result in epilepsy. Today the main methods are electroencephalogram, magnetic resonance imaging, magnetic resonance spectroscopy and PET cerebral imaging. PET cerebral imaging can locate epileptic foci of epilepsy from the brain organization metabolism, blood, the bio-chemical, function and oxygen consume, the chemistry pass quality and nerve receptor. It raises the rate of checking the epileptic foci and indicates a direction for the next treatments of epilepsy.
2009, 33(6): 341-343.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.006
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Objective To study the changing and its interaction of determining serum gastrin levels and Helicobacter pylori test during chronic atrophic gastritis into gastric cancer. Methods RIA and 13C-urea breath test(13C-UBT) determined the Gs levels and Hp infection rate in 63 rate cases(first visit) patients,48 cases(after one year return visit) patients, 35 cases(after three year return visit) patients and 30 cases(after five years return visit) patients with CAG 90 cases patients with gastric cancer(and different position) and 61 cases normal controls. They all were done study compared. Results Serum Gs levels in 63 cases(first visit) patients, 48 cases(after one year return visit) patients, 35 cases(after three year return visit) patients and 30 cases(after five years return visit) patient with CAG were significantly higher(t=4.716, 5.218,5.624, 6,179, 6,572, all P<0.01) than 61 cases normal controls, but Hp infection rate were 65,1%, 70,8%,82.9%, 86.7% and 88.8%. There was no distinct difference between serum Gs in patients with sinuses ventriculi cancer and normal controls(t=1.560, P>0.05). Serum Gs levels in 90 cases with gastric cancer(and different position) was significantly higher(t=4.221, P<0.05; t=4.436, P<0.01) than 61 cases normal controls and the highest serum Gs level was found in cancer of cardia and fundus. And Hp infection rate was 88.8%. Conclusion The early diagnosis on gastric cancer was very important by determining serum Gs and Hp infection rate.
Objective To study the changing and its interaction of determining serum gastrin levels and Helicobacter pylori test during chronic atrophic gastritis into gastric cancer. Methods RIA and 13C-urea breath test(13C-UBT) determined the Gs levels and Hp infection rate in 63 rate cases(first visit) patients,48 cases(after one year return visit) patients, 35 cases(after three year return visit) patients and 30 cases(after five years return visit) patients with CAG 90 cases patients with gastric cancer(and different position) and 61 cases normal controls. They all were done study compared. Results Serum Gs levels in 63 cases(first visit) patients, 48 cases(after one year return visit) patients, 35 cases(after three year return visit) patients and 30 cases(after five years return visit) patient with CAG were significantly higher(t=4.716, 5.218,5.624, 6,179, 6,572, all P<0.01) than 61 cases normal controls, but Hp infection rate were 65,1%, 70,8%,82.9%, 86.7% and 88.8%. There was no distinct difference between serum Gs in patients with sinuses ventriculi cancer and normal controls(t=1.560, P>0.05). Serum Gs levels in 90 cases with gastric cancer(and different position) was significantly higher(t=4.221, P<0.05; t=4.436, P<0.01) than 61 cases normal controls and the highest serum Gs level was found in cancer of cardia and fundus. And Hp infection rate was 88.8%. Conclusion The early diagnosis on gastric cancer was very important by determining serum Gs and Hp infection rate.
2009, 33(6): 343-346.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.007
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Objective To evaluate 99Tcm-diethylenetriamine-pentaacetic acid(99Tcm-DTPA) renal dynamic imaging in judgment of the renal function inpatients with diabetes mellitus(DM) so as to provide reference for clinical treatment and prognosis predicting. Methods Ninety patients with DM were divided into four groups according to the values of urinary albumin excretion rate(UAER).①Group DM,:UAER<20μg·min-1, 25 cases.②Gruop DM2:UAER 20-200μg·min-1, 24 cases.③Group DM;UAER>200μg·min-1, 23 cases.④a renal function failure group(DM4), 18 cases. Fourty healthy people were chosen as normal control(NC) group.99Tcm-DTPA radionuclide renal dynamic imaging of glcmerular filtration rate(GFR) was performed and the levels of serum creatinine(SCr), blood urea nitrogen(BUN) and blood β2-microglobulin(β2-MG) were measured in the five groups. Results GFR were significantly increased in group DM1 than those in NC(t=12.5, P<0.01).In group DM2 GFR was not different from NC. The half activity time(T1/2) of the renogram was significantly prolonged. The 20 min retention rate(C20) of the renogram increased compared with NC. In group DM3 and DM4, GFR was remarkably decreased. The peak time(TP) of the renogram delayed. T1/2 distinctly prolonged and C20 increased,comparing with NC(r=-0.497,P<0.05). Conclusion Radionuclide renal dynamic imaging is helpful for the evaluation of renal damage in early stage of diabetic nephropathy(DN),judge the injury of the renal function and provide reference for clinical t treatment and follow-up.
Objective To evaluate 99Tcm-diethylenetriamine-pentaacetic acid(99Tcm-DTPA) renal dynamic imaging in judgment of the renal function inpatients with diabetes mellitus(DM) so as to provide reference for clinical treatment and prognosis predicting. Methods Ninety patients with DM were divided into four groups according to the values of urinary albumin excretion rate(UAER).①Group DM,:UAER<20μg·min-1, 25 cases.②Gruop DM2:UAER 20-200μg·min-1, 24 cases.③Group DM;UAER>200μg·min-1, 23 cases.④a renal function failure group(DM4), 18 cases. Fourty healthy people were chosen as normal control(NC) group.99Tcm-DTPA radionuclide renal dynamic imaging of glcmerular filtration rate(GFR) was performed and the levels of serum creatinine(SCr), blood urea nitrogen(BUN) and blood β2-microglobulin(β2-MG) were measured in the five groups. Results GFR were significantly increased in group DM1 than those in NC(t=12.5, P<0.01).In group DM2 GFR was not different from NC. The half activity time(T1/2) of the renogram was significantly prolonged. The 20 min retention rate(C20) of the renogram increased compared with NC. In group DM3 and DM4, GFR was remarkably decreased. The peak time(TP) of the renogram delayed. T1/2 distinctly prolonged and C20 increased,comparing with NC(r=-0.497,P<0.05). Conclusion Radionuclide renal dynamic imaging is helpful for the evaluation of renal damage in early stage of diabetic nephropathy(DN),judge the injury of the renal function and provide reference for clinical t treatment and follow-up.
2009, 33(6): 346-348.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.008
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Objective To evaluate regularity of bone metastasis with bone imaging in different histological types of lung cancer patients. Methods 99Tcm-methytene diphosphonate(99Tcm-MDP) whole body bone imaging was performed in 562 patients who had been diagnosed primary lung cancer. The bone imaging results of different pathological types of lung cancer were analyzed. Results Average incidence rate of bone metastasis in all types of lung cancer is 43.06%. Pulmonary adenocarcinoma and small cell carcinoma has higher incidence rate, 45.16% and 55.4% respectively. Incidence rate of bone metastasis in adenosquamous carcinoma and squamous cell carcinoma were 37.93% and 35.19% respectively, less than that of adenocarcinoma and small cell carcinoma. Conclusion The incidence rate of bone metastasis of lung cancer is higher, lung adenocarcinoma and small cell carcinoma are more susceptible to metastasis to bones.Radionuclide whole body bone imaging is the preferred method for early diagnosis of bone metastasis, and helps judge the progress of disease, select appropriate treatment programs, improve the patients live quality and prolong life expectancy.
Objective To evaluate regularity of bone metastasis with bone imaging in different histological types of lung cancer patients. Methods 99Tcm-methytene diphosphonate(99Tcm-MDP) whole body bone imaging was performed in 562 patients who had been diagnosed primary lung cancer. The bone imaging results of different pathological types of lung cancer were analyzed. Results Average incidence rate of bone metastasis in all types of lung cancer is 43.06%. Pulmonary adenocarcinoma and small cell carcinoma has higher incidence rate, 45.16% and 55.4% respectively. Incidence rate of bone metastasis in adenosquamous carcinoma and squamous cell carcinoma were 37.93% and 35.19% respectively, less than that of adenocarcinoma and small cell carcinoma. Conclusion The incidence rate of bone metastasis of lung cancer is higher, lung adenocarcinoma and small cell carcinoma are more susceptible to metastasis to bones.Radionuclide whole body bone imaging is the preferred method for early diagnosis of bone metastasis, and helps judge the progress of disease, select appropriate treatment programs, improve the patients live quality and prolong life expectancy.
2009, 33(6): 348-350.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.009
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Objective To explore the value of radionuclide venography(RNV) in the diagnosis of lower extremity deep vein thrombosis(DVT). Methods One hundred and seventy-seven patients suffering from suspected lower extremity DVT the 99Tcm-macroaggregateed albumin(99Tcm-MAA) RNV examination by SPECT.Results The sensitivity,specificity and accuracy of RNV in the diagnosis of DVT were 92.1%(1 29/140),83.7%(31/37),90.3%(160/177).DVT had a typical imaging feature of the RNV.Conclusio RNV is safe,non-invasive and simple.The sensitivity,specificity and accuracy of RNV are higher.And it can reflect the functional status of the veins of the patients with DVT more accurately.RNV is a reliable method in the diagnosis of lower extremity deep venous thrombosis.
Objective To explore the value of radionuclide venography(RNV) in the diagnosis of lower extremity deep vein thrombosis(DVT). Methods One hundred and seventy-seven patients suffering from suspected lower extremity DVT the 99Tcm-macroaggregateed albumin(99Tcm-MAA) RNV examination by SPECT.Results The sensitivity,specificity and accuracy of RNV in the diagnosis of DVT were 92.1%(1 29/140),83.7%(31/37),90.3%(160/177).DVT had a typical imaging feature of the RNV.Conclusio RNV is safe,non-invasive and simple.The sensitivity,specificity and accuracy of RNV are higher.And it can reflect the functional status of the veins of the patients with DVT more accurately.RNV is a reliable method in the diagnosis of lower extremity deep venous thrombosis.
2009, 33(6): 351-353.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.010
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Objective To compare clinical efficacy of 131I treatment for hyperthyroidism between fixed dose and calculated dose methods. Methods One hundred and forty eight patients with hyperthyroidism were randomly allocated fixed dose and calculated dose groups. Follow up was done 6 months post therapy, serum free triiodothyronine(FT3), free thyroxin(FT4) and thyroid stimulating hormone(TSH) were measured and following clinical outcome was monitored. Results The occurrence of hypothyroidism 6 months after 131I treatment in fixed dose and calculated dose groups was 31.1% and 28.4% respectively. There was no distinct difference between them(χ2=0-742, P=0.528). The cure rate was 93.3% and 85.2% respectively. There was no distinct difference between them(χ2=0.958, P=0.403). A good correlation was between clinical efficacy and thyroid mass(F=13.639, P=0.000). There was no distinct diflerence between the two groups of ages and 24 h radioactive iodine uptake(F=l.374, P=0.241; F:2.534,P=0.137). Conclusion The use of a fixed dose method simplifies the approach to treatment with potential cost savings.
Objective To compare clinical efficacy of 131I treatment for hyperthyroidism between fixed dose and calculated dose methods. Methods One hundred and forty eight patients with hyperthyroidism were randomly allocated fixed dose and calculated dose groups. Follow up was done 6 months post therapy, serum free triiodothyronine(FT3), free thyroxin(FT4) and thyroid stimulating hormone(TSH) were measured and following clinical outcome was monitored. Results The occurrence of hypothyroidism 6 months after 131I treatment in fixed dose and calculated dose groups was 31.1% and 28.4% respectively. There was no distinct difference between them(χ2=0-742, P=0.528). The cure rate was 93.3% and 85.2% respectively. There was no distinct difference between them(χ2=0.958, P=0.403). A good correlation was between clinical efficacy and thyroid mass(F=13.639, P=0.000). There was no distinct diflerence between the two groups of ages and 24 h radioactive iodine uptake(F=l.374, P=0.241; F:2.534,P=0.137). Conclusion The use of a fixed dose method simplifies the approach to treatment with potential cost savings.
2009, 33(6): 353-355.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.011
Abstract:
Objective To investigate the diagnostic significance of carbonhydrate anitigen 15-3,(CAl5-3), carcinoembryonic antigen(CEA) combined with whole body bone scan(WBS) for bone metastases in patients with breast cancer. Methods Serum levels of CA153 and CEA were measured and WBS was performed in 92 breast cancer patients. Results Serum levels of CA153 and CEA were higher in bone metastases group than in without bone metastases group significantly(CA15.3:t=91.8342; CEA:t=77.6323,P<0.01). The sensitivity and specificity of combined determinations of CA153, CEA and WBS were 95.74% and 88.89% respectively, its diagnostic efficiency was higher than any one of them. Conclusion The combined detection of CA153, CEA and WBS can improve the diagnostic efficiency of bone metastases in patient with breast cancer, especially when the results of bone scanning is equivocal.
Objective To investigate the diagnostic significance of carbonhydrate anitigen 15-3,(CAl5-3), carcinoembryonic antigen(CEA) combined with whole body bone scan(WBS) for bone metastases in patients with breast cancer. Methods Serum levels of CA153 and CEA were measured and WBS was performed in 92 breast cancer patients. Results Serum levels of CA153 and CEA were higher in bone metastases group than in without bone metastases group significantly(CA15.3:t=91.8342; CEA:t=77.6323,P<0.01). The sensitivity and specificity of combined determinations of CA153, CEA and WBS were 95.74% and 88.89% respectively, its diagnostic efficiency was higher than any one of them. Conclusion The combined detection of CA153, CEA and WBS can improve the diagnostic efficiency of bone metastases in patient with breast cancer, especially when the results of bone scanning is equivocal.
2009, 33(6): 356-358.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.012
Abstract:
Objective To evaluate the clinical significance of joint detection of urine β2-microglobulin(β2-MG),albumin(Alb) and immunoglobulin G(IgG) in patients with hyperthyroidism. Methods Urine β2-MG, Alb, IgG and serum thyroid hormone free trilute(FT3), free thyroxin(FT4) of 45 healthy volunteers(as control group) and 120 patients with hyperthyroidism were measured by radioimmunoassay(RIA). Results The urine β2-MG, Alb and IgG in the hyperthyroidism group(including the primary group(group A) and uncured group(group B) ) were distinctly higher than those in control group and hyperthyroidism cured group(group C) (t=6.682,P<0.01).It was distinctly higher in hyperthyroidism group B than that in hyperthyroidism group A(t=2.385, P<0.05). And there was no distinct difference between the control group with hyperthyroidism group C in urine prMG, Alb and IgG (t=0.568, P>0.05).There was favorable correlation between the urine β2-MG, Alb and IgG with serum FT3 and FT4(the related coefficients were 0.98, 0.88, 0.93, 0.87, 0.94, and 0.85 respectively).Conclusion It is important to measure urine β2-MG together with Alb and IgG in early judgment of the location and degree of kidney injury, as well as the severity of disease in patients with hyperthyroidism.
Objective To evaluate the clinical significance of joint detection of urine β2-microglobulin(β2-MG),albumin(Alb) and immunoglobulin G(IgG) in patients with hyperthyroidism. Methods Urine β2-MG, Alb, IgG and serum thyroid hormone free trilute(FT3), free thyroxin(FT4) of 45 healthy volunteers(as control group) and 120 patients with hyperthyroidism were measured by radioimmunoassay(RIA). Results The urine β2-MG, Alb and IgG in the hyperthyroidism group(including the primary group(group A) and uncured group(group B) ) were distinctly higher than those in control group and hyperthyroidism cured group(group C) (t=6.682,P<0.01).It was distinctly higher in hyperthyroidism group B than that in hyperthyroidism group A(t=2.385, P<0.05). And there was no distinct difference between the control group with hyperthyroidism group C in urine prMG, Alb and IgG (t=0.568, P>0.05).There was favorable correlation between the urine β2-MG, Alb and IgG with serum FT3 and FT4(the related coefficients were 0.98, 0.88, 0.93, 0.87, 0.94, and 0.85 respectively).Conclusion It is important to measure urine β2-MG together with Alb and IgG in early judgment of the location and degree of kidney injury, as well as the severity of disease in patients with hyperthyroidism.
2009, 33(6): 358-359.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.013
Abstract:
Objective To investigate the improvement of radionuclide bone imaging agent injection needle withdrawal method on whole body bone scan image quality. Methods Elbow vein injection syringe needle directly into the bone imaging agent in the routine group of 117 cases, with a cotton swab needle injection method for the rapid pull out the needle puncture point pressing, pressing moment. Improvement of 117 cases of needle injection method to put two needles into the skin swabs and blood vessels, pull out the needle while pressing two or more entry point 5min. After 2 hours underwent whole body bone SPECT imaging plane. Results The conventional group at the injection site imaging agents uptake rate was 16.24%, improved group was 2.56%. Conclusion The modified bone imaging agent injection needle withdrawal method, injection-site imaging agent uptake were significantly decreased whole body bone imaging can improve image quality.
Objective To investigate the improvement of radionuclide bone imaging agent injection needle withdrawal method on whole body bone scan image quality. Methods Elbow vein injection syringe needle directly into the bone imaging agent in the routine group of 117 cases, with a cotton swab needle injection method for the rapid pull out the needle puncture point pressing, pressing moment. Improvement of 117 cases of needle injection method to put two needles into the skin swabs and blood vessels, pull out the needle while pressing two or more entry point 5min. After 2 hours underwent whole body bone SPECT imaging plane. Results The conventional group at the injection site imaging agents uptake rate was 16.24%, improved group was 2.56%. Conclusion The modified bone imaging agent injection needle withdrawal method, injection-site imaging agent uptake were significantly decreased whole body bone imaging can improve image quality.
2009, 33(6): 360-364.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.014
Abstract:
There are more understandings on the DNA damage-induced cellular and molecular events, especially on the activation and recruitment of proteins responsible for DNA damage response and DNA damage repair to the site of damaged DNA, The activation of cell cycle checking point is more clearly elucidated on its mechanism and the subsequent cell cycle regulation.
There are more understandings on the DNA damage-induced cellular and molecular events, especially on the activation and recruitment of proteins responsible for DNA damage response and DNA damage repair to the site of damaged DNA, The activation of cell cycle checking point is more clearly elucidated on its mechanism and the subsequent cell cycle regulation.
2009, 33(6): 364-367.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.015
Abstract:
An indirect effect induced by ionizing radiation called bystander effect is being highly concentrated. Many domestic and foreign researchers have verified the existence of bystander effect and have got more understanding of the mechanism with advanced detection techniques and methods. So far, the research about it has expanded from a single cell to multiple cells, from the in vitro to the whole, and has extended to in vivo from in vitro, which provides powerful evidence to explain how bystander effects happen and the regulation mechanism and especially gives scientific evidence to clinical radiation oncology application in the future.
An indirect effect induced by ionizing radiation called bystander effect is being highly concentrated. Many domestic and foreign researchers have verified the existence of bystander effect and have got more understanding of the mechanism with advanced detection techniques and methods. So far, the research about it has expanded from a single cell to multiple cells, from the in vitro to the whole, and has extended to in vivo from in vitro, which provides powerful evidence to explain how bystander effects happen and the regulation mechanism and especially gives scientific evidence to clinical radiation oncology application in the future.
2009, 33(6): 368-371.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.016
Abstract:
Objective To discuss the iconography experience and feature of cerebral venous sinus and vein thrombosis(CVST). Methods To analyze the iconography manifestation and diagnosis feature of 28 CVST patients retrospectively. Results (1) The "cord-like" imaging, which is the typical direct sign,only can be seen in a few of CT and MRI iconography of CVST patients(3.57%).The most common indirect sign is atypical cerebral hemorrhage(50.00%) and cerebral infarction(CT:32.14%, MRI:39,29%). The most common diseased site is bilateral(75.00%).(2) Most of CT venography(CTV) or magnetic resonance angiography venography(MRV) of CVST patients show the direct sign, which include the continuity of the cerebral venous sinus was interrupted, filling defect and completely or worm-eaten-like changes(CTV:100%,MRV:83.33%), and the indirect sign, which include the thickening of the distal venous sinus and the expansion of the draining vein. Conclusions There is no significant specificity in CT and MRI imaging of CVST patients, while the CTV and MRV images show high specificity. The MRV or CTV should be executed early to confirmed diagnosis if the patient is suspected of suffering from CVST.
Objective To discuss the iconography experience and feature of cerebral venous sinus and vein thrombosis(CVST). Methods To analyze the iconography manifestation and diagnosis feature of 28 CVST patients retrospectively. Results (1) The "cord-like" imaging, which is the typical direct sign,only can be seen in a few of CT and MRI iconography of CVST patients(3.57%).The most common indirect sign is atypical cerebral hemorrhage(50.00%) and cerebral infarction(CT:32.14%, MRI:39,29%). The most common diseased site is bilateral(75.00%).(2) Most of CT venography(CTV) or magnetic resonance angiography venography(MRV) of CVST patients show the direct sign, which include the continuity of the cerebral venous sinus was interrupted, filling defect and completely or worm-eaten-like changes(CTV:100%,MRV:83.33%), and the indirect sign, which include the thickening of the distal venous sinus and the expansion of the draining vein. Conclusions There is no significant specificity in CT and MRI imaging of CVST patients, while the CTV and MRV images show high specificity. The MRV or CTV should be executed early to confirmed diagnosis if the patient is suspected of suffering from CVST.
2009, 33(6): 372-375.
doi: 10.3760/cma.j.issn.1673-4114.2009.06.017
Abstract:
Objective To study the value of MRI imaging in the diagnosis of invasive pituitary adenoma. Methods Review and analysis the MRI sign in the 32 patients of invasive pituitary adenoma comfirmed by operation and pathology. Results The following signs have been found to represent accurate criteria for invasive pituitary adenoma:①Adenoma exceeded the lateral intercarotid(ICA) line;②Cavernous sirus lateral venous compartments disappeared;③Occlusion of three or more cavernous sinus venous compartments disappeared; ④Percentage of encasement of the intracavemous ICA higher than 50% was crossed. Conclusions No trauma, no bone shadow, higher soft tissue resolution, clear anatomy background and 3D imaging act as MRI's virtue, which have became the capital examination means of preoperative diagnosis of infestation vascular tumor.
Objective To study the value of MRI imaging in the diagnosis of invasive pituitary adenoma. Methods Review and analysis the MRI sign in the 32 patients of invasive pituitary adenoma comfirmed by operation and pathology. Results The following signs have been found to represent accurate criteria for invasive pituitary adenoma:①Adenoma exceeded the lateral intercarotid(ICA) line;②Cavernous sirus lateral venous compartments disappeared;③Occlusion of three or more cavernous sinus venous compartments disappeared; ④Percentage of encasement of the intracavemous ICA higher than 50% was crossed. Conclusions No trauma, no bone shadow, higher soft tissue resolution, clear anatomy background and 3D imaging act as MRI's virtue, which have became the capital examination means of preoperative diagnosis of infestation vascular tumor.
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