Abstract: Mostly radionuclide therapy was used as a sole method in clinical practice and seldom combined with chemotherapy, immunotherapy or radiotherapy as a treatment procotol. Pain palliation of bone metastases has become a main field in radionuclide therapy in the recent years and strontium-89 is a main radionuclide clinically used. Combining with chemotherapy, doxorubicin, gemcitabin, cisplatin, and radiotherapy can enhance the affect of radionuclide therapy and prolong the period of pain palliation. This con-comitant method was used in the treatment of lymphoma, neuroblastoma and glioma and showed excellent prospect.