原发性高血压PRA、AngⅡ分型和IGF-1水平的测定

Application of determination of PRA, Ang Ⅱ and IGF-1 levels in the study of typing of essential hypertension

    摘要
  • 摘要:
    目的 研究原发性高血压（EH）血浆肾素活性（PRA）、血管紧张素Ⅱ(AngⅡ)分型和胰岛素样生长因子1(IGF-1)水平测定的临床意义。
    方法 用放射免疫法分析256例EH患者和70名正常对照者PRA和AngⅡ水平，酶免疫法分析IGF-1水平，并进行EH分型和组间对比的研究。
    结果 正常对照组PRA为（0.432±0.236）μg·L-1·h-1，AngⅡ为（31.7±7.4）μg/L。256例EH患者按PRA水平分型：增高者占18.0%，正常者占71.8%和降低者占10.2%；按AngⅡ水平分型：增高者占12.9%，正常者占76.2%和降低者占10.9%；血浆IGF-1水平随E H患者的血压水平升高而增高。
    结论 EH按PRA和AngⅡ水平分型以及对EH患者进行IGF-1水平的测定，有助于EH患者的治疗和随访。

     

    Abstract:
    Objective To study the clinical application of determination of plasma renin activity(PRA), Angiotensin Ⅱ (Ang Ⅱ)and insulin-like growth factor-1(IGF-1)levels in typing of essential hypertension(EH).
    Methods Determined the levels of PRA and Ang Ⅱ in 256 patients with EH and 70 healthy volunteers(as control group)by radioimmunoassay, and measured IGF-1 level by enzyme immunoassay.Research on the typing of EH and the difference between the groups.
    Results The PRA and Ang Ⅱ in control group was(0.432±0.236)μg·L-1·h-1 and (31.7±7.4)μg/L respectively.In 256 patients with EH,PRA was increased, normal and decreased in 18.0%, 71.8% and 10.2% respectively, while the level of Ang Ⅱ was increased, normal and decreased in 12.9%, 76.2% and 10.9% respectively.The IGF-1 levels in 256 patients with EH were increased following the increase of blood pressure.
    Conclusion Typing of EH patients with PRA and Ang Ⅱ as well as the determination of IGF-1 were useful in treating and following up the patients with EH.

     

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