Abstract: Myocardial hypoxia imagings provide noninvasive approaches for the detection of myocardial ischemia, dedication of the potential role of hypoxia in development of angiogenesis and cardiomyopathy by the detection of balance of flow and oxygen consumption. Animal experiments and clinical trials show fluoromisonidazole and technetium-99m labeled nitroimidazoles and novel class hypoxia imaging markers have been developed for imaging of regional myocardial ischemia. The true clinical applications rely on future experimental and clinical studies.