Abstract: The malignant tumors must establish a neovasculature to grow, to invade, and to metastasize, in which α_vβ₃ integrin plays an important role. It is reported that the α_vβ₃ integrin made their effection mainly by binding triplet peptides RGD sequence in the proteins of the extracellular matrix. Because is reported to there is no or rare α_vβ₃ integrin in normal cells but more in activated endothelial cells, RGD is the special target point for α_vβ₃ Integrin. RGD antagonistic peptides radiolabelled by direct or indirect way could be used to display tumor α_vβ₃ Integrin by nuclear medicine image. It is of significance to locate and quantitate tumor Integrin high special in early diagnosis and therapy. This article reviews the marking method of RGD peptide and study about the image of α_vβ₃ receptor.