Abstract: Radiation-induced lung injury is a well-described complication of nuclear accidents, marrow-transplanted pretreatment, thoracic radiotherapy. Corticosteroid has been routinely employed to reduce the irradiation-induced lung injure, but has been demonstrated only marginal efficacy. Many researchers are addicted to research in this field, several preventions and treatments have been evaluated for their ability to reduce radiation-induced lung injury in animals and humans. Clarifying the research status and assisting the clinic at a certain extent are the aim of this article.