Abstract: Pheochromocytomas and paragangliomas can synthesise and secrete catecholamines, causing a variety of clinical symptoms, such as hypertensive crisis.The diagnosis and management of pheochromocytomas and paragangliomas largely depend on the qualitation and location of the tumor.With the development of molecular imaging and nuclear medicine, they make the diagnosis of pheochromocytomas and paragangliomas more sensitive and accurate, and provide a new treatment for patients with malignant pheochromocytomas especially that with metastasis.The article focuses on the radionuclide in the diagnosis of pheochromocytomas, paragangliomas and familial pheochromocytomas, and the management of malignant pheochromocytomas.