2009 Vol. 33, No. 3
Display Method:
2009, 33(3): 129-132.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.001
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Abstract:
As a stable isotope, 13C-breath test provide a non-invasive method to quantitatively assess organ functions. It is relatively simple to take 13C-breath test, which have good sensitivity and specificity. This review is aimed at providing advance in research of 13C-breath test and looking into the future of the art.
As a stable isotope, 13C-breath test provide a non-invasive method to quantitatively assess organ functions. It is relatively simple to take 13C-breath test, which have good sensitivity and specificity. This review is aimed at providing advance in research of 13C-breath test and looking into the future of the art.
2009, 33(3): 132-135.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.002
Abstract:
Glomerular filtration rate (GFR) is an important criterion to estimate renal function. 99Tcm-diethylenetrimainepentaacetic acid renal dynamic imaging is one of method to measure GFR that it have the characteristics of simple and accurate. But the Gate's method may be influenced by many faetors such as dose of imaging agent, outlined of regions of interest, kidney depth, and so on.
Glomerular filtration rate (GFR) is an important criterion to estimate renal function. 99Tcm-diethylenetrimainepentaacetic acid renal dynamic imaging is one of method to measure GFR that it have the characteristics of simple and accurate. But the Gate's method may be influenced by many faetors such as dose of imaging agent, outlined of regions of interest, kidney depth, and so on.
2009, 33(3): 136-139.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.003
Abstract:
Morphology imaging as a traditional method to evaluate the therapeutic effect of malignant tumor, needs to much time and can't reflect the biological changes. So it is replaced by molecular imaging method gradually. 18F-fluorodeoxyglucose (18F-FDG) PET imaging shows remarkable merit in the diagnosis, staging diagnosis and effcet monitoring of many kinds of tumor, but its specificity is low. So it can't evaluate the therapeutic effect accurately. Studies show that the prospect of 18F-fluorothymidine PET imaging is to monitor the therapeutic effect of malignant tumor, and is better than that of 18F-FDG.
Morphology imaging as a traditional method to evaluate the therapeutic effect of malignant tumor, needs to much time and can't reflect the biological changes. So it is replaced by molecular imaging method gradually. 18F-fluorodeoxyglucose (18F-FDG) PET imaging shows remarkable merit in the diagnosis, staging diagnosis and effcet monitoring of many kinds of tumor, but its specificity is low. So it can't evaluate the therapeutic effect accurately. Studies show that the prospect of 18F-fluorothymidine PET imaging is to monitor the therapeutic effect of malignant tumor, and is better than that of 18F-FDG.
2009, 33(3): 140-143.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.004
Abstract:
Gastrointestinal stromal tumor (GIST)is a mesenchymal neoplasm of uncertain malignant potential that arises predominantly in the gastrointestinal tract. Due to lack of specific physical signs, imagin g-x examination is an important auxiliary means in diagnosing gastrointestinal stromal tumor. Compared to other conventional imaging examinations, PET-CT has demonstrated unique superiority in staging, response evaluation and follow-up of gastrointestinal stromal tumor. And now it presents an overview of the application valuation of PET-CT and related imaging technology in gastrointestinal stromal tumor as follow.
Gastrointestinal stromal tumor (GIST)is a mesenchymal neoplasm of uncertain malignant potential that arises predominantly in the gastrointestinal tract. Due to lack of specific physical signs, imagin g-x examination is an important auxiliary means in diagnosing gastrointestinal stromal tumor. Compared to other conventional imaging examinations, PET-CT has demonstrated unique superiority in staging, response evaluation and follow-up of gastrointestinal stromal tumor. And now it presents an overview of the application valuation of PET-CT and related imaging technology in gastrointestinal stromal tumor as follow.
2009, 33(3): 144-148.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.005
Abstract:
99Tcm-tetrofosmin is a widely available and conveniently prepared tracer that has been shown to be a transport substrate for P-glycoprntein and multidrug resistance protein in vitro and in vivo. Its properties are similar but not identical to those of 99Tcm-sestamibi. The available data suggest that clinical studies involving imaging of muhidrug resisttanee function and in vivo modulation of muhidrug resisttance function could be performed with 99Tcm-tetrofosmin or 99Tcm-sestamibi, but the two should probably not be used interchangeably.
99Tcm-tetrofosmin is a widely available and conveniently prepared tracer that has been shown to be a transport substrate for P-glycoprntein and multidrug resistance protein in vitro and in vivo. Its properties are similar but not identical to those of 99Tcm-sestamibi. The available data suggest that clinical studies involving imaging of muhidrug resisttanee function and in vivo modulation of muhidrug resisttance function could be performed with 99Tcm-tetrofosmin or 99Tcm-sestamibi, but the two should probably not be used interchangeably.
2009, 33(3): 149-153.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.006
Abstract:
Neoadjuvant chemotherapy for breast cancer has become a trend. A series of studies for it has been carrying out. Patients receiving ineffective treatment could be switched to alternative therapies and responding patients could receive more aggressive chemotherapy. Imaging modalities were of use in detecting the efficacy of neoadjuvant therapy. In this paper, a brief overview about imaging methods be performed.
Neoadjuvant chemotherapy for breast cancer has become a trend. A series of studies for it has been carrying out. Patients receiving ineffective treatment could be switched to alternative therapies and responding patients could receive more aggressive chemotherapy. Imaging modalities were of use in detecting the efficacy of neoadjuvant therapy. In this paper, a brief overview about imaging methods be performed.
2009, 33(3): 154-158.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.007
Abstract:
Radionuclide can cause auger effect through disintegration low-energy electron (<1 keV) through electron entrapment and (or) internal conversion. Incorporation of Auger-electron emitters into the DNA have significant eytotoxicity, 125I-iododeoxyuridine (125I-UdR) is an efficient carrier inducting 125I to cell nucleolus, it is incorporated into DNA specificity only in S-phase cells. A series of studies show that 125I can absorb more likely to tumor cells, instead of the normal cell division, thus effectively splitting radiotherapy of malignant lesions. As bladder is a natural lumen, it has a unique easy perfusion and observational, 125I-UdR can kill effiently and selectively the cells of bladder tumour, reducing markedly the ratio of its recurrence of surgical treatment of patients with bladder cancer, so as to improve the survival rate. It can be used as a surgical adjuvant treatment method, is expected to be a safe, efficient and less adverse reaction the new therapies for bladder cancer treatment.
Radionuclide can cause auger effect through disintegration low-energy electron (<1 keV) through electron entrapment and (or) internal conversion. Incorporation of Auger-electron emitters into the DNA have significant eytotoxicity, 125I-iododeoxyuridine (125I-UdR) is an efficient carrier inducting 125I to cell nucleolus, it is incorporated into DNA specificity only in S-phase cells. A series of studies show that 125I can absorb more likely to tumor cells, instead of the normal cell division, thus effectively splitting radiotherapy of malignant lesions. As bladder is a natural lumen, it has a unique easy perfusion and observational, 125I-UdR can kill effiently and selectively the cells of bladder tumour, reducing markedly the ratio of its recurrence of surgical treatment of patients with bladder cancer, so as to improve the survival rate. It can be used as a surgical adjuvant treatment method, is expected to be a safe, efficient and less adverse reaction the new therapies for bladder cancer treatment.
2009, 33(3): 159-163.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.008
Abstract:
Radiofrequency ablation (RFA)is an advanced, minimally invasive technique in the treatment of patients with lung cancer and has been found to be both safe and technically feasible with a high local efficacy, but for he size of the lesion is over 3.0 cm diameter there is less effective. Iodine-131-labeled nuclei of tumor cells chimeric monoclonal antibody, a novel radioimmunotherapy provided a new therapeutic approaches for lung cancer, but the complete response is low. For RFA can induce a mass complete tumor necrosis which greatly increase the targeting area for radioimmunotherapy, thus RFA followed by 131I-nuclei of tumor cells chimeric monoclonal antibody adjuvant treatment may apparently improve the therapeutic efficacy of lung cancer, especially for tumors larger than 3.0 cm diameter.
Radiofrequency ablation (RFA)is an advanced, minimally invasive technique in the treatment of patients with lung cancer and has been found to be both safe and technically feasible with a high local efficacy, but for he size of the lesion is over 3.0 cm diameter there is less effective. Iodine-131-labeled nuclei of tumor cells chimeric monoclonal antibody, a novel radioimmunotherapy provided a new therapeutic approaches for lung cancer, but the complete response is low. For RFA can induce a mass complete tumor necrosis which greatly increase the targeting area for radioimmunotherapy, thus RFA followed by 131I-nuclei of tumor cells chimeric monoclonal antibody adjuvant treatment may apparently improve the therapeutic efficacy of lung cancer, especially for tumors larger than 3.0 cm diameter.
2009, 33(3): 163-167.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.009
Abstract:
The systemic treatment of differentiated thyroid carcinoma include thyroidectomy, radioactive iodine and thyroxine suppression of thyroid-stimulating hormone. The effectivity of the iodine-131 therepy were well accepted, but still some of issues were still debatable.
The systemic treatment of differentiated thyroid carcinoma include thyroidectomy, radioactive iodine and thyroxine suppression of thyroid-stimulating hormone. The effectivity of the iodine-131 therepy were well accepted, but still some of issues were still debatable.
2009, 33(3): 167-170.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.010
Abstract:
Thyroid cancer account approximately 1.3%-1.5% of cancers all over the body, the attack rate is raising up recently. Most operation is subtotal thyroidectomy at the first time, because thyroid cancer was regarded as thyroid nodule usually account 90.5%. Operation one more time with leftover cancer rate about 41.3%, and with lymphonodi cervicales deadexis about 72.8%. Most patient reluctancy operation again in view of complication with hypoparathyroidism and injure of recurrent nerve. The efficacy of radioiodine ablation can eliminate the minimum cancer which concealed in remained thyroid glandular tissue, and cut down the recurrence rate of thyroid cancer, and destroy metastasis, in favour of long-term follow-up. A great quantity of literature report about 60% with 1.11GBq 131I and 90% with retreatment with 1.11GBq 131I in patients with differentiated thyroid cancer undergoing subtotal thyroidectomy.131I treatment can shorten length of stay, and decrease radiation effect, and cut down side effect and economy burden, as far as possible to achieve therapeutic efficacy.
Thyroid cancer account approximately 1.3%-1.5% of cancers all over the body, the attack rate is raising up recently. Most operation is subtotal thyroidectomy at the first time, because thyroid cancer was regarded as thyroid nodule usually account 90.5%. Operation one more time with leftover cancer rate about 41.3%, and with lymphonodi cervicales deadexis about 72.8%. Most patient reluctancy operation again in view of complication with hypoparathyroidism and injure of recurrent nerve. The efficacy of radioiodine ablation can eliminate the minimum cancer which concealed in remained thyroid glandular tissue, and cut down the recurrence rate of thyroid cancer, and destroy metastasis, in favour of long-term follow-up. A great quantity of literature report about 60% with 1.11GBq 131I and 90% with retreatment with 1.11GBq 131I in patients with differentiated thyroid cancer undergoing subtotal thyroidectomy.131I treatment can shorten length of stay, and decrease radiation effect, and cut down side effect and economy burden, as far as possible to achieve therapeutic efficacy.
2009, 33(3): 171-174,183.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.011
Abstract:
Hyperthyroidism in adolescents and children is a common endocrinium disorder, which disturbs the development of diverse body systems, especially of skeletal and central nervous systems. The patients with hyperthyroidism have a lower long-term, spontaneous remission of the disease. The majority of adolescents and children patients with hyperthyroidism have to receive an effective, safe therapy. Currently, there are three methods for treating hyperthyroidism. They include in antithyroid drugs (ATD), surgery and radioactive iodine (131I) therapy. ATD always is the first line way to these patients with hyperthyroidism for endocrinologist yet. But the remission rate of hyperthyroidism for ATD is lower, the remission of hyperthyroidism also need spend longer time, and side effects of ATD are more common in adolescents and children than in adult. The success ratio and complications of surgery are mainly depended on the technic of surgeons, 131I has been used as the treatment of hyperthyroidism for more than six decades. So far, there are still no enough evidences to show that the incidence of thyroid cancer and other malignant diseases, the patients' fertility rate, rate of abortion and malformation of descendants in hyperthyroidism patients following 131I were marked difference with that in other people. The remission rate of hyperthyroidism following 131I was higher and its side effects were less. 131I therapy can be the first choice to adolescents and children with hyperthyroidism who are no suitable to ATD therapy. Hypothyroidism is most often one outcome of pediatric patients with hyperthyroidism after 131I therapy. Hence, the patients with hypothyroidism have to receive the replacement treatment of thyroxine. Since the development of adolescents and children are more dependent on thyroxine and adolescents and children are more sensitive to the radioactive rays than adults, it is more suitable to get ideal control with a relative lower dosage of 131I to adolescents and children with hyperthyroidism.
Hyperthyroidism in adolescents and children is a common endocrinium disorder, which disturbs the development of diverse body systems, especially of skeletal and central nervous systems. The patients with hyperthyroidism have a lower long-term, spontaneous remission of the disease. The majority of adolescents and children patients with hyperthyroidism have to receive an effective, safe therapy. Currently, there are three methods for treating hyperthyroidism. They include in antithyroid drugs (ATD), surgery and radioactive iodine (131I) therapy. ATD always is the first line way to these patients with hyperthyroidism for endocrinologist yet. But the remission rate of hyperthyroidism for ATD is lower, the remission of hyperthyroidism also need spend longer time, and side effects of ATD are more common in adolescents and children than in adult. The success ratio and complications of surgery are mainly depended on the technic of surgeons, 131I has been used as the treatment of hyperthyroidism for more than six decades. So far, there are still no enough evidences to show that the incidence of thyroid cancer and other malignant diseases, the patients' fertility rate, rate of abortion and malformation of descendants in hyperthyroidism patients following 131I were marked difference with that in other people. The remission rate of hyperthyroidism following 131I was higher and its side effects were less. 131I therapy can be the first choice to adolescents and children with hyperthyroidism who are no suitable to ATD therapy. Hypothyroidism is most often one outcome of pediatric patients with hyperthyroidism after 131I therapy. Hence, the patients with hypothyroidism have to receive the replacement treatment of thyroxine. Since the development of adolescents and children are more dependent on thyroxine and adolescents and children are more sensitive to the radioactive rays than adults, it is more suitable to get ideal control with a relative lower dosage of 131I to adolescents and children with hyperthyroidism.
2009, 33(3): 175-178.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.012
Abstract:
Hyperthyroidism is a frequently-occurring endocrine disease. Aantithyroid drugs, surgery and radioactive iodine therapy are currently accepted and effective methods of treatment for hyperthyroidism. Years of clinical practices and a lot of researches on each of the three treatment methods to further deepen the understanding of the characteristics, the choice of treatment for hyperthyroidism tend to have a new change. After comparing and evaluating the three treatments for hyperthyroidism, most scholars believe that radioactive iodine therapy to treat hyperthyroidism will maintain its unique position before the physiological treatment for hyperthyroidism is uncertainly discoveried in the future.
Hyperthyroidism is a frequently-occurring endocrine disease. Aantithyroid drugs, surgery and radioactive iodine therapy are currently accepted and effective methods of treatment for hyperthyroidism. Years of clinical practices and a lot of researches on each of the three treatment methods to further deepen the understanding of the characteristics, the choice of treatment for hyperthyroidism tend to have a new change. After comparing and evaluating the three treatments for hyperthyroidism, most scholars believe that radioactive iodine therapy to treat hyperthyroidism will maintain its unique position before the physiological treatment for hyperthyroidism is uncertainly discoveried in the future.
2009, 33(3): 184-186,192.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.017
Abstract:
Objective To study radiation dose effect on three primary colors color value in trac, id brilliant red B solution. Methods Prepare aqueous solution with different eoneentration traeid brilliant red B, irradiated by 0-2000 Gy 60Coγ-ray. Get data from the solution by special instrument which can detect three primary eolors information. Analyze, manipulate, draw eurves for the experiment result. Further preserve the irradiated sample four weeks in room temperature environment and repeat the prnc, ess above. Results The experiment result show three primary colors color value in the aqueous solutions changes by difterent doses 60Coγ-ray. The red color value are gradually decreasing as the radiation dose is adding, the grecn color value are gradually increasing at the same time. The red and grecn color value ehanges evidently and trends adversely. The blue color value little changed. The experimental results have little changes after the irradiated samples preserve four weeks in room temperature environment. Conclusions The experiment demonstrate that radiation dose can be studied based on three primary colors color value, may be it will have more study subject by this methods.
Objective To study radiation dose effect on three primary colors color value in trac, id brilliant red B solution. Methods Prepare aqueous solution with different eoneentration traeid brilliant red B, irradiated by 0-2000 Gy 60Coγ-ray. Get data from the solution by special instrument which can detect three primary eolors information. Analyze, manipulate, draw eurves for the experiment result. Further preserve the irradiated sample four weeks in room temperature environment and repeat the prnc, ess above. Results The experiment result show three primary colors color value in the aqueous solutions changes by difterent doses 60Coγ-ray. The red color value are gradually decreasing as the radiation dose is adding, the grecn color value are gradually increasing at the same time. The red and grecn color value ehanges evidently and trends adversely. The blue color value little changed. The experimental results have little changes after the irradiated samples preserve four weeks in room temperature environment. Conclusions The experiment demonstrate that radiation dose can be studied based on three primary colors color value, may be it will have more study subject by this methods.
2009, 33(3): 187-189.
doi: 10.3760/cma.j.issn.1673-4114.2009.03.018
Abstract:
Radiation dermatitis is often seen and is often a complication of radiation therapy of tumors. It is characterized by poor healing, stubborn relapse, and carcinogenesis. The treatment include drug, physical therapy and surgery. This article describes the treatment progress of radiation dermatitis from external exposure.
Radiation dermatitis is often seen and is often a complication of radiation therapy of tumors. It is characterized by poor healing, stubborn relapse, and carcinogenesis. The treatment include drug, physical therapy and surgery. This article describes the treatment progress of radiation dermatitis from external exposure.
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