Progressive study of adhesion molecules in normal tissue injury induced by irradiation

The late onset of necrosis and fibrosis in normal tissoes can be a serious conseqaence of radiotherapy.Lenkocyte infiltration is commonly observed at sites of irradiation and is likely to play an important role in this pathogenesis. This review is focused on the role of adhesion molecules in radiation-tnduced leukocyte infiltration and the therapeutic implications.