Abstract: Objective To evaluate the clinical application value of nuclide bone imaging in malignant lymphoma. Methods 71 cases of patients were diagnosed by pathology as malignant lymphoma, among whom there were 8 cases of Hodgkin disease(HL) and 63 cases of non-Hodgkin disease (NHL). The examinations were performed from 2.5 to 6 hours later after the intravenous injection of ^99mTc-MDP (555-925MBq). Results 31 cases were bone-infiltrating lesions, including 3 cases of HL and 28 cases of NHL The total number of the focus was 103, except 2 cases of bone lack, including 35 foci in vertebral column (34.65%), 30 foci in limb and joint (29.70%), 14 foci in rib (13.86%), 13 foci in elvis (12.9%), 5 foci in skull (4.95%) and 4 foci in sternum (3.96%). Conclusion The nuclide bone imaging has a high value in the clinical stage, therapeutic observation and prognosis of bone-infiltrating malignant lymphoma.