恶性骨肿瘤多药耐药的99Tcm-MIBI体层显像研究
Research of 99Tcm-MIBI SPECT imaging for assessment of multidrug resistance in Bone tumor
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摘要: 大多数肿瘤都有多药耐药-1(MDR-1)基因的过度表达,其表达产物P-糖蛋白(P-gp)在肿瘤的耐药机制中起着关键作用,对P-gp表达的预测在化疗中至关重要,99Tcm-甲氧基异丁基异腈(99Tcm-MIBI)转运分析可作为探测低水平的P-gp表达和定量评价调节转运的敏感指标,指导应用调节剂改善化疗效果。Abstract: There has a overexpression ofmultidrug resistance (MDR) gene in most tumor. It is very important that it's expression product P-glycoprotein(P-gp)in multidrug resistance machine of tumor. The anticipation for P-gp expression is significance for chemotherapy. The conveying analysis of 99Tcm-sestamibi (99Tcm-MIBI) is a sensitiveness index for low-level P-gp expression.
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