Abstract: WR-2721 (amifostine)is a broad-spectrum cytoprotector. Its active metabolite-WR1065 can protect normal cell, reduce the toxicities of radiotherapy and chemotherapy and improve hematoiogic cell. As a result, the patients may tolerate the high dose of chemo-radiotherapy. WR-2721 may be a new way on the therapies of the high-advanced and the multidrug resistant tumor.