Abstract: RNA interference (RNAi) is a post-transcriptional gene silencing induced by introduction of double-stranded RNA (dsRNA). The emerging of RNAi provided a new method for glioma gene therapy. During the research, many new potential genes are continually finding out. And the glioma-treating mechanism include inhibiting cell proliferation, inducing cell apoptosis, blocking cell eyele and enhancing cell sensitivity of chemical.