Abstract: The clinical transplantation of hematopoietic stem cell(HSC) originating from many sources such as bone marrow, peripheral blood and cord blood has been widely applied in recent years. At the same time, the development of the study on the mechanism of HSC homing which involves multi-procedures has been achieved. And a lot of molecular and cytokines on the surface or in the microenviroment of HSC are functioning in homing. The purpose of this article is to review those molecular and cytokines on which more studies have been focused in the past