18F-氟脱氧葡萄糖PET-CT与99nTc-亚甲基二膦酸盐骨显像诊断转移性骨肿瘤的对比研究

Comparison study of 18F-fluorodeoxyglucose PET-CT and 99Tc-methylene phospho-nate bone scan in detecting bone metastases

    摘要
  • 摘要: 目的 探讨18F-氟脱氧葡萄糖(18F-FDG) PET-CT与唧99mTc-亚甲基二膦酸盐(99mTc-MDP)全身骨显像对转移性骨肿瘤的诊断价值。方法 93例经病理证实为恶性肿瘤的患者同时接受18F-FDG PET-CT和99mTc-MDP全身骨显像(时间间隔在1周之内),对比分析两种显像结果,骨转移的诊断通过随访2年,由病理、X射线片、CT或MRI检查结果综合决定。结果 93例恶性肿瘤患者中,经过2年随访或病理证实骨转移44例,其中18F-FDG PET-CT灵敏度、特异度和准确率分别为95.4%、91.8%和93.5%,99mTc-MDP全身骨显像分别为90.9%、63.3%和76.3%。18F-FDG PET-CT对转移性骨肿瘤诊断的灵敏度与99mTc-MDP全身骨显像相近,但特异度(t=2.53,P<0.05)和准确率t=2.47,P<0.05)均明显高于99mTc-MDP全身骨显像。结论 PET-CT对转移性骨肿瘤有较高的诊断价值。

     

    Abstract: Objective To investigate the diagnostic value of 18F-fluorodcoxyglucose PET-CT and 99mTc-methylene phosphonate whole body imaging in detection bone metastases.Methods 18F-FDG PET-CT and 99mTc-MDP whole body bone scan were both performed in 93 patients with malignant tumors testified by pathology.Bone metastases were confirmed by pathology,X ray or CT or MRI and follow-up for not less than 2 years.Results Of the 93 patients 44 were confirmed to have bone metastases by 2 years follow-up or pathology.The sensitivity,specificity and accuracy of 18F-FDG PET-CT were 95.4%,91.8%,93.5%,and 99mTc-MDP bone imaging were 90.9%,63.3%,76.3%,respectively.18F-FDG PET-CT has a better specificity (t=2.53,P<0.05)and accuracy (t=2.47,P<0.05)in detecting bone metastases than that of 99mTc-MDP bone imaging.Conclusion PET-CT is a more valuable method in the diagnosis of bone metastases.

     

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