Abstract: Objective To evaluate the therapeutic effects of stereotactic radiotherapy (SRT) on pancreatic cancer. Methods Sixteen patients were treated with SRT, tumor volume 26.5~116.5cm³, single tumor dosage ranged from 3Gy to 5Gy in 10 to 20 fractions, five fractions per week. Patients were followed clinically and image. Results The overall response rate (CR+PR) was 81.2%; the life quality has been improved in evidence. The median survival time was 11 months; the most reason of death was metastasis:The evaluation for acute and late complications related to the treatment was base on RTOG standard, 68.7% patients developed acute complications, and one patient had developed grievously later responses. Conclusion Stereotactic radiotherapy can be used effectively to local control in patients with pancreas cancer, improves life quality, and complications related to the treatment can be accepted by clinically, but tumor metastasis is significantly related with the survival time of patients, combined chemotherapy may be improve survival rate of the patients.