Joint detection and clinical analyse of urine β₂-microglobulin,albumin and immunoglobulin G in patients with hyperthyroidism

Objective To evaluate the clinical significance of joint detection of urine β₂-microglobulin(β₂-MG),albumin(Alb) and immunoglobulin G(IgG) in patients with hyperthyroidism. Methods Urine β₂-MG, Alb, IgG and serum thyroid hormone free trilute(FT₃), free thyroxin(FT₄) of 45 healthy volunteers(as control group) and 120 patients with hyperthyroidism were measured by radioimmunoassay(RIA). Results The urine β₂-MG, Alb and IgG in the hyperthyroidism group(including the primary group(group A) and uncured group(group B) ) were distinctly higher than those in control group and hyperthyroidism cured group(group C) (t=6.682,P<0.01).It was distinctly higher in hyperthyroidism group B than that in hyperthyroidism group A(t=2.385, P<0.05). And there was no distinct difference between the control group with hyperthyroidism group C in urine prMG, Alb and IgG (t=0.568, P>0.05).There was favorable correlation between the urine β₂-MG, Alb and IgG with serum FT₃ and FT₄(the related coefficients were 0.98, 0.88, 0.93, 0.87, 0.94, and 0.85 respectively).Conclusion It is important to measure urine β₂-MG together with Alb and IgG in early judgment of the location and degree of kidney injury, as well as the severity of disease in patients with hyperthyroidism.