Abstract: Nuclear medicine imaging modalities,including ¹⁸F-FDG,⁹⁹Tc^m-MIBI,²⁰¹Tl,radionuclide labeled antibody and other radioagent,had got certain value in detecting multiple myeloma.These methods were useful com plement of planar X photo,CT and MRI.Radionuclide scintigraphy can demonstrate the condition of whole body bone,stage of the disease and follow up the therapy result,but it needs other examinations to increase its diagnosis accuracy.