2000 Vol. 24, No. 2
Display Method:
2000, 24(2): 49-51.
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Abstract:
Recent studies indicate that sigma receptors are a class of non-opiate, non-dopaminergic proteins. The structure, physiological and biochemical functions, and the pharmacological significance of sigma receptors are not completely understood. A wide variety of human tumors, including malignant melanoma, non-small cell lung carcinoma,tumors of breast, prostate, colon, kidney, and neural origin contain a high density of sigma receptors. Therefore, the development of high affinity sigma receptor-specific radio-ligands has become an attractive target.The radio-ligands not only can be used to study the physiological and biochemical functions and pharmacology of sigma receptors, but also can be potentially used to image and treat sigma receptor-positive tumors.
Recent studies indicate that sigma receptors are a class of non-opiate, non-dopaminergic proteins. The structure, physiological and biochemical functions, and the pharmacological significance of sigma receptors are not completely understood. A wide variety of human tumors, including malignant melanoma, non-small cell lung carcinoma,tumors of breast, prostate, colon, kidney, and neural origin contain a high density of sigma receptors. Therefore, the development of high affinity sigma receptor-specific radio-ligands has become an attractive target.The radio-ligands not only can be used to study the physiological and biochemical functions and pharmacology of sigma receptors, but also can be potentially used to image and treat sigma receptor-positive tumors.
2000, 24(2): 51-54.
Abstract:
Phosphatidylserine exposures on the outer leaflet of the plasma membrane lipid bilayer at the beginning of apoptosis. 99Tcm-labeled annexin V can be used to image apoptosis in vivo according to annexin V has a high affinity with PS.
Phosphatidylserine exposures on the outer leaflet of the plasma membrane lipid bilayer at the beginning of apoptosis. 99Tcm-labeled annexin V can be used to image apoptosis in vivo according to annexin V has a high affinity with PS.
2000, 24(2): 55-58.
Abstract:
The energy substrate environment in body (the level of plasmaglucose and free fat acid et al) during the 18F-FDG imaging significantly affects the uptake of 18F-FDG in the tissues of tumor, myocardium and brain. It will further influence the quality of image, the clinical analysis of the image and the clinical judgement based on the 18F-FDG imaging. So during the 18F-FDG study,reasonably controlling of energy substrate environment according to the clinical study purpose is the basis of improving the quality of image and making correct analysis of the image.
The energy substrate environment in body (the level of plasmaglucose and free fat acid et al) during the 18F-FDG imaging significantly affects the uptake of 18F-FDG in the tissues of tumor, myocardium and brain. It will further influence the quality of image, the clinical analysis of the image and the clinical judgement based on the 18F-FDG imaging. So during the 18F-FDG study,reasonably controlling of energy substrate environment according to the clinical study purpose is the basis of improving the quality of image and making correct analysis of the image.
2000, 24(2): 59-62.
Abstract:
In recent years, the neurotransmitter mapping has been rapidly developed from a lot of fundamental researches to the studies of clinical applications. At present, the dopaminergic neurotransmitter and receptor imaging in the central neurotransmitter mapping study are the most active area including dopaminergic receptor, dopaminergic neurotransmitter and dopaminergic transporter imaging, etc,. The nuclear medicine functional imaging technique with positron emission tomography and single photon emission computed tomography possesses potential advantages in the diagnosis and distinguished diagnosis of neuropsychiatric disorders and movement disorders, and in the study of recognition function.
In recent years, the neurotransmitter mapping has been rapidly developed from a lot of fundamental researches to the studies of clinical applications. At present, the dopaminergic neurotransmitter and receptor imaging in the central neurotransmitter mapping study are the most active area including dopaminergic receptor, dopaminergic neurotransmitter and dopaminergic transporter imaging, etc,. The nuclear medicine functional imaging technique with positron emission tomography and single photon emission computed tomography possesses potential advantages in the diagnosis and distinguished diagnosis of neuropsychiatric disorders and movement disorders, and in the study of recognition function.
2000, 24(2): 62-67.
Abstract:
123I-β-CIT (2β-carbomethoxy-3β-[4-iodophenyl]-tropane), a promising agent for imaging central dopamine transporter, has been successfully used in clinical and differential diagnosis and assessment of the magnitude of degeneration of nigrastriatum in Parkinson's disease.However, due to its poor selectivity for dopamine transporter and prolonged imaging intervel (usually 20h after injection), and therefore limits its clinical use. Several new imaging agents have been developed for dopamine transporter in recent years, and siginificantly improved the characterization for imaging dopamine transporter.
123I-β-CIT (2β-carbomethoxy-3β-[4-iodophenyl]-tropane), a promising agent for imaging central dopamine transporter, has been successfully used in clinical and differential diagnosis and assessment of the magnitude of degeneration of nigrastriatum in Parkinson's disease.However, due to its poor selectivity for dopamine transporter and prolonged imaging intervel (usually 20h after injection), and therefore limits its clinical use. Several new imaging agents have been developed for dopamine transporter in recent years, and siginificantly improved the characterization for imaging dopamine transporter.
2000, 24(2): 67-70.
Abstract:
123I-epidepride, 123I-(s)-N-[(1-ethyl-2-pyrrolidinyl) methyl]-5-iodo-2, 3-dimethoxybenzamide,is a potent imaging agent for SPECT of dopamine D2 receptor. With high affinity (Kd=24pmol/L) and relatively low lipophilicity (lgKw=2.05), it's suitable for imaging in striated and extrastriated. In addition, it has high value in imaging of dopamine D2 receptors in pituitary adenoma, and it can serve as a predictor for response to dopamine agonist treatment.
123I-epidepride, 123I-(s)-N-[(1-ethyl-2-pyrrolidinyl) methyl]-5-iodo-2, 3-dimethoxybenzamide,is a potent imaging agent for SPECT of dopamine D2 receptor. With high affinity (Kd=24pmol/L) and relatively low lipophilicity (lgKw=2.05), it's suitable for imaging in striated and extrastriated. In addition, it has high value in imaging of dopamine D2 receptors in pituitary adenoma, and it can serve as a predictor for response to dopamine agonist treatment.
2000, 24(2): 75-78.
Abstract:
The deep research of relation of apoptosis with radiotherapy makes it necessary to be clear about the relationship between apoptosis and radiosensitivity,so that this will provide a new standard of forecast and evaluation for clinical radiotherapy.These days study indicates that apoptosis and radiosensitivity have a subtle and complex relationship.This article reviews as follows regarding the relation of apoptosis rate ,cell cycle position and radiation dose rate with radiosensitivity.
The deep research of relation of apoptosis with radiotherapy makes it necessary to be clear about the relationship between apoptosis and radiosensitivity,so that this will provide a new standard of forecast and evaluation for clinical radiotherapy.These days study indicates that apoptosis and radiosensitivity have a subtle and complex relationship.This article reviews as follows regarding the relation of apoptosis rate ,cell cycle position and radiation dose rate with radiosensitivity.
2000, 24(2): 78-82.
Abstract:
Radiosensitivity is a complex phenomenon in tumor cells and there exist special biological effects in different types of tissues' cells in inadiation-induced cell responses. Tumor radiosentivity is tightly connected with irradiation-induced apoptosis and is regulated by many protein products of apoptosis-related genes such as p53 and related proteins, Bcl-2 gene family proteins, Fas and sphingomyelin/ceramide-mediated signalling pathways and caspases cascade etc.
Radiosensitivity is a complex phenomenon in tumor cells and there exist special biological effects in different types of tissues' cells in inadiation-induced cell responses. Tumor radiosentivity is tightly connected with irradiation-induced apoptosis and is regulated by many protein products of apoptosis-related genes such as p53 and related proteins, Bcl-2 gene family proteins, Fas and sphingomyelin/ceramide-mediated signalling pathways and caspases cascade etc.
2000, 24(2): 82-85.
Abstract:
An outline of current status on the influence of radiation on the development brain was given in the paper. Some genes as immediate early gene, Bcl-2 family, p53, heat shock protein and AT gene play an important regulation role in ionizing radiation-induced development brain cells apoptosis. And such biological factor as nerve growth factor, interlukin-l, tumor necrosis factor, basic fibroblast growth factor, transforming growth factor and so on have a vital protection function against ionizing radiation-induced cells apoptosis.
An outline of current status on the influence of radiation on the development brain was given in the paper. Some genes as immediate early gene, Bcl-2 family, p53, heat shock protein and AT gene play an important regulation role in ionizing radiation-induced development brain cells apoptosis. And such biological factor as nerve growth factor, interlukin-l, tumor necrosis factor, basic fibroblast growth factor, transforming growth factor and so on have a vital protection function against ionizing radiation-induced cells apoptosis.
2000, 24(2): 85-89.
Abstract:
Ceramide as an important member of sphingolipid is a second messenger responsible for regulating cellular activities, whose major function is to transmit growth-inhibiting signals including apoptotic.It has been proven by a lot of experimental facts that the changes of the functions at different levels of ceramide signaling pathway directly affect cellular drug sensitivity and radiation sensitivity.In addition, the defective functions of ceramide signaling path in tumor cells may result in the decrease of their drug sensitivity and radiation sensitivity.
Ceramide as an important member of sphingolipid is a second messenger responsible for regulating cellular activities, whose major function is to transmit growth-inhibiting signals including apoptotic.It has been proven by a lot of experimental facts that the changes of the functions at different levels of ceramide signaling pathway directly affect cellular drug sensitivity and radiation sensitivity.In addition, the defective functions of ceramide signaling path in tumor cells may result in the decrease of their drug sensitivity and radiation sensitivity.
2000, 24(2): 89-92.
Abstract:
The prevention of restenosis by radiation exists a lot of mecranisms, including smooth muscle cells (SMCs) division cycles arrests, inhibition of SMCs proliferation, SMCs apoptosis,inhibition of macrophage/monocyte and cytokines. Apoptosis is a major style of cell death induced by endovascular radiation. The inhibition of SMCs proliferation induced by radiation is a main mechanism for prevention of restenosis.
The prevention of restenosis by radiation exists a lot of mecranisms, including smooth muscle cells (SMCs) division cycles arrests, inhibition of SMCs proliferation, SMCs apoptosis,inhibition of macrophage/monocyte and cytokines. Apoptosis is a major style of cell death induced by endovascular radiation. The inhibition of SMCs proliferation induced by radiation is a main mechanism for prevention of restenosis.
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