2005 Vol. 29, No. 1
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2005, 29(1): 1-5.
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Abstract:
Nowadays, the study on the plasticity of the brain is one of the hotspots in nerve scientific research. PET and fMRI provided powerful weapon to study brain plasticity, but some metholody can conflict the brain function study. The review elucide the the metholody questions from the choice of pantiets and control, defining motor recovery, the choice of motor task, the effect of brain morphological, interpreting changes in activation and analysis methods of PET images.
Nowadays, the study on the plasticity of the brain is one of the hotspots in nerve scientific research. PET and fMRI provided powerful weapon to study brain plasticity, but some metholody can conflict the brain function study. The review elucide the the metholody questions from the choice of pantiets and control, defining motor recovery, the choice of motor task, the effect of brain morphological, interpreting changes in activation and analysis methods of PET images.
2005, 29(1): 6-9.
Abstract:
The standardized uptake value (SUV) and the ratio of lesion's counts to background counts (L/B) are usually used in clinical oncology. L/B is mostly used for dual-head coincidence detection system. SUV is widely used for dedicated PET in differentiating the benign and the malignant, tumor staging, evalu-ating therapy response and predicting patient survival and disease-free interval. And some factors which should be paid attention to in clinical application are presented.
The standardized uptake value (SUV) and the ratio of lesion's counts to background counts (L/B) are usually used in clinical oncology. L/B is mostly used for dual-head coincidence detection system. SUV is widely used for dedicated PET in differentiating the benign and the malignant, tumor staging, evalu-ating therapy response and predicting patient survival and disease-free interval. And some factors which should be paid attention to in clinical application are presented.
2005, 29(1): 10-14.
Abstract:
Energy metabolism and amino acid transport and incorporation are important components of the pathophysiology of brain tumors. Combination of 18F-FDG and amino acid, especially 11C-MET is more useful than single tracer in the field of brain tumor grading, differential diagnosis recurrent tumor from radiation necrosis and evaluation of prognosis. In addition, 11C-MET is better than 18F-FDG in delineating tumor boundary, so it can provides more exact information in biopsy localization and planning of radiosurgery.
Energy metabolism and amino acid transport and incorporation are important components of the pathophysiology of brain tumors. Combination of 18F-FDG and amino acid, especially 11C-MET is more useful than single tracer in the field of brain tumor grading, differential diagnosis recurrent tumor from radiation necrosis and evaluation of prognosis. In addition, 11C-MET is better than 18F-FDG in delineating tumor boundary, so it can provides more exact information in biopsy localization and planning of radiosurgery.
2005, 29(1): 15-18.
Abstract:
When protein, nucleic acid, polypeptide and antibody labeled with 99Tcm, bifunctional chelating agents(BFCA)are commonly used in order to avoid damages by directly labeling. We choose two BFCA:NHS-MAG3 and HYNIC as representation. The synthesis of these two BFCA is clear and the meth-ods of conjugating and labeling are mature. Through BFCA we can gain high radiolabeling yield, radiochemi-cal purity and specific activity. The usage of BFCA can provide necessary condition for molecular imaging and extensively clinical foreground.
When protein, nucleic acid, polypeptide and antibody labeled with 99Tcm, bifunctional chelating agents(BFCA)are commonly used in order to avoid damages by directly labeling. We choose two BFCA:NHS-MAG3 and HYNIC as representation. The synthesis of these two BFCA is clear and the meth-ods of conjugating and labeling are mature. Through BFCA we can gain high radiolabeling yield, radiochemi-cal purity and specific activity. The usage of BFCA can provide necessary condition for molecular imaging and extensively clinical foreground.
2005, 29(1): 19-22.
Abstract:
Tcm labeled isonitrile complexes is the most widely used myocardial perfusion imaging agents, and it is also used to diagnose tumors. This review gives a sum up of the development, classifica-tion and application of 99Tcm labeled isonitrile complexes, and the synthesis methods of isonitrile ligands and labeled complexes are given.
Tcm labeled isonitrile complexes is the most widely used myocardial perfusion imaging agents, and it is also used to diagnose tumors. This review gives a sum up of the development, classifica-tion and application of 99Tcm labeled isonitrile complexes, and the synthesis methods of isonitrile ligands and labeled complexes are given.
2005, 29(1): 23-26.
Abstract:
Phosphatidyl serine exposures on the outer leaflet of the plasma membrane lipid bilayer at the beginning of apoptosis, 99Tcm-labeled Annexin V is used to image in vivo the phosphatidyl serine that explode on the outer surface of cell membrane after apoptosis so that apoptosis can be detected on the early stage.
Phosphatidyl serine exposures on the outer leaflet of the plasma membrane lipid bilayer at the beginning of apoptosis, 99Tcm-labeled Annexin V is used to image in vivo the phosphatidyl serine that explode on the outer surface of cell membrane after apoptosis so that apoptosis can be detected on the early stage.
2005, 29(1): 27-29.
Abstract:
Parkinson's disease(PD) is a kind of degenerative disease afflicting middle-aged and older people, accompanied by abnormal D2 receptor function resulted from dopamine deficiency. Raclopride is an ideal tracer because of its high selectivity and affinity to D2 receptor. 11C-raclopride PET can directly show the distribution and density of D2 receptor on molecular level that it's of great importance in the analysis of the illness state and dopamine mechanism of sequential movement, movement-fluctuation complication, medicine and surgical therapy.
Parkinson's disease(PD) is a kind of degenerative disease afflicting middle-aged and older people, accompanied by abnormal D2 receptor function resulted from dopamine deficiency. Raclopride is an ideal tracer because of its high selectivity and affinity to D2 receptor. 11C-raclopride PET can directly show the distribution and density of D2 receptor on molecular level that it's of great importance in the analysis of the illness state and dopamine mechanism of sequential movement, movement-fluctuation complication, medicine and surgical therapy.
2005, 29(1): 30-32.
Abstract:
Combined radiation and wound injury (CRWI) often occurs under the conditions of nuclear explosions, severe nuclear accidents, radiological terrorism and radiotherapy accidents. A prominent medical problem is that this kind of skin wound is very complex and difficult to heal. The quantity and function damage of cellular components in the wound sites including hematopoietic cells and repairing cells plays key roles in the healing delay process. For the treatment of CRWI, promoting wound healing and the hematopoietic recovery should be considered simultaneously. Several chemical or natural drugs and growth factors have shown promoting effects on the wound healing in CRWI. Application of adult multipotent stem cells may provide a new promising way for the management of CRWI.
Combined radiation and wound injury (CRWI) often occurs under the conditions of nuclear explosions, severe nuclear accidents, radiological terrorism and radiotherapy accidents. A prominent medical problem is that this kind of skin wound is very complex and difficult to heal. The quantity and function damage of cellular components in the wound sites including hematopoietic cells and repairing cells plays key roles in the healing delay process. For the treatment of CRWI, promoting wound healing and the hematopoietic recovery should be considered simultaneously. Several chemical or natural drugs and growth factors have shown promoting effects on the wound healing in CRWI. Application of adult multipotent stem cells may provide a new promising way for the management of CRWI.
2005, 29(1): 33-36.
Abstract:
Irradiation burn is common complication during radiotherapy and the healing critically depends on angiogenesis, as a result, regulation of angiogenesis is always regarded as a focus in research. Studies have indicated that vascular endothelial growth factor(VEGF)is probably a key factor controlling angiogenesis and wound healing, which illustrated a new therapy in irradiation injure.
Irradiation burn is common complication during radiotherapy and the healing critically depends on angiogenesis, as a result, regulation of angiogenesis is always regarded as a focus in research. Studies have indicated that vascular endothelial growth factor(VEGF)is probably a key factor controlling angiogenesis and wound healing, which illustrated a new therapy in irradiation injure.
2005, 29(1): 37-40.
Abstract:
Radiation injury of blood vessels has become one of most important research field with the development of stereotactic conformal radiotherapy technique. But there were not adequate research in this field. In this article, the acute lesions and delayed lesions of radiation injury, coronary artery disease of radiation, and experimental radiation-induced vascular disease were discussed. Clarifying the research status, definitude the research direction, and assisting the clinic at a certain extent were the aim of this article.
Radiation injury of blood vessels has become one of most important research field with the development of stereotactic conformal radiotherapy technique. But there were not adequate research in this field. In this article, the acute lesions and delayed lesions of radiation injury, coronary artery disease of radiation, and experimental radiation-induced vascular disease were discussed. Clarifying the research status, definitude the research direction, and assisting the clinic at a certain extent were the aim of this article.
2005, 29(1): 40-43.
Abstract:
s The post operation therapy on the malignant cerebral glioma is a key to the life extension of a patient. It is a hotspot in radiobiology of tumor and radiotherapy to study how to enhance the radiosensitivity of the tumor tissues and increase the radioresistance of the normal tissues. It was found that activation of PI3K/Akt pathway, an anti-apoptosis pathway, may result in enhancement of radioresistance of some cell lines. Particularly, in researches of ultraviolet (UV) radiation on epidermic cells. It was found that the reactive oxygen species(ROS) induced by UV may be one of the causes to activate the PI3K/Akt. Induction of relative cytokines by ionizing radiation may mediate radioresistance of glioma through PI3K/Akt. It was also found that PI3K and relative kinase may enhance radioresistance of cells through DNA repair. In a word, researches of PI3K/Akt pathway may provide some new radiosensitizers for radiotherapy of glioma.
s The post operation therapy on the malignant cerebral glioma is a key to the life extension of a patient. It is a hotspot in radiobiology of tumor and radiotherapy to study how to enhance the radiosensitivity of the tumor tissues and increase the radioresistance of the normal tissues. It was found that activation of PI3K/Akt pathway, an anti-apoptosis pathway, may result in enhancement of radioresistance of some cell lines. Particularly, in researches of ultraviolet (UV) radiation on epidermic cells. It was found that the reactive oxygen species(ROS) induced by UV may be one of the causes to activate the PI3K/Akt. Induction of relative cytokines by ionizing radiation may mediate radioresistance of glioma through PI3K/Akt. It was also found that PI3K and relative kinase may enhance radioresistance of cells through DNA repair. In a word, researches of PI3K/Akt pathway may provide some new radiosensitizers for radiotherapy of glioma.
2005, 29(1): 44-47.
Abstract:
Sphingomyelinase can hydrolyze the sphingomyelin to ceramide. And sphingomyelinase play important roles in diverse physiological. Acid sphingomyelinase is the most important type of sphin-gomyelinase.
Sphingomyelinase can hydrolyze the sphingomyelin to ceramide. And sphingomyelinase play important roles in diverse physiological. Acid sphingomyelinase is the most important type of sphin-gomyelinase.
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