Abstract: Tumor treatment is one of the most important fields in medical research.Nowadays, a novel method which is combined gene therapy with radiotherapy plays an important role in the field of cancer research,and mainly includes immune gene therapy combined with radiotherapy,suicide gene therapy or tumor suppressor gene therapy combined with radiotherapy,antiangiogenesis gene therapy combined with radiotherapy and protective gene therapy combined with radiotherapy based on the technical features.This review summarized the current status of combined therapies of gene therapy and radiotherapy and possible mechanism.