Abstract: Thyrotropin receptors antibodies may occur and induce Graves' disease (GD) several months after radioiodine therapy in a small number of patients with nontoxic goiter. The prevalence of radiation-induced GD is between 0.05% and 5%. The hypothesis of this disease includes induction by autoimmune reaction and others. Detection of the thyroid autoantibodise or of ^99mTc pertechnetate scan can forecast the appearance of GD. Anfithyroid drugs,again radioiodine therapy and surgery are the treatments.