Abstract: Pancreatic cancer is a comman disease that is seldom cured.Coventional therapy remaining dismal,immuno-radiotherapy may provide an immproved alternative for the treatment of pancreatic cancer.Because monoclonal antibody has a high specificity,radionuclide can retain enough high concentrations in tumor areas to kill tumor cells.But intact monoclonal antibody,due to their large size,shows poor defusion from the vasculature into and through the tumor,and it always induces a human anti-mouce.Geneticengineering antibody has led to a significant amount of research in radioim-munotherapy.It is essential to make improved progress for the treatment of pancreatic cancer.