PI3K/Akt and radioresistance of glioma

s The post operation therapy on the malignant cerebral glioma is a key to the life extension of a patient. It is a hotspot in radiobiology of tumor and radiotherapy to study how to enhance the radiosensitivity of the tumor tissues and increase the radioresistance of the normal tissues. It was found that activation of PI3K/Akt pathway, an anti-apoptosis pathway, may result in enhancement of radioresistance of some cell lines. Particularly, in researches of ultraviolet (UV) radiation on epidermic cells. It was found that the reactive oxygen species(ROS) induced by UV may be one of the causes to activate the PI3K/Akt. Induction of relative cytokines by ionizing radiation may mediate radioresistance of glioma through PI3K/Akt. It was also found that PI3K and relative kinase may enhance radioresistance of cells through DNA repair. In a word, researches of PI3K/Akt pathway may provide some new radiosensitizers for radiotherapy of glioma.