环氧合酶-2抑制剂及其辐射增敏效应
COX-2 inhibitors and enhancement of tumor radiosensitivity
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摘要: 环氧合酶-2(COX-2)抑制剂因其广泛的预防和抑制肿瘤作用,近年来得到人们的关注。COX-2抑制剂与射线合并作用于肿瘤细胞时产生了辐射增敏现象,增敏的机制可能是COX-2抑制剂改变了细胞周期分布,抑制细胞的亚致死性损伤修复,提高对辐射诱导凋亡易感性等。Abstract: Cyclooxygenase-2(COX-2) inhibitors has recently received extensive attention for its role in prevention and inhibition of malignancies. COX-2 inhibitors are enhancers of tumor cells response to irradiation. The possible mechanisms consist of effect on cell cycle distribution, inhibition of repair from sublethal radiation damage, increasing susceptibility of cells to radiation-induced apoptosis.