Effection in leukocytes adhesion to irradiated vascular endothelial cells induced by ionizing radiation

Radiation increases adhesion of leukocytes to irradiated vascular endothelial cells in vivo andvitro during early stage and this correlation with nomal tissues reaction and injuries caused by irradiation. The probable mechanisms are up-regulated expression of some adhesive molecules induced by ionizing radiation, nuclear factor NF-κB adjust the expression of this adhesive molecules, correspondent antagonist could decreases or eliminates this effection.