Abstract: The way about oncotherapy include radio therapy and gene therapy,in the recent years there are some improve about the therapy alliance, by the mechanism of improving the efficiency of the gene transfering, the recombination and conform of the DNA and induction the expressiong of the gene et. The radiotherapy can enhance the effect of the gene therapy. By the mechanism of improving of radiosensitivitysome, reducing the radiation damage of radiotherapy, repairing the radiation impaired gene the gene therapy can enhance the effect of the radiotherapy.