Abstract: The values of ⁹⁰Y-octreotide and ¹⁷⁷Lu-octreotate in tumor treatment were briefly reviewed.The rationale of clinincal applications, the distribution of radiopeptide in tumor and nomal tissues and appli-cation of renal protective agents were reviewed as well. Tumor with potential therapeutic responses are many such as non-iodide avid cancer of thyroid gland, Hurthle cell thyroid cancer, medullary thyroid cancer, neuroendo-gastro-entero-pancreatic(GEP)tumor, small cell l cancer, carcinoid tumors and pheochromocytoma. The current state of clinical use of radiopeptide for therapy of tumors, the development of new compounds and future development, the dosage of radiopeptide for tumor treatment with well tolerated and remarkable clinical benefit were presented.