99mTc-HL91显像在缺血陛脑血管病中脑乏氧组织的应用研究
Preliminary study on detection of brain hypoxic tissue in the patients with ischemic cerebrovascular of brain using 99mTc-HLgl imaging
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摘要: 目的 探讨99mTc-4,9-二氮。3,3,10,10-四甲基十二烷-2,11-二酮肟(99mTc-HL91)在缺血性脑血管病中脑乏氧组织的临床应用价值。方法 对9例对照组和17例急性脑梗死患者于起病7 d内进行脑乏氧显像,同时进行了CT或MRI检查。其中2例分别于第一次显像阳性后9 d和12 d进行第二次乏氧显像。结果 对照组未见脑实质有明显核素浓聚,左侧,右侧比值为0.98±0.04.17例急性脑梗死患者中,乏氧显像阳性11例,阳性率64.7%,其患侧/健侧比值为1.54±0.55,与对照组比较有显著性差异(t=3.081,P<0.05)。结论 99mTc-HL91显像可以区分乏氧与坏死的脑组织,对指导治疗、评价疗效有一定的临床意义。Abstract: Objective To investigate the detection of brain hypoxic tissue in patients with ischemic cerebrovaseular of brain using 99mTc-4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime(99mTc-HL91)maging.Methods Nine controls and 17 patients with acute infarction of brain underwent 99mTc-HL91 imaging.Results The ratios of left/fight in controls is 0.98±0.04.The ratios of L/N in patients is 1.54±0.55.Conclusion 99mTc-HL91 imaging could detect brain hypoxie tissue after ischemic cerebrovascular of brain.
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