Abstract: Whole-body bone scintigraphy using ⁹⁹Tc^m-methylene diphosphonate, one of the most commonly performed radionuclide examinations, is the first choice for early diagnosis of bone metastases.However, the artifact imaging of the extraosseous tissues invariably affects the accuracy of the diagnosis.It is important to consider all the possible factors of the extraosseous uptake of the imaging agent and aggregate analyse during interpreting the examination.The common causes including the radioactive drug, the injection, the patient-self and so on.