2001 Vol. 25, No. 3
Display Method:
2001, 25(3): 97-100.
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Abstract:
With the rapid development of molecular nuclear medicine, N-hydroxysuccinimidyl S-acetylmercap-toacetyltriglycline (NHS-MAG3) as one effective bifunctional chelator has been used to radiolabel proteins, small peptides and DNA oligonucleotides with 99Tcm. The lable by the MAG3-labeling method show high labeling efficiencies and high specific activities and hold desirable stability in vitro and in vivo. The binding of the lable with plasma protein is low. So many potentially useful radioparmaceuticals for diagnosis and therapy may be produced via the NHS-MAG3 method.
With the rapid development of molecular nuclear medicine, N-hydroxysuccinimidyl S-acetylmercap-toacetyltriglycline (NHS-MAG3) as one effective bifunctional chelator has been used to radiolabel proteins, small peptides and DNA oligonucleotides with 99Tcm. The lable by the MAG3-labeling method show high labeling efficiencies and high specific activities and hold desirable stability in vitro and in vivo. The binding of the lable with plasma protein is low. So many potentially useful radioparmaceuticals for diagnosis and therapy may be produced via the NHS-MAG3 method.
2001, 25(3): 100-103.
Abstract:
99Tcm-TRODAT-1 is a novel technetium-99m complex as a dopamine transporter imaging agent.The imaging of SPECT with it will have an important value in the early diagnosis of Parkinson's disease. This article reviews the progress of this promising agent.
99Tcm-TRODAT-1 is a novel technetium-99m complex as a dopamine transporter imaging agent.The imaging of SPECT with it will have an important value in the early diagnosis of Parkinson's disease. This article reviews the progress of this promising agent.
2001, 25(3): 103-106.
Abstract:
Bis [N-ethoxy, N-ethyl (dithiocarbamato)] nitrido Tc (V) (99Tcm-N-NOET) is a neutral lipophilic tech-netium agent of myocardial perfusion presenting the high first-pass myocardial uptake and long myocardial retention. The location of 99Tcm-N-NOET myocardial uptake is on cell membranes, and its myocardial uptake is not en-ergy-dependent, which is affected by L-type calcium channel inhibitor.99Tcm-N-NOET not only has a myocardial redistribution equivalent to 201Tl, the sensitivity and specificity of its myocardial perfusion imaging in detecting coronary artery disease but also are similar to 201Tl.
Bis [N-ethoxy, N-ethyl (dithiocarbamato)] nitrido Tc (V) (99Tcm-N-NOET) is a neutral lipophilic tech-netium agent of myocardial perfusion presenting the high first-pass myocardial uptake and long myocardial retention. The location of 99Tcm-N-NOET myocardial uptake is on cell membranes, and its myocardial uptake is not en-ergy-dependent, which is affected by L-type calcium channel inhibitor.99Tcm-N-NOET not only has a myocardial redistribution equivalent to 201Tl, the sensitivity and specificity of its myocardial perfusion imaging in detecting coronary artery disease but also are similar to 201Tl.
2001, 25(3): 107-111.
Abstract:
Image fusion is a research focus of medicalimage processing. Proper registrations were desired in clinical diagnoses and therapy to obtain complementary information from multi-modality images. Three key techniques,transformation, matching and information acquirement, were introduced. Different regular matching methods, es-pecially various algorithms of intrinsic method, were overviewed and compared. The development trend of regis-tration was also previewed.
Image fusion is a research focus of medicalimage processing. Proper registrations were desired in clinical diagnoses and therapy to obtain complementary information from multi-modality images. Three key techniques,transformation, matching and information acquirement, were introduced. Different regular matching methods, es-pecially various algorithms of intrinsic method, were overviewed and compared. The development trend of regis-tration was also previewed.
2001, 25(3): 111-114.
Abstract:
Thyrotropin receptor antibodies (T RAb) are not homogeneous, which are composed by four antibodies at least. TRAb plays very important roles in autoimmune thyroid diseases and off-thyroid symptoms associated, and other thyroiditis in clinical diagnosis, assessment of curative effects, determination of the time to stop medicine,prognostication of recurrence and inspection of high risk population.
Thyrotropin receptor antibodies (T RAb) are not homogeneous, which are composed by four antibodies at least. TRAb plays very important roles in autoimmune thyroid diseases and off-thyroid symptoms associated, and other thyroiditis in clinical diagnosis, assessment of curative effects, determination of the time to stop medicine,prognostication of recurrence and inspection of high risk population.
2001, 25(3): 115-120.
Abstract:
Grown-up brain imaging is one of the very important measures for diagnosing in clinic nuclear medicine.The patients will receive different absorb doses when they have different illness or diagnosed by different measures and different reagents. Obstructing absorbability, promoting excretion, substitution and perfect quality assuring sys-tem are necessary measures to reduce patient's absorb doses and risks caused by isotopes diagnoses.
Grown-up brain imaging is one of the very important measures for diagnosing in clinic nuclear medicine.The patients will receive different absorb doses when they have different illness or diagnosed by different measures and different reagents. Obstructing absorbability, promoting excretion, substitution and perfect quality assuring sys-tem are necessary measures to reduce patient's absorb doses and risks caused by isotopes diagnoses.
2001, 25(3): 120-122141.
Abstract:
The coincidence technique employed in positron emission tomography (PET) to detect the two simultaneously, emitted annihilation photons of 511 keV that travel at a 180�angle to each other. Because of the scattered radiation, the scattered photons were also detected by the coincidence technique in PET. PET images uncorrected for scatter give inaccurate image data and, in addition, the scatter contribution could give rise to signal to noise ratio (SN R) and could produce highly structured errors or artifacts in the images. So, to understand of the effects of the scatter on PET imaging, and to master the measured and corrected methods of the scatter will improve the quality of image and accurately measure the biological parameters of the radiophamaceutical in vivo.
The coincidence technique employed in positron emission tomography (PET) to detect the two simultaneously, emitted annihilation photons of 511 keV that travel at a 180�angle to each other. Because of the scattered radiation, the scattered photons were also detected by the coincidence technique in PET. PET images uncorrected for scatter give inaccurate image data and, in addition, the scatter contribution could give rise to signal to noise ratio (SN R) and could produce highly structured errors or artifacts in the images. So, to understand of the effects of the scatter on PET imaging, and to master the measured and corrected methods of the scatter will improve the quality of image and accurately measure the biological parameters of the radiophamaceutical in vivo.
2001, 25(3): 127-130.
Abstract:
The late onset of necrosis and fibrosis in normal tissoes can be a serious conseqaence of radiotherapy.Lenkocyte infiltration is commonly observed at sites of irradiation and is likely to play an important role in this pathogenesis. This review is focused on the role of adhesion molecules in radiation-tnduced leukocyte infiltration and the therapeutic implications.
The late onset of necrosis and fibrosis in normal tissoes can be a serious conseqaence of radiotherapy.Lenkocyte infiltration is commonly observed at sites of irradiation and is likely to play an important role in this pathogenesis. This review is focused on the role of adhesion molecules in radiation-tnduced leukocyte infiltration and the therapeutic implications.
2001, 25(3): 130-134.
Abstract:
Radiation increases adhesion of leukocytes to irradiated vascular endothelial cells in vivo andvitro during early stage and this correlation with nomal tissues reaction and injuries caused by irradiation. The probable mechanisms are up-regulated expression of some adhesive molecules induced by ionizing radiation, nuclear factor NF-κB adjust the expression of this adhesive molecules, correspondent antagonist could decreases or eliminates this effection.
Radiation increases adhesion of leukocytes to irradiated vascular endothelial cells in vivo andvitro during early stage and this correlation with nomal tissues reaction and injuries caused by irradiation. The probable mechanisms are up-regulated expression of some adhesive molecules induced by ionizing radiation, nuclear factor NF-κB adjust the expression of this adhesive molecules, correspondent antagonist could decreases or eliminates this effection.
2001, 25(3): 134-137.
Abstract:
The paper introduces biological dose reconstruction methodology of the early exposuer and studies on dose response curve in vitro by FISH in recent years and comments the possibility of the technical application to victims'dose verification and reconstruction in abroad. FISH will become a new approach to analyze chromosome aberration and dose reconstruction for early exposure.
The paper introduces biological dose reconstruction methodology of the early exposuer and studies on dose response curve in vitro by FISH in recent years and comments the possibility of the technical application to victims'dose verification and reconstruction in abroad. FISH will become a new approach to analyze chromosome aberration and dose reconstruction for early exposure.
2001, 25(3): 138-141.
Abstract:
Gene therapy is an exciting frontier in medicine today. Radiologist will make an uniquely contribution to these exciting new technologies at every level by choosing sites for targeting therapy, perfecting and establishing routes of delivery, developing imaging strategies to monitor therapy and assess gene expression, developing radio-therapeutic used of gene therapy.
Gene therapy is an exciting frontier in medicine today. Radiologist will make an uniquely contribution to these exciting new technologies at every level by choosing sites for targeting therapy, perfecting and establishing routes of delivery, developing imaging strategies to monitor therapy and assess gene expression, developing radio-therapeutic used of gene therapy.
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