Abstract: Pulmonary interstitial fibrosis(PIF) is a diffuse lung disease caused by different etiologies and affect interstitial tissue, alveoli and bronchiioles.PIF has the similar pathological process.Because of its diverse etiology, the complexity of the pathogenesis, treatment of difficult, PIF has became the research hotspot.Recently, PET/CT is widely used in tumor, cardiovascular disease and nervous disease, and has special advantages in earlydiagnosis, active estimate, efficacy monitoring and prognostic evaluation.This paper reviewed existing circumstances research of PET/CT in PIF at home and abroad.