Abstract: Epilepsy is a common disease and temporal lope epilepsy is the most common. It has a key role for the accurate presurgical lateralization and localization of epileptogenic cortical areas in the success of cortical resection for intractable epilepsy. Magnetic resonance imaging (MRI)is a significantly useful tool for the diagnosis of part of epilepsy, especially combined with electroen-cephalograph (EEG)and functional magnetic resonance imaging (fMRI). As for the negative patients with intractable epilepsy diagnosed by MRI, positron emission tomography (PET)can assist lateralization and localization of epileptogenic focus.