Abstract: ¹⁸FF-FDG imaging can provide information about the biologic characteristics of malignant cells,and has high target-to-nontarget ratios in most common neoplasms,recently has been successfully used in various neoplasms throughout the body.However ¹⁸F-FDG is a non specific tracer,and it has been found to accumulate at sites of normal tissue and some benign pathologic.This uptake of nonmalignant tissue may be misinterpreted as a false positive result or mask a nearby malignant lesion.We describe various nonmalignant uptake's characteristic and differential including physiologic,benign,infection and inflammation,image fusion,dual time point imaging be applied to distinguish nonmalignant accumulations.Con sider the combined imaging fusion is the first optimal modality in distinguish m alignant accumulations from physiologic.