<sup>131</sup>I治疗Graves病伴白细胞减少的临床研究

¹³¹I治疗Graves病伴白细胞减少的临床研究

摘要: 目的探讨¹³¹I治疗Graves病(GD)伴外周血自细胞减少的疗效。方法对GD伴外周血白细胞减少患者¹³¹I治疗前后测定白细胞计数和甲状腺激素(三碘甲腺原氨酸、甲状腺素、促甲状腺激素)水平,并进行比较。结果 ¹³¹I治疗GD伴白细胞减少疗效显著,甲亢治愈率100%;¹³¹I治疗GD前后外周血白细胞计数没有明显变化,治疗后3个月血清甲状腺激素水平明显下降。结论 ¹³¹I治疗GD伴白细胞减少可行且疗效显著,治疗剂量的¹³¹I辐射对外周血白细胞水平没有影响。

Abstract: Objective To investigate the effect of ¹³¹I therapy Graves disease (GD) complicated with pefipheral blood leukopenia in hyperthyroid patients.Methods Serum T₃,T₄,TSH levels and peripheral blood white blood cell counts were determined in 16 GD complicated with leukopenia patients both before and after ¹³¹I therapy.Results ¹³¹I treatment of GD complicated with leukopenia patients was very successful (P<0.01),the cured rate was 100%.The peripheral blood white blood cell counts were few changes in GD patients both before and after ¹³¹I T₃,T₄,TSH levels was decreased within three months after ¹³¹I therapy.Conclusion The application of ¹³¹I to treat GD complicated with leukopenia was very successful.The therapeutic dose of ¹³¹I was no remarkable effect on peripheral blood white blood cell.