低剂量辐射与糖尿病

赵红光; 蔡露; 龚守良

低剂量辐射与糖尿病

赵红光 , 蔡露 , 龚守良

文章导航 > 国际放射医学核医学杂志 > 2006, 30 > 1: (59-62)

引用本文:

Citation:

低剂量辐射与糖尿病

1. 130021 长春,吉林大学公共卫生学院卫生部放射生物学重点实验室;
2. 美国, 路易斯维尔KY 40202, 美国路易斯维尔大学
基金项目:
国家自然科学基金资助项目(39870312)
中图分类号: Q691.3;R587.1

Low dose radiation and diabetes mellitus

1. Ministry of Health, Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China;
2. Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, Louisville, KY 40202, USA
CLC number: Q691.3;R587.1

摘要: 低剂量辐射(LDR)诱导免疫兴奋效应及适应性反应的机制可能与LDR诱导的保护性蛋白和抗氧化物质有关,并在糖尿病(DM)及其他疾病中具有明显的治疗效果。主要综述LDR对DM发生发展及其并发症的作用和可能的机制,并讨论LDR应用于临床及DM并发症的前景。
- 剂量效应关系,辐射 /
- 糖尿病 /
- 兴奋效应 /
- 适应性反应
Abstract: Induction of hormesis and adaptive response by low-dose radiatio (LDR) has been extensively indicated. It's mechanism may be related with the protective protein and antioxidants that LDR induced, which take effects on the diabetes mellitus (DM) and other diseases. This review will summarize available data with emphasis on three points:the preventive effect of LDR on the development of diabetes, the therapeutic effect of LDR on diabetic complications and possible mechanisms by which LDR prevents the development of diabetes and diabetic complications. Finally, the perspectives of LDR clinical, diabetes-related implication are discussed.
- Dose-response relationship,radiation /
- Diabetes mellitus /
- Hormesis /
- Adaptive response
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Calabrese EJ.Hormesis:changing view of the dose-response,a personal account of the history and current status.Mutat Res,2002,511(3):181-189.
[2]	Calabrese EJ,Baldwin LA.Hormesis:the dose-response revolution.Annu Rev Pharmacol Toxicol,2003,43:175-197.
[3]	Calabrese EJ.Hormesis:a revolution in toxicology,risk assessment and medicine.EMBO Rep.2004:S37-S40.
[4]	Cai L,Kang YJ.Oxidative stress and diabetic cardiomyopathy:a brief review.Cardiovasc Toxicol,2001,1(3):181-193.
[5]	Takehara Y,Yamaoka K,Hiraki Y,et al.Protection against alloxan diabetes by low-dose ⁶⁰Co gamma irradiation before alloxan administration.Physiol Chem Phys Med NMR,1995,27(3):149-159.
[6]	Takahashi M,Kojima S,Yamaoka K,et al.Prevention of type Ⅰ diabetes by low-dose gamma irradiation in NOD mice.Radiat Res,2000,154(6):680-685.
[7]	Nakayama M,Nagata M,Yasuda H,et al.Fas/Fas ligand interactions play an essential role in the initiation of murine autoimmune diabetes.Diabetes,2002,51(5):1391-1397.
[8]	Sakai K,Normura T,Ina Y.Enhancement of bio-protective functions by low-dose/dose-rate radiation.Abstracts of the 14^th Pacific Basin Nuclear Conference,Honolulu:Hawaii,2004.364-367.
[9]	Reddy GK.Comparison of the photostimulatory effects of visible HeNe and infrared Ga-As lasers on healing impaired diabetic rat wounds.Lasers Surg Med,2003,33(5):344-351.
[10]	Byrnes KR,Barna L,Chenault VM,et al.Photobiomodulation improves cutaneous wound healing in an animal model of type Ⅱ diabetes.Photomed Laser Surg,2004,22(4):281-290.
[11]	Kawalec JS,Hetherington V J,Pfennigwerth TC,et al.Effect of a diode laser on wound healing by using diabetic and nondiabetic mice.J Foot Ankle Surg,2004,43(4):214-220.
[12]	Zinman LH,Ngo M,Ng ET,et al.Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy:a controlled trial.Diabetes Care,2004,27(4):921-924.
[13]	Chebotar'ova LL,Chebotar'ov HIe.Use of low-power electromagnetic therapy in diabetic polyneuropathy.Fiziol Zh,2003,49(2):85-90.
[14]	Hotta M,Tashiro F,Ikegami H,et al.Pancreatic beta cell-specific expression of thioredoxin,an antioxidative and antiapoptotic protein,prevents autoimmune and streptozotocin-induced diabetes.J Exp Med,1998,188(8):1445-1451.
[15]	Yamaoka K,Kataoka T,Nomura T,et al.Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice.J Radiat Res (Tokyo),2004,45(1):89-95.
[16]	Zhang H,Zheng RL,Wei ZQ,et al.Effects of pre-exposure of mouse testis with low-dose ⁽¹⁶⁾O⁸⁺ ions or ⁶⁰Co gamma-rays on sperm shape abnormalities,lipid peroxidation and superoxide dismutase (SOD)activity induced by subsequent high-dose irradiation.Int J Radiat Biol,1998,73(2):163-167.
[17]	Yamaoka K,Mitsunobu F,Hanamoto K,et al.Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy.J Radiat Res (Tokyo),2004,45(1):83-88.
[18]	Chilton PM,Rezzoug F,Fugier-Vivier I,et al.Flt3-ligand treatment prevents diabetes in NOD mice.Diabetes,2004,53(8):1995-2002.
[19]	Nikolic B,Takeuchi Y,Leykin I,et al.Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity.Diabetes,2004,53(2):376-383.
[20]	LiW,Wang G,CuiJ,et al.Low-dose radiation (LDR) induces hematopoietic hormesis:LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation.Exp Hematol,2004,32(11):1088-1096.
[21]	Ina Y,Sakai K.Prolongation of life span associated with immunological modification by chronic low-dose-rate irradiation in MRLlpr/lpr mice.Radiat Res,2004,161(2):168-173.
[22]	Kao MJ,Sheen LY.Effects of infrared and low-power laser irradiation on cell viability,glutathione and glutathione-related enzyme activities in primary rat hepatocytes.J Formosan Med Assoc,2003,102(7):486-491.
[23]	Schindl A,Heinze G,Schindl M,et al.Systemic effects of low-intensity laser irradiation on skin microcirculation in patients with diabetic microangiopathy.Microvasc Res,2002,64(2):240-246.

[1]	苏燎原 . 第二届《低和很低剂量电离辐射对人体健康效应》国际学术交流会议简介. 国际放射医学核医学杂志, 2001, 25(6): 265-271.
[2]	吕兑财 . 低剂量辐射兴奋效应及其机制. 国际放射医学核医学杂志, 2000, 24(6): 275-281.
[3]	高刚 . 低剂量辐射诱导适应性反应的分子机制研究现状. 国际放射医学核医学杂志, 2003, 27(6): 276-278.
[4]	吴国清 . 低剂量福射的细胞遗传适应性反应机理研究现状. 国际放射医学核医学杂志, 2002, 26(3): 127-130.
[5]	刘树铮 . 低水平辐射兴奋效应研究进展. 国际放射医学核医学杂志, 1996, 20(5): 219-223.
[6]	周平坤 , 夏寿萱 . 真核基因损伤修复和基因表达的辐射兴奋效应. 国际放射医学核医学杂志, 1996, 20(5): 223-226.
[7]	赵欣然 , 姜恩海 , 李进 , 刘强 , 邢志伟 , 江波 , 王晓光 , 姜立平 . 低剂量辐射兴奋效应的研究及临床应用. 国际放射医学核医学杂志, 2008, 32(2): 114-117.
[8]	李秀娟 , 李修义 . 低水平辐射兴奋效应与肿瘤. 国际放射医学核医学杂志, 1999, 23(2): 89-91.
[9]	孙志增 , 周平坤 . 低剂量电离辐射效应. 国际放射医学核医学杂志, 2004, 28(2): 82-85.
[10]	鞠桂芝 . 辐射细胞效应. 国际放射医学核医学杂志, 1996, 20(1): 29-32.