Abstract: VEGF (vascular endothelial growth factor)is important for tumor growth,local invasion and the distant metastasis.It provides important information about the biology and the clinical behavior of tumors undergoing radiotherapy.This review summarizing the present study reports and suggests: (1)Irradiation can induce VEGF expression in diverse tumor cell types. (2)VEGF can be as a predictive factor of response to radiotherapy.VEGF increases in tumors will be resistant to radiation therapy.Anti-VEGF strategies can be used in combination with radiation therapy,and it can increase the anti-tumor effects of radiation therapy.A classification of tumors according to their VEGF level before therapy can be used into designed individual treatment planning.