Abstract: Thyroid eye disease often associated with organ-specific autoimmune. Relationship has been found between a variety of serum cytokine level and clinical expression as well as the response to the treatment of patients with thyroid eye disease. The research of peripheral cytokine level in thyroid eye disease patients, including interleukin-1β, interleukin-2, interleukin-6, interleukin-8, tumor necrosis factor-α, insulin-like growth factor-1 is important.