Abstract: ¹⁸F-FDG PET has been widely studied and applied in the diagnosis and therapeutic evaluation in oncology. Although relatively fewer reports about ¹⁸F-FDG PET in skeletal and soft tissue tumors have been seen, in recent years a lot of studies have been published which covered over malignancy discrimination, grading, therapeutic monitoring and evaluation, and metastasis detection of skeletal and soft tissue tumors with ¹⁸F-FDG PET.