Abstract: The morbidity of diabetes mellitus and coronary artery disease(CAD)is gradually in-creasing. diabetes mellitus can improve the danger of atherosclerosis and cardiovascular disease, es-pecially CAD. Up to 75% of all deaths among diabetes can be directly attributed to CAD. SPECT myocar-dial perfusion imaging is valuable in early detecting latent myocardial ischemia, and effec-tively risk-stratifiying diabetic patients. The results of myocardial perfusion imaging can evaluate prognosis and curative effect, and provide important evidence for clinical therapeutic strategy.