Abstract: Objective To investegat the influence factors of bone scintigraphy in hepatic carcinoma and hepatocirrhosis patients and how to improve image quality. Methods The routine bone scintigraphy, furosemide interventional test and increase radioactivity test were performed on 90 hepatic carcinoma and hepatocirrhosis. Results Bone-to-soft tissue ratio of hepatic carcinoma group was increased 15% after furosemide interventional test. There was significant difference (t=2.39, P<0.05). Hepatocirrhosis without hepatic carcinoma and hepatic carcinoma followed hepatocirrhosis group were increased 16% and 20% (t=2.52, t=2.96, P<0.01). The B/ST ratio of three groups were increased 26%, 30%, 31% respectively after increase radioactivity test(t=3.08, t=3.36, t=3.39, P<0.01). Conclusion Influence factors of bone scintigraphy in hepatic carcinoma and hepatocirrhosis are renal function, ascites, chemotherapy, anaemia et al. We suggest that use mentioned methods in order to improve image quality.