Objective To use Tracerlab FXC transformation to achieve a stable automated synthesis of ¹¹C-acetate, while performing necessary quality control and analysis of key factors of production yield.

Methods The devices that do not participate were short-circuited in the reaction of synthesis, adding external controllable valves or devices to control the external factors which may affect the synthesis yield.The active ¹¹C-CO₂ reacts with 500 μl of 0.5 mol/L methyl magnesium bromide and then quenched and diluted, and solid phase extraction was used to obtain ¹¹C-acetate.Quality control is applied to the final product according to Chinese Pharmacopoeia Fourth General.

Results The analysis of the key factors of yield was carried out to identify the major factors exerts the most considerable effect on the processing synthesis of ¹¹C-acetate.All results qualified after testing according to Chinese Pharmacopoeia quality control guidelines with five times of consecutive synthesis.

Conclusions Numerous factors affect the synthesis of ¹¹C-acetate, and production yield is highly unstable, as well.The modified Tracerlab FXC is able to produce ¹¹C-acetate in a faster, more stable, and secure approach, and the final product is also qualified according to the product standard.