Abstract: Thyroid cancer is one of the most common endocrinal carcinomas, and the differentiated thyroid carcinoma (DTC) is about 80 percent of it. The up-to-date scheme of DTC therapy is surgery+radioiodine therapy+thyroxine inhibition, it effectively reduce the risk of recurrence of DTC. Radioiodine therapy of DTC include two aspects, one is the ablation of thyroid remnant and the other is the therapy of metastasis. The methods to increase the radioiodine uptake in lesions of DTC are reviewed in this article. Studys suggest these methods could increase the uptake of radioiodine in lesions of DTC obviously.