Abstract: Astrocyte is the most glial cell in the central nervous system.In the present experi-ment, radiation injury to the central nervous system(CNS)triggers a large network of cellular changes including neuron, glialcell and endothelial cell in morphology and metabolism and function.Astrocyte changes rapidly after ionizing radiation.There is a ralationship between astrocyte and the pathologic process and function recover of damaged brain tissue following CNS injury.This suggests that astrocyte plays an important role in cure of clinical radiation injury.