Abstract:
Objective To investigate a fine experiment condition of indirect labeling method that Hepama-1-SPIONs(supeiparamagnetic iron oxide nanoparticles)was labelled with rhenium-188 complex(
188Re(CO)
3(H
2O)
3+).
Methods The Hepama-1-SPIONs bridged by bifunctional chelating agent 2-picolylamine-N,N-diacetic acid(PADA) was labelled rhenium-188-tricarbonyl complex prepared with high labeling yields.
Results The labeling rate of
188Re(CO)
3(H
2O)
3+-PADA-Hepama-1-SPIONs was more than 80%, and was extremely stable in vitro, The labeling rate of
188Re-(CO)
3(H
2O)
3-PADA-Hepama-1-SPIONs was more than 90% after 48 in calf serum and isotonic Na chloride.
Conclusions 188Re-(CO)
3(H
2O)
3-PADA-Hepama-1-SPIONs shows it's fine stability and biological properties, and it is well worth further researching as bio-magnetically targeted radiotherapy for cancer.
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