Abstract: Sentinel lymph nodes (SLN)are regional lymph nodes first involved in metastatasis if lymphatic spread occurs.The SLN of solid tumor can be accurately identified by preoperative lymphoscintigraphy.Biopsy of the SLN is a highly precise,minimally invasive method of staging patients.The procedure may lead to a more justifiable approach to adjuvant therapy strategies with low complication.The SLN was identified in 80%~100% patients by lymphoscintigraphy. ⁹⁹Tc^m-sulfur colloid,⁹⁹Tc^m-colloidal albumin and ⁹⁹Tc^m-dextran has been the radiotracer for SLN mapping.Lymphoscintigraphy is a simple procedure that is well tolerated by patients.Until now,lymphoscintigraphy has been shown to effective for preop-erative lymphatic mapping and SLN localization in melanoma,breast cancer,and in other malignancies such as vulvar cancer.