Abstract: In recent years, the research of tumor nuclide internal radiation treatment has been carried out encouraging result. ⁹⁰Y has been regarded green non-environmental damage nuclide. Intrahepatic arterial injection of ⁹⁰Y-glass microspheres perform dual function at embolism tumor blood supply artery and the internal radiation treatment tumor. It has many merits include simplified operation, wide-ranging indication, side effect few and the tumor response obvious. And the patient's survival rate and position lifetime has been effective enhanced. Along with the further development of microspheres material technique, this method will entirely possible to achieve a new effective and safe therapy for the patient and has extensively clinical foreground.