Abstract: The risk for conversion to dementia is much higher in individuals with mild eoghitived impairmaent (MCI).The early detection of MCI individuals who will later convert to Alzheimer disease is an important issue for both clinical and research interests.Radionuclide imaging has been broadly used to study cerebral membolism and blood flow,as well as predicting the prognosis of MCI.This review summarizes the results of these studies assessing the predicting value of radionuelide imaging used alone and with other methods in recent years.