Experimental and clinical treatment of bladder cancer with ¹²⁵I-iododeoxyuridine

Radionuclide can cause auger effect through disintegration low-energy electron (<1 keV) through electron entrapment and (or) internal conversion. Incorporation of Auger-electron emitters into the DNA have significant eytotoxicity, ¹²⁵I-iododeoxyuridine (¹²⁵I-UdR) is an efficient carrier inducting ¹²⁵I to cell nucleolus, it is incorporated into DNA specificity only in S-phase cells. A series of studies show that ¹²⁵I can absorb more likely to tumor cells, instead of the normal cell division, thus effectively splitting radiotherapy of malignant lesions. As bladder is a natural lumen, it has a unique easy perfusion and observational, ¹²⁵I-UdR can kill effiently and selectively the cells of bladder tumour, reducing markedly the ratio of its recurrence of surgical treatment of patients with bladder cancer, so as to improve the survival rate. It can be used as a surgical adjuvant treatment method, is expected to be a safe, efficient and less adverse reaction the new therapies for bladder cancer treatment.